{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T05:08:00Z","timestamp":1740460080208,"version":"3.37.3"},"reference-count":37,"publisher":"European Respiratory Society (ERS)","issue":"4","license":[{"start":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T00:00:00Z","timestamp":1600905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014438","name":"Business Finland","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100014438","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004092","name":"Kuopion Yliopistollinen Sairaala","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004092","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006706","name":"Tampereen Tuberkuloosis\u00e4\u00e4ti\u00d6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006706","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013506","name":"Kuopion Seudun Hengityss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013506","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010600","name":"Tays","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010600","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008309","name":"Hengityssairauksien Tutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008309","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019407","name":"Sein\u00e4joki Central Hospital","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100019407","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003125","name":"Suomen Kulttuurirahasto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007417","name":"Paulon S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007417","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004212","name":"P\u00e4ivikki ja Sakari Sohlbergin S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004212","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["ERJ Open Res"],"accepted":{"date-parts":[[2020,8,28]]},"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Besides hypoxaemia severity, heart rate variability has been linked to cognitive decline in obstructive sleep apnoea (OSA) patients. Thus, our aim was to examine whether the frequency domain features of a nocturnal photoplethysmogram (PPG) can be linked to poor performance in the psychomotor vigilance task (PVT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PPG signals from 567 suspected OSA patients, extracted from Type 1 diagnostic polysomnography, and corresponding results of PVT were retrospectively examined. The frequency content of complete PPGs was determined, and analyses were conducted separately for men (n=327) and women (n=240). Patients were grouped into PVT performance quartiles based on the number of lapses (reaction times \u2265500\u2005ms) and within-test variation in reaction times. The best-performing (Q1) and worst-performing (Q4) quartiles were compared due the lack of clinical thresholds in PVT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that the increase in arterial pulsation frequency (APF) in both men and women was associated with a higher number of lapses. Higher APF was also associated with higher within-test variation in men, but not in women. Median APF (\u03b2=0.27, p=0.01), time spent under 90% saturation (\u03b2=0.05, p&lt;0.01), female sex (\u03b2=1.29, p&lt;0.01), older age (\u03b2=0.03, p&lt;0.01) and subjective sleepiness (\u03b2=0.07, p&lt;0.01) were significant predictors of belonging to Q4 based on lapses. Only female sex (\u03b2=0.75, p&lt;0.01) and depression (\u03b2=0.91, p&lt;0.02) were significant predictors of belonging to Q4 based on the within-test variation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In conclusion, increased APF in PPG provides a possible polysomnography indicator for deteriorated vigilance especially in male OSA patients. This finding highlights the connection between cardiorespiratory regulation, vigilance and OSA. However, our results indicate substantial sex-dependent differences that warrant further prospective studies.<\/jats:p><\/jats:sec>","DOI":"10.1183\/23120541.00277-2020","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T21:00:20Z","timestamp":1600981220000},"page":"00277-2020","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Increased nocturnal arterial pulsation frequencies of obstructive sleep apnoea patients is associated with an increased number of lapses in a psychomotor vigilance task"],"prefix":"10.1183","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2798-2115","authenticated-orcid":false,"given":"Samu","family":"Kainulainen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3134-5138","authenticated-orcid":false,"given":"Brett","family":"Duce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4686-6112","authenticated-orcid":false,"given":"Henri","family":"Korkalainen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7918-9373","authenticated-orcid":false,"given":"Akseli","family":"Leino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8290-4764","authenticated-orcid":false,"given":"Riku","family":"Huttunen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8084-4160","authenticated-orcid":false,"given":"Laura","family":"Kalevo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0877-3529","authenticated-orcid":false,"given":"Erna S.","family":"Arnardottir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8252-3996","authenticated-orcid":false,"given":"Antti","family":"Kulkas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9779-4358","authenticated-orcid":false,"given":"Sami","family":"Myllymaa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8035-1606","authenticated-orcid":false,"given":"Juha","family":"T\u00f6yr\u00e4s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4017-821X","authenticated-orcid":false,"given":"Timo","family":"Lepp\u00e4nen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2020,9,24]]},"reference":[{"key":"2024101710523475000_6.4.00277-2020.1","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S2213-2600(19)30198-5","article-title":"Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis","volume":"7","author":"Benjafield","year":"2019","journal-title":"Lancet Respir Med"},{"key":"2024101710523475000_6.4.00277-2020.2","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.sleep.2016.03.006","article-title":"Moderate-to-severe obstructive sleep apnea is associated with cerebral small vessel disease","volume":"30","author":"Song","year":"2017","journal-title":"Sleep Med"},{"key":"2024101710523475000_6.4.00277-2020.3","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00043.2008"},{"key":"2024101710523475000_6.4.00277-2020.4","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s00702-015-1501-6","article-title":"Cognitive deficits in adults with obstructive sleep apnea compared to children and adolescents","volume":"124","author":"Krysta","year":"2017","journal-title":"J Neural Transm"},{"key":"2024101710523475000_6.4.00277-2020.5","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200408-1146OC"},{"key":"2024101710523475000_6.4.00277-2020.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.aap.2012.05.020"},{"key":"2024101710523475000_6.4.00277-2020.7","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.04.00091903"},{"key":"2024101710523475000_6.4.00277-2020.8","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.sleep.2016.08.024","article-title":"Sleep-related intermittent hypoxia is associated with decreased psychomotor vigilance in Japanese community residents","volume":"29","author":"Tanno","year":"2017","journal-title":"Sleep Med"},{"key":"2024101710523475000_6.4.00277-2020.9","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.5664\/jcsm.7806","article-title":"Severity of desaturations reflects OSA-related daytime sleepiness better than AHI","volume":"15","author":"Kainulainen","year":"2019","journal-title":"J Clin Sleep Med"},{"key":"2024101710523475000_6.4.00277-2020.10","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01849-2019"},{"key":"2024101710523475000_6.4.00277-2020.11","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000269522.84942.54"},{"key":"2024101710523475000_6.4.00277-2020.12","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000269512.82836.c9"},{"key":"2024101710523475000_6.4.00277-2020.13","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1007\/s40846-019-00468-9","article-title":"Evaluation of coherence between ECG and PPG derived parameters on heart rate variability and respiration in healthy volunteers with\/without controlled breathing","volume":"39","author":"Jan","year":"2019","journal-title":"J Med Biol Eng"},{"key":"2024101710523475000_6.4.00277-2020.14","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)90062-X"},{"key":"2024101710523475000_6.4.00277-2020.15","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2003.817636"},{"key":"2024101710523475000_6.4.00277-2020.16","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/hr.2015.38","article-title":"Impact of nocturnal heart rate variability on cerebral small-vessel disease progression: a longitudinal study in community-dwelling elderly Japanese","volume":"38","author":"Yamaguchi","year":"2015","journal-title":"Hypertens Res"},{"key":"2024101710523475000_6.4.00277-2020.17","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1088\/0967-3334\/31\/9\/015","article-title":"Photoplethysmography pulse rate variability as a surrogate measurement of heart rate variability during non-stationary conditions","volume":"31","author":"Gil","year":"2010","journal-title":"Physiol Meas"},{"key":"2024101710523475000_6.4.00277-2020.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2005.11.018"},{"key":"2024101710523475000_6.4.00277-2020.19","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.2172"},{"key":"2024101710523475000_6.4.00277-2020.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2013.10.024"},{"key":"2024101710523475000_6.4.00277-2020.21","first-page":"H2039","article-title":"Physiological time-series analysis using approximate entropy and sample entropy","volume":"278","author":"Richman","year":"2000","journal-title":"Am J Physiol"},{"key":"2024101710523475000_6.4.00277-2020.22","first-page":"H778","article-title":"Ventilatory, hemodynamic, sympathetic nervous system, and vascular reactivity changes after recurrent nocturnal sustained hypoxia in humans","volume":"295","author":"Gilmartin","year":"2008","journal-title":"Am J Physiol"},{"key":"2024101710523475000_6.4.00277-2020.23","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2008.10.003"},{"key":"2024101710523475000_6.4.00277-2020.24","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199816110-00010"},{"key":"2024101710523475000_6.4.00277-2020.25","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2014.07.028"},{"key":"2024101710523475000_6.4.00277-2020.26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.1998.tb00950.x"},{"key":"2024101710523475000_6.4.00277-2020.27","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s11325-016-1430-0","article-title":"Severity of individual obstruction events is gender dependent in sleep apnea","volume":"21","author":"Lepp\u00e4nen","year":"2017","journal-title":"Sleep Breath"},{"key":"2024101710523475000_6.4.00277-2020.28","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07318-3"},{"key":"2024101710523475000_6.4.00277-2020.29","doi-asserted-by":"publisher","DOI":"10.1126\/science.aax5440"},{"key":"2024101710523475000_6.4.00277-2020.30","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X15622047"},{"key":"2024101710523475000_6.4.00277-2020.31","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx148"},{"key":"2024101710523475000_6.4.00277-2020.32","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/ana.25408","article-title":"Obstructive sleep apnea treatment, slow wave activity, and amyloid-\u03b2","volume":"85","author":"Ju","year":"2019","journal-title":"Ann Neurol"},{"key":"2024101710523475000_6.4.00277-2020.33","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.6240"},{"key":"2024101710523475000_6.4.00277-2020.34","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpu045"},{"key":"2024101710523475000_6.4.00277-2020.35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061014"},{"key":"2024101710523475000_6.4.00277-2020.36","doi-asserted-by":"crossref","first-page":"13200","DOI":"10.1038\/s41598-019-49330-7","article-title":"Artificial neural network analysis of the oxygen saturation signal enables accurate diagnostics of sleep apnea","volume":"9","author":"Nikkonen","year":"2019","journal-title":"Sci Rep"},{"key":"2024101710523475000_6.4.00277-2020.37","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.2008.00665.x"}],"container-title":["ERJ Open Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/23120541.00277-2020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T05:04:03Z","timestamp":1740373443000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/23120541.00277-2020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,24]]},"references-count":37,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,11,16]]},"published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1183\/23120541.00277-2020"],"URL":"https:\/\/doi.org\/10.1183\/23120541.00277-2020","relation":{},"ISSN":["2312-0541"],"issn-type":[{"type":"electronic","value":"2312-0541"}],"subject":[],"published":{"date-parts":[[2020,9,24]]}}}