{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T04:10:10Z","timestamp":1769832610452,"version":"3.49.0"},"reference-count":33,"publisher":"European Respiratory Society (ERS)","issue":"3","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"The Vancouver Coastal Health Research Institute"},{"name":"The University of British Columbia\u2019s Strategic Investment Fund"},{"DOI":"10.13039\/501100000245","name":"Michael Smith Foundation for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000245","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The TB Vets charitable foundation"}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["ERJ Open Res"],"accepted":{"date-parts":[[2021,6,11]]},"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this study was to compare respiratory and patient-reported outcome measures (PROMs) between 3 and 6\u2005months after symptom onset and to identify features that predict these changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a consecutive prospective cohort of 73 patients who were hospitalised with coronavirus disease 2019 (COVID-19). We evaluated the changes in pulmonary function tests and PROMs between 3 and 6\u2005months and then investigated the associations between outcomes (change in diffusing capacity of the lung for carbon monoxide (<jats:italic>D<\/jats:italic><jats:sub>LCO<\/jats:sub>), dyspnoea and quality of life (QoL)) and clinical and radiological features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was improvement in forced vital capacity, total lung capacity and<jats:italic>D<\/jats:italic><jats:sub>LCO<\/jats:sub>between 3 and 6\u2005months by 3.25%, 3.82% and 5.69%, respectively; however, there was no difference in PROMs. Reticulation and total computed tomography (CT) scores were associated with lower<jats:italic>D<\/jats:italic><jats:sub>LCO<\/jats:sub>% predicted at 6\u2005months (coefficients; \u22128.7 and \u22125.3, respectively). The association between radiological scores and<jats:italic>D<\/jats:italic><jats:sub>LCO<\/jats:sub>were modified by time, with the degree of association between ground glass and<jats:italic>D<\/jats:italic><jats:sub>LCO<\/jats:sub>having decreased markedly over time. There was no association between other predictors and change in dyspnoea or QoL over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There is improvement in pulmonary function measurements between 3 and 6\u2005months after COVID-19 symptom onset; however, PROMs did not improve. A higher reticulation and total CT score are negatively associated with<jats:italic>D<\/jats:italic><jats:sub>LCO<\/jats:sub>, but this association is attenuated over time. Lastly, there is a considerable proportion of patients with unexplained dyspnoea at 6\u2005months, motivating further research to identify the underlying mechanisms.<\/jats:p><\/jats:sec>","DOI":"10.1183\/23120541.00243-2021","type":"journal-article","created":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T16:25:13Z","timestamp":1626971113000},"page":"00243-2021","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":21,"title":["Changes in pulmonary function and patient-reported outcomes during COVID-19 recovery: a longitudinal, prospective cohort study"],"prefix":"10.1183","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7260-8256","authenticated-orcid":false,"given":"Aditi S.","family":"Shah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3071-7363","authenticated-orcid":false,"given":"Min Hyung","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cameron J.","family":"Hague","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0266-7883","authenticated-orcid":false,"given":"Darra T.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8879-4989","authenticated-orcid":false,"given":"James C.","family":"Johnston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1049-393X","authenticated-orcid":false,"given":"Christopher J.","family":"Ryerson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2455-6575","authenticated-orcid":false,"given":"Christopher","family":"Carlsten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alyson W.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2021,7,22]]},"reference":[{"key":"2024101711143960000_7.3.00243-2021.1","unstructured":"World Health Organization. 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