{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:40:31Z","timestamp":1782348031296,"version":"3.54.5"},"reference-count":41,"publisher":"European Respiratory Society (ERS)","issue":"6","license":[{"start":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T00:00:00Z","timestamp":1724284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["ERJ Open Res"],"accepted":{"date-parts":[[2024,7,10]]},"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Bronchiectasis (BE) is a disease defined by irreversible dilatation of the airway. Computed tomography (CT) plays an important role in the detection and quantification of BE. The aim of this study was three-fold: 1) to assess bronchus\u2013artery (BA) dimensions using fully automated software in a cohort of BE disease patients; 2) to compare BA dimensions with semi-quantitative BEST-CT (Bronchiectasis Scoring Technique for CT) scores for BE and bronchial wall thickening; and 3) to explore the structure\u2013function relationship between BA-method lumen dimensions and spirometry outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Baseline CTs of BE patients who participated in a clinical trial were collected retrospectively. CTs were analysed manually with the BEST-CT scoring system and automatically using LungQ (v.2.1.0.1, Thirona, The Netherlands), which measures the following BA dimensions: diameters of bronchial outer wall (B<jats:sub>out<\/jats:sub>), bronchial inner wall (B<jats:sub>in<\/jats:sub>) and artery (A), and bronchial wall thickness (B<jats:sub>wt<\/jats:sub>) and computes BA ratios (B<jats:sub>out<\/jats:sub>\/A and B<jats:sub>in<\/jats:sub>\/A) to assess bronchial widening. To assess bronchial wall thickness, we used the B<jats:sub>wt<\/jats:sub>\/A ratio and the ratio between the bronchus wall area (B<jats:sub>wa<\/jats:sub>) and the area defined by the outer airway (B<jats:sub>oa<\/jats:sub>) (B<jats:sub>wa<\/jats:sub>\/B<jats:sub>oa<\/jats:sub>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 65 patients and 16\u2009900 BA pairs were analysed by the automated BA method. The median (range) percentage of BA pairs defined as widened was 69 (55\u201384)% per CT using a cut-off value of 1.5 for B<jats:sub>out<\/jats:sub>\/A, and 53 (42\u201365)% of bronchial wall were thickened using a cut-off value of 0.14 for B<jats:sub>wt<\/jats:sub>\/A. BA dimensions were correlated with comparable outcomes for the BEST-CT scoring method with a correlation coefficient varying between 0.21 to 0.51. The major CT BA determinants of airflow obstruction were bronchial wall thickness (p=0.001) and a narrower bronchial inner diameter (p=0.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The automated BA method, which is an accurate and sensitive tool, demonstrates a stronger correlation between visual and automated assessment and lung function when using a higher cut-off value to define bronchiectasis.<\/jats:p><\/jats:sec>","DOI":"10.1183\/23120541.00231-2024","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T16:44:03Z","timestamp":1724345043000},"page":"00231-2024","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Automated method of bronchus and artery dimension measurement in an adult bronchiectasis population"],"prefix":"10.1183","volume":"10","author":[{"given":"Angelina L.P.","family":"Pieters","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianting","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer J.","family":"Meerburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3085-603X","authenticated-orcid":false,"given":"Tjeerd","family":"van der Veer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni-Rosalina","family":"Andrinopoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4017-8957","authenticated-orcid":false,"given":"Pierluigi","family":"Ciet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D.","family":"Chalmers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Loebinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles S.","family":"Haworth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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