{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T08:18:17Z","timestamp":1787905097690,"version":"build-2784847793"},"reference-count":48,"publisher":"European Respiratory Society (ERS)","issue":"4","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R00NR014675"],"award-info":[{"award-number":["R00NR014675"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["ERJ Open Res"],"accepted":{"date-parts":[[2020,5,19]]},"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Sleepiness in obstructive sleep apnoea is associated with cardiovascular risk; however, the biological mechanisms are not known. This study explored whether those with subjective sleepiness have increased plasma tumour necrosis factor-related protein 1 (C1qTNF1), a novel adipose-derived hormone (adipokine), and 24-h ambulatory blood pressure (ABP) compared to those without sleepiness in newly diagnosed, treatment-na\u00efve participants with obstructive sleep apnoea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Overall, 94 participants were included in the analysis. Participants completed the Epworth Sleepiness Scale (ESS), 24-h ABP was monitored, and plasma C1qTNF1 was measured. Sleepy participants were defined as ESS\u226510 and nonsleepy as ESS&lt;10. Multiple linear regression was used to explore differences in C1qTNF1, and 24-h mean arterial pressure (MAP) between sleepy and nonsleepy participants, adjusting for age, sex, body mass index, apnoea\u2013hypopnoea index, and smoking status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>C1qTNF1 was significantly higher in sleepy participants (n=57) compared to nonsleepy participants (n=37) (\u03b2=0.41\u2005NPX, 95% CI 0.02, 0.80; p=0.04). The 24-h MAP was significantly higher in sleepy participants compared to nonsleepy participants (\u03b2=4.06\u2005mmHg, 95% CI 0.36, 7.77; p=0.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings show that sleepiness is associated with inflammation and higher 24-h MAP in sleep apnoea.<\/jats:p><\/jats:sec>","DOI":"10.1183\/23120541.00310-2019","type":"journal-article","created":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T13:50:32Z","timestamp":1603720232000},"page":"00310-2019","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Daytime sleepiness predicts inflammation and ambulatory blood pressure in sleep apnoea"],"prefix":"10.1183","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4081-8347","authenticated-orcid":false,"given":"Victoria 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