{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T09:18:33Z","timestamp":1788254313887,"version":"build-2803163510"},"reference-count":53,"publisher":"European Respiratory Society (ERS)","issue":"5","license":[{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010767","name":"Innovative Medicines Initiative","doi-asserted-by":"publisher","award":["EU-IMI 115010"],"award-info":[{"award-number":["EU-IMI 115010"]}],"id":[{"id":"10.13039\/501100010767","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["5U19AI070235"],"award-info":[{"award-number":["5U19AI070235"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["UG3OD035509"],"award-info":[{"award-number":["UG3OD035509"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["UG3OD035518"],"award-info":[{"award-number":["UG3OD035518"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["UH3OD023282"],"award-info":[{"award-number":["UH3OD023282"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["218505\/Z\/19\/Z"],"award-info":[{"award-number":["218505\/Z\/19\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["225221\/Z\/22\/Z"],"award-info":[{"award-number":["225221\/Z\/22\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIH","award":["5UH3OD023282"],"award-info":[{"award-number":["5UH3OD023282"]}]},{"name":"NIH","award":["R01MH129337"],"award-info":[{"award-number":["R01MH129337"]}]},{"name":"NIH","award":["U19 AI162310"],"award-info":[{"award-number":["U19 AI162310"]}]},{"name":"NIH","award":["U24AI179612"],"award-info":[{"award-number":["U24AI179612"]}]},{"name":"NIH","award":["UG3\/UH3 OD023282"],"award-info":[{"award-number":["UG3\/UH3 OD023282"]}]},{"name":"NIH","award":["UH3OD023282"],"award-info":[{"award-number":["UH3OD023282"]}]},{"name":"NIH","award":["UM1 AI160040"],"award-info":[{"award-number":["UM1 AI160040"]}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["U19 AI 095227"],"award-info":[{"award-number":["U19 AI 095227"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["U19 AI104317"],"award-info":[{"award-number":["U19 AI104317"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["U19 AI162310"],"award-info":[{"award-number":["U19 AI162310"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["U24AI179612"],"award-info":[{"award-number":["U24AI179612"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["UL1 TR002243"],"award-info":[{"award-number":["UL1 TR002243"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["UM1 AI114271"],"award-info":[{"award-number":["UM1 AI114271"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["UM1 AI160040"],"award-info":[{"award-number":["UM1 AI160040"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000362","name":"Asthma and Lung UK","doi-asserted-by":"publisher","award":["AUK-CDA-2019-414"],"award-info":[{"award-number":["AUK-CDA-2019-414"]}],"id":[{"id":"10.13039\/501100000362","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000362","name":"Asthma and Lung UK","doi-asserted-by":"publisher","award":["AUK-PG-2013-188"],"award-info":[{"award-number":["AUK-PG-2013-188"]}],"id":[{"id":"10.13039\/501100000362","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH129337"],"award-info":[{"award-number":["R01MH129337"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["ERJ Open Res"],"accepted":{"date-parts":[[2026,3,10]]},"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In \u223c10% of asthma patients, symptoms remain uncontrolled despite maximal treatment, representing an unmet clinical need. The causal variants, genes and pathways underlying genetic risk factors have not been fully elucidated, and it is unclear whether there are unique genetic risk factors for this asthma subtype.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We used electronic healthcare records linked to UK Biobank to identify asthma patients with high treatment burden and\/or worse outcomes. We performed a genome-wide association study (GWAS) with this case population and healthy controls. We sought replication for associated (p\u22645\u00d710\n                      <jats:sup>\u22126<\/jats:sup>\n                      ) signals in four independent studies (12\u2009152 cases and 32\u2009316 controls). Replicated signals were fine-mapped and linked to genes and pathways.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 7681 participants met our case definition and showed enrichment for adult-onset asthma, female gender and higher body mass index compared to asthma individuals not meeting case criteria. GWAS with 7681 cases and 38\u2009405 controls revealed 21 reproducible association signals that had previously been associated with asthma, but had a larger effect size in our study. Variant-to-gene mapping highlighted 85 candidate genes, five of which were considered high confidence (\n                      <jats:italic>BACH2<\/jats:italic>\n                      ,\n                      <jats:italic>D2HGDH<\/jats:italic>\n                      ,\n                      <jats:italic>IL1RL1<\/jats:italic>\n                      ,\n                      <jats:italic>RPS26<\/jats:italic>\n                      ,\n                      <jats:italic>SMAD3<\/jats:italic>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We present the first use of electronic healthcare records in UK Biobank to identify a subtype of asthma enriched for patients with high treatment burden and\/or worse outcomes. Our findings support the role of known asthma genes, highlighting genetic risk variants with stronger effect in these groups of patients. The prioritised genes provide potential therapeutic opportunities for this difficult-to-treat patient population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1183\/23120541.00327-2026","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T15:45:12Z","timestamp":1776959112000},"page":"00327-2026","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Genome-wide association study of asthma with high treatment burden and\/or worse outcomes defined using electronic healthcare data in UK Biobank"],"prefix":"10.1183","volume":"12","author":[{"given":"Noemi N.","family":"Piga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Portelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3641-4371","authenticated-orcid":false,"given":"Nick","family":"Shrine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2459-1020","authenticated-orcid":false,"given":"Richard","family":"Packer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4951-6799","authenticated-orcid":false,"given":"Kayesha","family":"Coley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander T.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Batini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6057-2073","authenticated-orcid":false,"given":"Catherine","family":"John","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon M.","family":"Lutz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten R.","family":"Voorhies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert M.","family":"Levin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazanin","family":"Zounemat-Kermani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6667-4708","authenticated-orcid":false,"given":"James E.","family":"Gern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8789-418X","authenticated-orcid":false,"given":"Diane R.","family":"Gold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina V.","family":"Hartert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine C.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurjit K.","family":"Khurana Hershey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel L.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine M.","family":"Seroogy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward M.","family":"Zoratti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Don D.","family":"Sin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten","family":"van den Berge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3067-3711","authenticated-orcid":false,"given":"Yohan","family":"Boss\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominick","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zara E. K.","family":"Pogson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Fogarty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liam G.","family":"Heaney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8615-8778","authenticated-orcid":false,"given":"Adel H.","family":"Mansur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rekha","family":"Chaudhuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil C.","family":"Thomson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9998-0464","authenticated-orcid":false,"given":"John W.","family":"Holloway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7101-1426","authenticated-orcid":false,"given":"Kian Fan","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Blakey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4951-1867","authenticated-orcid":false,"given":"Louise V.","family":"Wain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Ober","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann C.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2101-8843","authenticated-orcid":false,"given":"Ian M.","family":"Adcock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian P.","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher E.","family":"Brightling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenda","family":"Lassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5601-5410","authenticated-orcid":false,"given":"Ian","family":"Sayers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6675-2112","authenticated-orcid":false,"given":"Katherine A.","family":"Fawcett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2026,4,23]]},"reference":[{"key":"2026090101501594000_12.5.00327-2026.1","unstructured":"Scottish Intercollegiate Guidelines Network , British Thoracic Society , Healthcare Improvement Society . British Guideline on the Management of Asthma: A National Clinical Guideline. Edinburgh, Healthcare Improvement Scotland, 2019."},{"key":"2026090101501594000_12.5.00327-2026.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)02125-0"},{"key":"2026090101501594000_12.5.00327-2026.3","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.iac.2024.07.007","article-title":"Real-world studies of biologics for the treatment of moderate-to-severe asthma","volume":"44","author":"Desai","year":"2024","journal-title":"Immunol Allergy Clin North Am"},{"key":"2026090101501594000_12.5.00327-2026.4","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-024-00695-0"},{"key":"2026090101501594000_12.5.00327-2026.5","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/j.1752-699X.2011.00273.x","article-title":"A study of asthma severity in adult twins","volume":"6","author":"Thomsen","year":"2012","journal-title":"Clin Respir J"},{"key":"2026090101501594000_12.5.00327-2026.6","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-09447-8"},{"key":"2026090101501594000_12.5.00327-2026.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.11.018"},{"key":"2026090101501594000_12.5.00327-2026.8","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/S2213-2600(18)30389-8","article-title":"Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study","volume":"7","author":"Shrine","year":"2019","journal-title":"Lancet Respir Med"},{"key":"2026090101501594000_12.5.00327-2026.9","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2011-201262"},{"key":"2026090101501594000_12.5.00327-2026.10","doi-asserted-by":"crossref","first-page":"100212","DOI":"10.1016\/j.xgen.2022.100212","article-title":"Multi-ancestry meta-analysis of asthma identifies novel associations and highlights the value of increased power and diversity","volume":"2","author":"Tsuo","year":"2022","journal-title":"Cell Genom"},{"key":"2026090101501594000_12.5.00327-2026.11","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0579-z"},{"key":"2026090101501594000_12.5.00327-2026.12","unstructured":"National Academies of Sciences Engineering, and Medicine . Using Population Descriptors in Genetics and Genomics Research: A New Framework for an Evolving Field. Washington, National Academies Press, 2023."},{"key":"2026090101501594000_12.5.00327-2026.13","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-023-01314-0"},{"key":"2026090101501594000_12.5.00327-2026.14","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3643"},{"key":"2026090101501594000_12.5.00327-2026.15","doi-asserted-by":"publisher","DOI":"10.1038\/nature14962"},{"key":"2026090101501594000_12.5.00327-2026.16","doi-asserted-by":"publisher","DOI":"10.1038\/nature15393"},{"key":"2026090101501594000_12.5.00327-2026.17","doi-asserted-by":"publisher","DOI":"10.1038\/S41588-021-00870-7"},{"key":"2026090101501594000_12.5.00327-2026.18","doi-asserted-by":"crossref","first-page":"731","DOI":"10.21105\/joss.00731","article-title":"qqman: an R package for visualizing GWAS results using Q-Q and manhattan plots","volume":"3","author":"Turner","year":"2018","journal-title":"J Open Source Software"},{"key":"2026090101501594000_12.5.00327-2026.19","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3211"},{"key":"2026090101501594000_12.5.00327-2026.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2010.11.011"},{"key":"2026090101501594000_12.5.00327-2026.21","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.115.178616"},{"key":"2026090101501594000_12.5.00327-2026.22","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00779-2015"},{"key":"2026090101501594000_12.5.00327-2026.23","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s12931-019-1088-9","article-title":"The Children's Respiratory and Environmental Workgroup (CREW) birth cohort consortium: design, methods, and study population","volume":"20","author":"Gern","year":"2019","journal-title":"Respir Res"},{"key":"2026090101501594000_12.5.00327-2026.24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2023.03.016"},{"key":"2026090101501594000_12.5.00327-2026.25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2011.04.014"},{"key":"2026090101501594000_12.5.00327-2026.26","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00566-2023"},{"key":"2026090101501594000_12.5.00327-2026.27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1010299"},{"key":"2026090101501594000_12.5.00327-2026.28","doi-asserted-by":"publisher","DOI":"10.1101\/gr.135350.111"},{"key":"2026090101501594000_12.5.00327-2026.29","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky955"},{"key":"2026090101501594000_12.5.00327-2026.30","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac966"},{"key":"2026090101501594000_12.5.00327-2026.31","doi-asserted-by":"publisher","DOI":"10.1093\/NAR\/GKAC1000"},{"key":"2026090101501594000_12.5.00327-2026.32","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/S2213-2600(25)00256-5","article-title":"Genetic and environmental risk factors for asthma: towards prevention","volume":"13","author":"Koppelman","year":"2025","journal-title":"Lancet Respir Med"},{"key":"2026090101501594000_12.5.00327-2026.33","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/S2213-2600(21)00537-3","article-title":"Evaluation of the oral corticosteroid-sparing effect of tezepelumab in adults with oral corticosteroid-dependent asthma (SOURCE): a randomised, placebo-controlled, phase 3 study","volume":"10","author":"Wechsler","year":"2022","journal-title":"Lancet Respir Med"},{"key":"2026090101501594000_12.5.00327-2026.34","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2016.03.032"},{"key":"2026090101501594000_12.5.00327-2026.35","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31324-1"},{"key":"2026090101501594000_12.5.00327-2026.36","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0144-2022"},{"key":"2026090101501594000_12.5.00327-2026.37","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.11.7310"},{"key":"2026090101501594000_12.5.00327-2026.38","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/s42003-021-02227-6","article-title":"Prioritization of candidate causal genes for asthma in susceptibility loci derived from UK Biobank","volume":"4","author":"Valette","year":"2021","journal-title":"Commun Biol"},{"key":"2026090101501594000_12.5.00327-2026.39","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203716"},{"key":"2026090101501594000_12.5.00327-2026.40","doi-asserted-by":"crossref","first-page":"738741","DOI":"10.3389\/falgy.2021.738741","article-title":"Translational analysis of moderate to severe asthma GWAS signals into candidate causal genes and their functional, tissue-dependent and disease-related associations","volume":"2","author":"Portelli","year":"2021","journal-title":"Front Allergy"},{"key":"2026090101501594000_12.5.00327-2026.41","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20031933"},{"key":"2026090101501594000_12.5.00327-2026.42","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005548005393"},{"key":"2026090101501594000_12.5.00327-2026.43","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0121-0"},{"key":"2026090101501594000_12.5.00327-2026.44","doi-asserted-by":"crossref","first-page":"3014","DOI":"10.1111\/all.15809","article-title":"D-2-hydroxyglutarate suppresses allergic sensitization in a murine model of experimental asthma","volume":"78","author":"Tharakan","year":"2023","journal-title":"Allergy"},{"key":"2026090101501594000_12.5.00327-2026.45","first-page":"838","article-title":"Kartirovanie genov ribosomnykh belkov S26, L19, i L32 na khromosomakh cheloveka. [Mapping of the genes for ribosomal proteins S26, L19, and L32 on human chromosomes]","volume":"21","author":"Filipenko","year":"1995","journal-title":"Bioorg Khim"},{"key":"2026090101501594000_12.5.00327-2026.46","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2018.10.027"},{"key":"2026090101501594000_12.5.00327-2026.47","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac1046"},{"key":"2026090101501594000_12.5.00327-2026.48","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-025-01459-z"},{"key":"2026090101501594000_12.5.00327-2026.49","doi-asserted-by":"publisher","DOI":"10.1111\/pai.13802"},{"key":"2026090101501594000_12.5.00327-2026.50","doi-asserted-by":"crossref","first-page":"191","DOI":"10.4168\/aair.2017.9.3.191","article-title":"Genetic signatures of asthma exacerbation","volume":"9","author":"Park","year":"2017","journal-title":"Allergy Asthma Immunol Res"},{"key":"2026090101501594000_12.5.00327-2026.51","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02693-2020"},{"key":"2026090101501594000_12.5.00327-2026.52","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.08.020"},{"key":"2026090101501594000_12.5.00327-2026.53","unstructured":"Global Initiative for Asthma (GINA) . Global Strategy for Asthma Management and Prevention, 2022. Date last updated: 2022. https:\/\/ginasthma.org\/wp-content\/uploads\/2023\/05\/GINA-Main-Report-2022-WMSA.pdf"}],"container-title":["ERJ Open Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/23120541.00327-2026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T08:50:26Z","timestamp":1788252626000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/23120541.00327-2026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,23]]},"references-count":53,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,9,1]]},"published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1183\/23120541.00327-2026"],"URL":"https:\/\/doi.org\/10.1183\/23120541.00327-2026","relation":{},"ISSN":["2312-0541"],"issn-type":[{"value":"2312-0541","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,23]]}}}