{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T22:21:13Z","timestamp":1783722073991,"version":"3.55.0"},"reference-count":35,"publisher":"European Respiratory Society (ERS)","issue":"6","license":[{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-RS-2023-00273095"],"award-info":[{"award-number":["NRF-RS-2023-00273095"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018688","name":"Korea Disease Control and Prevention Agency","doi-asserted-by":"publisher","award":["2023040B4A0-01"],"award-info":[{"award-number":["2023040B4A0-01"]}],"id":[{"id":"10.13039\/100018688","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["ERJ Open Res"],"accepted":{"date-parts":[[2025,4,12]]},"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study investigated the effect of population ageing on the epidemiology of tuberculosis (TB) in South Korea.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cohort study using an integrated database from three national databases. We analysed trends in age-specific TB incidence, mortality, case fatality rates and risk factors for all-cause mortality among 328\u2009637 patients with drug-susceptible TB from 2011 to 2020.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From 2011 to 2020, the proportion of patients aged \u226565\u2005years increased from 30.5% to 50.7% of TB cases and from 74.3% to 86.8% of deaths. The TB incidence rate decreased from 90.3 to 39.5 per 100\u2009000 (average annual per cent change (AAPC) \u22128.5%; 95% confidence interval (CI) \u22129.2 to \u22127.7). The crude mortality rate remained largely unchanged, shifting from 4.6 to 5.4 per 100\u2009000 (AAPC 1.6%; 95% CI \u22120.1 to 3.1). The case fatality rate increased from 5.1% to 13.5% (AAPC 11.3%; 95% CI 10.5 to 12.1). Although incidence and mortality declined across all age groups, the rate of decline slowed with increasing age. Patients aged \u226580\u2005years showed the slowest decline in incidence (AAPC \u22124.3%; 95% CI \u22125.4 to \u22123.5) and stagnation in mortality (AAPC 0.5%; 95% CI \u22121.4 to 2.2).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study highlights the challenges of population ageing on TB control, including increasing case fatality rates and slower declines in TB incidence and mortality. These findings call for a reassessment of current strategies to address the needs of the elderly.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1183\/23120541.00191-2025","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T06:50:12Z","timestamp":1748415012000},"page":"00191-2025","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["The impact of population ageing on tuberculosis incidence, mortality, and case fatality in South Korea: a nationwide retrospective study"],"prefix":"10.1183","volume":"11","author":[{"given":"Seung Won","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8206-9487","authenticated-orcid":false,"given":"Doosoo","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8853-7061","authenticated-orcid":false,"given":"Hongjo","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5643-6095","authenticated-orcid":false,"given":"Chiwook","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeongha","family":"Mok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6260-0277","authenticated-orcid":false,"given":"Dawoon","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hojoon","family":"Sohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7783-5271","authenticated-orcid":false,"given":"Young Ae","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2025,5,28]]},"reference":[{"key":"2025111002401162000_11.6.00191-2025.1","unstructured":"World Health Organization . 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