{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:24:50Z","timestamp":1787505890536,"version":"build-2736575974"},"reference-count":36,"publisher":"European Respiratory Society (ERS)","issue":"3","license":[{"start":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T00:00:00Z","timestamp":1622073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Visare Norr"},{"name":"ALF-a regional agreement between Ume\u00e5 University and Norrbotten County Council"},{"DOI":"10.13039\/501100009772","name":"Norrbottens L\u00e4ns Landsting","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009772","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010234","name":"Astma- och Allergif\u00f6rbundet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010234","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["ERJ Open Res"],"accepted":{"date-parts":[[2021,5,27]]},"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The prevalence of asthma has increased both among children and adults during the latter half of the 20th century. The prevalence among adults is affected by the incidence of asthma not only in childhood but also in adulthood. Time trends in asthma incidence have been poorly studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The aim of this study was to review the incidence of adult-onset asthma from 1996 to 2006 and 2006 to 2016 and compare the risk factor patterns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In the Obstructive Lung Disease in Northern Sweden (OLIN) studies, two randomly selected population-based samples in the 20\u201369-year age group participated in postal questionnaire surveys about asthma in 1996 (n=7104, 85%) and 2006 (n=6165, 77%). A 10-year follow-up of the two cohorts with the same validated questionnaire was performed, and 5709 and 4552 responded, respectively. Different definitions of population at risk were used in the calculations of asthma incidence. The protocol followed a study performed between 1986 and 1996 in the same area.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The crude incidence rate of physician-diagnosed asthma was 4.4 per 1000 person-years (men 3.8, women 5.5) from 1996 to 2006, and 4.8 per 1000 person-years (men 3.7, women 6.2) from 2006 to 2016. When correcting for possible under-diagnosis at study entry, the incidence rate was 2.4 per 1000 person-years from 1996 to 2006 and 2.6 per 1000 person-years from 2006 to 2016. The incidence rates were similar across age groups. Allergic rhino-conjunctivitis was the main risk factor for incident asthma in both observation periods (risk ratio 2.4\u20132.6).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The incidence of adult-onset asthma has been stable over the last two decades and has remained at a similar level since the 1980s. The high incidence contributes to the increase in asthma prevalence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1183\/23120541.00262-2021","type":"journal-article","created":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T11:33:48Z","timestamp":1622115228000},"page":"00262-2021","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["High but stable incidence of adult-onset asthma in northern Sweden over the last decades"],"prefix":"10.1183","volume":"7","author":[{"given":"Petri","family":"R\u00e4is\u00e4nen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0553-8067","authenticated-orcid":false,"given":"Helena","family":"Backman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linnea","family":"Hedman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6622-3838","authenticated-orcid":false,"given":"Caroline","family":"Stridsman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannu","family":"Kankaanranta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8758-2431","authenticated-orcid":false,"given":"Pinja","family":"Ilmarinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5923-5865","authenticated-orcid":false,"given":"Heidi","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e4ivi","family":"Piiril\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Lindberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Lundb\u00e4ck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2358-8754","authenticated-orcid":false,"given":"Eva","family":"R\u00f6nmark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2021,5,27]]},"reference":[{"key":"2024101711104177000_7.3.00262-2021.1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1378\/chest.13-2059","article-title":"Trends in the prevalence of asthma","volume":"145","author":"Sears","year":"2014","journal-title":"Chest"},{"key":"2024101711104177000_7.3.00262-2021.2","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12963"},{"key":"2024101711104177000_7.3.00262-2021.3","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1111\/all.14177","article-title":"The need for clean air: the way air pollution and climate change affect allergic rhinitis and asthma","volume":"75","author":"Eguiluz-Gracia","year":"2020","journal-title":"Allergy"},{"key":"2024101711104177000_7.3.00262-2021.4","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00054304"},{"key":"2024101711104177000_7.3.00262-2021.5","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200611-1717OC"},{"key":"2024101711104177000_7.3.00262-2021.6","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1111\/cea.13181","article-title":"Novel genes and insights in complete asthma remission: a genome-wide association study on clinical and complete asthma remission","volume":"48","author":"Vonk","year":"2018","journal-title":"Clin Exp Allergy"},{"key":"2024101711104177000_7.3.00262-2021.7","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00620-2020"},{"key":"2024101711104177000_7.3.00262-2021.8","doi-asserted-by":"crossref","first-page":"246","DOI":"10.3389\/fped.2019.00246","article-title":"Epidemiology of asthma in children and adults","volume":"7","author":"Dharmage","year":"2019","journal-title":"Front Pediatr"},{"key":"2024101711104177000_7.3.00262-2021.9","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61447-6"},{"key":"2024101711104177000_7.3.00262-2021.10","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1398-9995.1998.tb03770.x","article-title":"Prevalence and incidence of asthma and rhinoconjunctivitis in Swedish teenagers","volume":"53","author":"Norrman","year":"1998","journal-title":"Allergy"},{"key":"2024101711104177000_7.3.00262-2021.11","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.312.7040.1195"},{"key":"2024101711104177000_7.3.00262-2021.12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1997.tb00178.x"},{"key":"2024101711104177000_7.3.00262-2021.13","doi-asserted-by":"publisher","DOI":"10.1136\/thx.43.7.534"},{"key":"2024101711104177000_7.3.00262-2021.14","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.7.2012143"},{"key":"2024101711104177000_7.3.00262-2021.15","doi-asserted-by":"publisher","DOI":"10.1053\/rmed.2001.1126"},{"key":"2024101711104177000_7.3.00262-2021.16","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.04.00044804"},{"key":"2024101711104177000_7.3.00262-2021.17","doi-asserted-by":"publisher","DOI":"10.1378\/chest.127.6.1928"},{"key":"2024101711104177000_7.3.00262-2021.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2008.07.011"},{"key":"2024101711104177000_7.3.00262-2021.19","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2011.04.013"},{"key":"2024101711104177000_7.3.00262-2021.20","doi-asserted-by":"publisher","DOI":"10.3109\/02770903.2011.637594"},{"key":"2024101711104177000_7.3.00262-2021.21","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00012813"},{"key":"2024101711104177000_7.3.00262-2021.22","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s12931-014-0135-9","article-title":"Asthma incidence, remission, relapse and persistence: a population-based study in southern Taiwan","volume":"15","author":"Wu","year":"2014","journal-title":"Respir Res"},{"key":"2024101711104177000_7.3.00262-2021.23","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1159\/000446509","article-title":"Smoking and new-onset asthma in a prospective study on Italian adults","volume":"170","author":"Verlato","year":"2016","journal-title":"Int Arch Allergy Immunol"},{"key":"2024101711104177000_7.3.00262-2021.24","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12890-019-1040-2","article-title":"Age-specific incidence of allergic and non-allergic asthma","volume":"20","author":"Pakkasela","year":"2020","journal-title":"BMC Pulm Med"},{"key":"2024101711104177000_7.3.00262-2021.25","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00041103"},{"key":"2024101711104177000_7.3.00262-2021.26","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1111\/all.13840","article-title":"Changes in the prevalence of asthma and respiratory symptoms in western Sweden between 2008 and 2016","volume":"74","author":"Borna","year":"2019","journal-title":"Allergy"},{"key":"2024101711104177000_7.3.00262-2021.27","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1398-9995.1993.tb00696.x","article-title":"Methacholine reactivity and asthma. Report from the Northern Sweden Obstructive Lung Disease Project","volume":"48","author":"Lundb\u00e4ck","year":"1993","journal-title":"Allergy"},{"key":"2024101711104177000_7.3.00262-2021.28","first-page":"603","article-title":"The incidence of adult asthma: a review","volume":"9","author":"Eagan","year":"2005","journal-title":"Int J Tuberc Lung Dis"},{"key":"2024101711104177000_7.3.00262-2021.29","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1513\/AnnalsATS.201212-115OC","article-title":"Adult-onset asthma becomes the dominant phenotype among women by age 40\u2005years","volume":"10","author":"Sood","year":"2013","journal-title":"Ann Am Thorac Soc"},{"key":"2024101711104177000_7.3.00262-2021.30","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1164\/ajrccm.162.1.9907008","article-title":"Differences in incidence of reported asthma related to age in men and women. A retrospective analysis of the data of the European Respiratory Health Survey","volume":"62","author":"de Marco","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"2024101711104177000_7.3.00262-2021.31","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1111\/all.12891","article-title":"Sex hormones and systemic inflammation are modulators of the obese-asthma phenotype","volume":"71","author":"Scott","year":"2016","journal-title":"Allergy"},{"key":"2024101711104177000_7.3.00262-2021.32","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1542\/peds.2013-0741","article-title":"Remission and persistence of asthma followed from 7 to 19\u2005years of age","volume":"132","author":"Andersson","year":"2013","journal-title":"Pediatrics"},{"key":"2024101711104177000_7.3.00262-2021.33","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022363"},{"key":"2024101711104177000_7.3.00262-2021.34","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2004.02.008"},{"key":"2024101711104177000_7.3.00262-2021.35","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00108105"},{"key":"2024101711104177000_7.3.00262-2021.36","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.rmed.2019.09.013","article-title":"18-yr cumulative incidence of respiratory\/allergic symptoms\/diseases and risk factors in the Pisa epidemiological study","volume":"158","author":"Maio","year":"2019","journal-title":"Respir Med"}],"container-title":["ERJ Open Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/23120541.00262-2021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:10:30Z","timestamp":1740355830000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/23120541.00262-2021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,27]]},"references-count":36,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,7,5]]},"published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1183\/23120541.00262-2021"],"URL":"https:\/\/doi.org\/10.1183\/23120541.00262-2021","relation":{},"ISSN":["2312-0541"],"issn-type":[{"value":"2312-0541","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,27]]}}}