{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T05:10:36Z","timestamp":1740460236342,"version":"3.37.3"},"reference-count":34,"publisher":"European Respiratory Society (ERS)","issue":"3","license":[{"start":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T00:00:00Z","timestamp":1675296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Spanish Ministry of Science, Innovation and Universities","award":["RTI2018- 098472-B-I00 MCIU\/AEI\/FEDER, UE."],"award-info":[{"award-number":["RTI2018- 098472-B-I00 MCIU\/AEI\/FEDER, UE."]}]},{"name":"Severo Ochoa programme of the Spanish Ministry of Science and Competitiveness","award":["SEV-2014-0425 (2015-2019)"],"award-info":[{"award-number":["SEV-2014-0425 (2015-2019)"]}]},{"name":"CERCA Program\/Generalitat de Catalunya & Secretaria d\u2019Universitats i Recerca de la Generalitat de Catalunya","award":["GRC 2017 SGR 01770"],"award-info":[{"award-number":["GRC 2017 SGR 01770"]}]},{"name":"European Commission under Horizon 2020s Marie-Sklodowska-Curie Actions COFUND scheme","award":["GA 712754"],"award-info":[{"award-number":["GA 712754"]}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["ERJ Open Res"],"accepted":{"date-parts":[[2023,1,7]]},"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Acute respiratory syndrome due to coronavirus 2 (SARS-CoV-2) is characterised by heterogeneous levels of disease severity. It is not necessarily apparent whether a patient will develop severe disease or not. This cross-sectional study explores whether acoustic properties of the cough sound of patients with coronavirus disease 2019 (COVID-19), the illness caused by SARS-CoV-2, correlate with their disease and pneumonia severity, with the aim of identifying patients with severe disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Voluntary cough sounds were recorded using a smartphone in 70 COVID-19 patients within the first 24\u2005h of their hospital arrival, between April 2020 and May 2021. Based on gas exchange abnormalities, patients were classified as mild, moderate or severe. Time- and frequency-based variables were obtained from each cough effort and analysed using a linear mixed-effects modelling approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Records from 62 patients (37% female) were eligible for inclusion in the analysis, with mild, moderate and severe groups consisting of 31, 14 and 17 patients respectively. Five of the parameters examined were found to be significantly different in the cough of patients at different disease levels of severity, with a further two parameters found to be affected differently by the disease severity in men and women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We suggest that all these differences reflect the progressive pathophysiological alterations occurring in the respiratory system of COVID-19 patients, and potentially would provide an easy and cost-effective way to initially stratify patients, identifying those with more severe disease, and thereby most effectively allocate healthcare resources.<\/jats:p><\/jats:sec>","DOI":"10.1183\/23120541.00247-2022","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T17:20:21Z","timestamp":1675358421000},"page":"00247-2022","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Differences in acoustic features of cough by pneumonia severity in patients with COVID-19: a cross-sectional study"],"prefix":"10.1183","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3420-1201","authenticated-orcid":false,"given":"Clare","family":"Davidson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5028-7439","authenticated-orcid":false,"given":"Oswaldo 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