{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:36:43Z","timestamp":1792787803905,"version":"4.5.0"},"reference-count":40,"publisher":"European Respiratory Society (ERS)","issue":"2","funder":[{"name":"The Lung Association, Alberta & NWT","award":["1007883"],"award-info":[{"award-number":["1007883"]}]},{"DOI":"10.13039\/501100000082","name":"Cystic Fibrosis Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000082","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000146","name":"Alberta Innovates - Technology Futures","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000146","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["ERJ Open Res"],"accepted":{"date-parts":[[2018,4,13]]},"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:p>\n                    The natural history and epidemiology of\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    infections in non-cystic fibrosis (non-CF) bronchiectasis is not well understood.\n                  <\/jats:p>\n                  <jats:p>\n                    As such it was our intention to determine the evolution of airway infection and the transmission potential of\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    in patients with non-CF bronchiectasis.\n                  <\/jats:p>\n                  <jats:p>\n                    A longitudinal cohort study was conducted from 1986\u20132011 using a biobank of prospectively collected isolates from patients with non-CF bronchiectasis. Patients included were \u226518 years old and had \u22652 positive\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    cultures over a minimum 6-month period. All isolates obtained at first and most recent clinical encounters, as well as during exacerbations, that were morphologically distinct on MacConkey agar were genotyped by pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST). A total of 203 isolates from 39 patients were analysed. These were compared to a large collection of globally epidemic and local CF strains, as well as non-CF isolates.\n                  <\/jats:p>\n                  <jats:p>We identified four patterns of infection in non-CF bronchiectasis including: 1) persistence of a single strain (n=26; 67%); 2) strain displacement (n=8; 20%); 3) temporary disruption (n=3; 8%); and 4) chaotic airway infection (n=2; 5%). Patterns of infection were not significant predictors of rates of lung function decline or progression to end-stage disease and acquisition of new strains did not associate with the occurrence of exacerbations. Rarely, non-CF bronchiectasis strains with similar pulsotypes were observed in CF and non-CF controls, but no CF epidemic strains were observed. While rare shared strains were observed in non-CF bronchiectasis, whole-genome sequencing refuted patient\u2013patient transmission.<\/jats:p>\n                  <jats:p>We observed a higher incidence of strain-displacement in our patient cohort compared to those observed in CF studies, although this did not impact on outcomes.<\/jats:p>","DOI":"10.1183\/23120541.00162-2017","type":"journal-article","created":{"date-parts":[[2018,6,18]],"date-time":"2018-06-18T05:59:55Z","timestamp":1529301595000},"page":"00162-2017","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["Epidemiology and natural history of\n                    <i>Pseudomonas aeruginosa<\/i>\n                    airway infections in non-cystic fibrosis bronchiectasis"],"prefix":"10.1183","volume":"4","author":[{"given":"Taylor E.","family":"Woo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Surette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Waddell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel C.","family":"Bowron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjani","family":"Somayaji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Duong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher H.","family":"Mody","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harvey R.","family":"Rabin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas G.","family":"Storey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Parkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2018,6,18]]},"reference":[{"key":"2024101707085325000_4.2.00162-2017.1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.136119"},{"key":"2024101707085325000_4.2.00162-2017.2","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-015-0167-9"},{"key":"2024101707085325000_4.2.00162-2017.3","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00003709"},{"key":"2024101707085325000_4.2.00162-2017.4","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00074605"},{"key":"2024101707085325000_4.2.00162-2017.5","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.065664"},{"key":"2024101707085325000_4.2.00162-2017.6","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.060913"},{"key":"2024101707085325000_4.2.00162-2017.7","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200309-1306OC"},{"key":"2024101707085325000_4.2.00162-2017.8","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201409-1646OC"},{"key":"2024101707085325000_4.2.00162-2017.9","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.03218-13"},{"key":"2024101707085325000_4.2.00162-2017.10","doi-asserted-by":"publisher","DOI":"10.1007\/s004300050050"},{"key":"2024101707085325000_4.2.00162-2017.11","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-015-0856-5"},{"key":"2024101707085325000_4.2.00162-2017.12","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-015-0116-x"},{"key":"2024101707085325000_4.2.00162-2017.13","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00204411"},{"key":"2024101707085325000_4.2.00162-2017.14","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02108-2016"},{"key":"2024101707085325000_4.2.00162-2017.15","doi-asserted-by":"crossref","unstructured":"Mitchelmore PJ , Randall J , Bull MJ , et al. 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