{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:11:14Z","timestamp":1791389474963,"version":"4.3.3"},"reference-count":52,"publisher":"European Respiratory Society (ERS)","issue":"4","license":[{"start":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T00:00:00Z","timestamp":1663804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["ERJ Open Res"],"accepted":{"date-parts":[[2022,8,17]]},"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:p>Non-cystic fibrosis bronchiectasis (NCFB) is a highly prevalent chronic respiratory disease with substantial burden to both patients and healthcare systems. Persons with NCFB (pwNCFB) are often given complex acute and chronic treatment regimens consisting of medications, airway clearance techniques and exercise. Accordingly, the high burden in NCFB has contributed to lower therapy adherence, with estimates of 53% to medications, 41% to airway clearance and only 16% to all prescribed therapy. Consequent clinical outcomes from lower adherence include reduced quality of life, accelerated lung function decline and recurrent pulmonary exacerbations. In this narrative review, we explore the impact of multifactorial mechanisms underpinning adherence in NCFB and evaluate the available evidence towards interventions to improve uptake of therapy as demonstrated in other chronic respiratory diseases. A holistic approach, starting with a careful review of patient adherence at regular intervals, may increase the success of multidimensional therapeutic interventions in pwNCFB, but robust ongoing studies are an area of need in this population.<\/jats:p>","DOI":"10.1183\/23120541.00340-2022","type":"journal-article","created":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T14:35:21Z","timestamp":1663857321000},"page":"00340-2022","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Assessment of factors and interventions towards therapeutic adherence among persons with non-cystic fibrosis bronchiectasis"],"prefix":"10.1183","volume":"8","author":[{"given":"Christina S.","family":"Thornton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjani","family":"Somayaji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel K.","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2022,9,22]]},"reference":[{"key":"2024101711413704000_8.4.00340-2022.1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ccm.2021.12.001","article-title":"Bronchiectasis from 2012 to 2022","volume":"43","author":"Chalmers","year":"2022","journal-title":"Clin Chest Med"},{"key":"2024101711413704000_8.4.00340-2022.2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01033-2015"},{"key":"2024101711413704000_8.4.00340-2022.3","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ccm.2021.11.001","article-title":"Diagnosis and evaluation of bronchiectasis","volume":"43","author":"Cohen","year":"2022","journal-title":"Clin Chest Med"},{"key":"2024101711413704000_8.4.00340-2022.4","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1002\/ppul.24491","article-title":"Children with bronchiectasis have poorer lung function than those with cystic fibrosis and do not receive the same standard of care","volume":"54","author":"Prentice","year":"2019","journal-title":"Pediatr Pulmonol"},{"key":"2024101711413704000_8.4.00340-2022.5","doi-asserted-by":"crossref","first-page":"xiii","DOI":"10.1016\/j.ccm.2022.01.001","article-title":"Bronchiectasis: advances in diagnosis and management","volume":"43","author":"Chalmers","year":"2022","journal-title":"Clin Chest Med"},{"key":"2024101711413704000_8.4.00340-2022.6","doi-asserted-by":"publisher","DOI":"10.1097\/01.cpm.0000171422.98696.ed"},{"key":"2024101711413704000_8.4.00340-2022.7","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00105513"},{"key":"2024101711413704000_8.4.00340-2022.8","doi-asserted-by":"publisher","DOI":"10.1183\/20734735.0022-2021"},{"key":"2024101711413704000_8.4.00340-2022.9","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1001\/jama.2018.19271","article-title":"Interventions to improve medication adherence: a review","volume":"320","author":"Kini","year":"2018","journal-title":"JAMA"},{"key":"2024101711413704000_8.4.00340-2022.10","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/1471-2466-14-107","article-title":"Treatment adherence and health outcomes in patients with bronchiectasis","volume":"14","author":"McCullough","year":"2014","journal-title":"BMC Pulm Med"},{"key":"2024101711413704000_8.4.00340-2022.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2008.09.007"},{"key":"2024101711413704000_8.4.00340-2022.12","doi-asserted-by":"crossref","first-page":"S3428","DOI":"10.21037\/jtd.2018.09.39","article-title":"Medical management of bronchiectasis","volume":"10","author":"O'Donnell","year":"2018","journal-title":"J Thorac Dis"},{"key":"2024101711413704000_8.4.00340-2022.13","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ccm.2021.12.005","article-title":"Future directions in bronchiectasis research","volume":"43","author":"Amaro","year":"2022","journal-title":"Clin Chest Med"},{"key":"2024101711413704000_8.4.00340-2022.14","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.ccm.2021.12.004","article-title":"Airway clearance and mucoactive therapies in bronchiectasis","volume":"43","author":"O'Donnell","year":"2022","journal-title":"Clin Chest Med"},{"key":"2024101711413704000_8.4.00340-2022.15","doi-asserted-by":"publisher","DOI":"10.1136\/bmjresp-2018-000348"},{"key":"2024101711413704000_8.4.00340-2022.16","first-page":"CD003572","article-title":"Short acting beta2-agonists for bronchiectasis","volume":"1","author":"Franco","year":"2003","journal-title":"Cochrane Database Syst Rev"},{"key":"2024101711413704000_8.4.00340-2022.17","first-page":"54","article-title":"The importance of inhaler adherence to prevent COPD exacerbations","volume":"7","author":"Jardim","year":"2019","journal-title":"Med Sci"},{"key":"2024101711413704000_8.4.00340-2022.18","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60953-2"},{"key":"2024101711413704000_8.4.00340-2022.19","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.1937"},{"key":"2024101711413704000_8.4.00340-2022.20","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.2290"},{"key":"2024101711413704000_8.4.00340-2022.21","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01987-2017"},{"key":"2024101711413704000_8.4.00340-2022.22","first-page":"481","article-title":"Systematic review on adherence, barriers to treatment and impact of airway clearance in bronchiectasis","volume":"4","author":"Low","year":"2020","journal-title":"Arch Clin Biomed Res"},{"key":"2024101711413704000_8.4.00340-2022.23","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201312-2208OC"},{"key":"2024101711413704000_8.4.00340-2022.24","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s12874-017-0411-8","article-title":"Measuring the burden of treatment for chronic disease: implications of a scoping review of the literature","volume":"17","author":"Sav","year":"2017","journal-title":"BMC Med Res Methodol"},{"key":"2024101711413704000_8.4.00340-2022.25","doi-asserted-by":"publisher","DOI":"10.1111\/hex.12046"},{"key":"2024101711413704000_8.4.00340-2022.26","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2803"},{"key":"2024101711413704000_8.4.00340-2022.27","first-page":"CD011023","article-title":"Interventions for enhancing adherence to treatment in adults with bronchiectasis","volume":"11","author":"McCullough","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"2024101711413704000_8.4.00340-2022.28","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2011.03.012"},{"key":"2024101711413704000_8.4.00340-2022.29","doi-asserted-by":"crossref","first-page":"1479973120948077","DOI":"10.1177\/1479973120948077","article-title":"Randomised controlled trial of the effect, cost and acceptability of a bronchiectasis self-management intervention","volume":"17","author":"Brockwell","year":"2020","journal-title":"Chron Respir Dis"},{"key":"2024101711413704000_8.4.00340-2022.30","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1186\/s12913-015-1004-z","article-title":"Defining the content and delivery of an intervention to Change AdhereNce to treatment in BonchiEctasis (CAN-BE): a qualitative approach incorporating the Theoretical Domains Framework, behavioural change techniques and stakeholder expert panels","volume":"15","author":"McCullough","year":"2015","journal-title":"BMC Health Serv Res"},{"key":"2024101711413704000_8.4.00340-2022.31","doi-asserted-by":"publisher","DOI":"10.1183\/20734735.0006-2021"},{"key":"2024101711413704000_8.4.00340-2022.32","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2017.10.111"},{"key":"2024101711413704000_8.4.00340-2022.33","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2013.11.005"},{"key":"2024101711413704000_8.4.00340-2022.34","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.congress-2018.PA2952"},{"key":"2024101711413704000_8.4.00340-2022.35","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1080\/15412555.2020.1833852","article-title":"What is the impact of outreach services on medication adherence for COPD patients? A systematic review","volume":"17","author":"Marron","year":"2020","journal-title":"COPD"},{"key":"2024101711413704000_8.4.00340-2022.36","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.jaci.2011.05.010","article-title":"Problem solving to improve adherence and asthma outcomes in urban adults with moderate or severe asthma: a randomized controlled trial","volume":"128","author":"Apter","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"2024101711413704000_8.4.00340-2022.37","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1093\/inthealth\/ihy050","article-title":"Asthma action plan for proactive bronchial asthma self-management in adults: a randomized controlled trial","volume":"10","author":"Farag","year":"2018","journal-title":"Int Health"},{"key":"2024101711413704000_8.4.00340-2022.38","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011682.pub2"},{"key":"2024101711413704000_8.4.00340-2022.39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.11.700"},{"key":"2024101711413704000_8.4.00340-2022.40","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.05.041"},{"key":"2024101711413704000_8.4.00340-2022.41","doi-asserted-by":"crossref","first-page":"44","DOI":"10.5588\/ijtld.21.0373","article-title":"A randomised controlled trial to evaluate a medication monitoring system for TB treatment","volume":"26","author":"Acosta","year":"2022","journal-title":"Int J Tuberc Lung Dis"},{"key":"2024101711413704000_8.4.00340-2022.42","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00063205"},{"key":"2024101711413704000_8.4.00340-2022.43","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00015603"},{"key":"2024101711413704000_8.4.00340-2022.44","first-page":"46","article-title":"Striving for perfection, accepting the reality: a reflection on adherence to airway clearance and inhalation therapy for paediatric patients with chronic suppurative lung disease","volume":"34","author":"Dixon","year":"2020","journal-title":"Paediatr Respir Rev"},{"key":"2024101711413704000_8.4.00340-2022.45","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1513\/AnnalsATS.201603-222OC","article-title":"A method to calculate adherence to inhaled therapy that reflects the changes in clinical features of asthma","volume":"13","author":"Sulaiman","year":"2016","journal-title":"Ann Am Thorac Soc"},{"key":"2024101711413704000_8.4.00340-2022.46","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.1016\/S1569-1993(14)60093-X","article-title":"WS14.6 Feasibility study to objectively measure airway clearance technique in cystic fibrosis","volume":"13","author":"Hoo","year":"2014","journal-title":"J Cystic Fibrosis"},{"key":"2024101711413704000_8.4.00340-2022.47","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-3074"},{"key":"2024101711413704000_8.4.00340-2022.48","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s12890-021-01500-y","article-title":"A multi-centre, randomized, controlled trial on coaching and telemonitoring in patients with cystic fibrosis: conneCT CF","volume":"21","author":"Thee","year":"2021","journal-title":"BMC Pulm Med"},{"key":"2024101711413704000_8.4.00340-2022.49","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1056\/NEJMoa2021713","article-title":"Phase 2 trial of the DPP-1 inhibitor brensocatib in bronchiectasis","volume":"383","author":"Chalmers","year":"2020","journal-title":"N Engl J Med"},{"key":"2024101711413704000_8.4.00340-2022.50","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2011.04167.x"},{"key":"2024101711413704000_8.4.00340-2022.51","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4733.2007.00213.x"},{"key":"2024101711413704000_8.4.00340-2022.52","doi-asserted-by":"publisher","DOI":"10.1111\/hex.12217"}],"container-title":["ERJ Open Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/23120541.00340-2022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T05:21:01Z","timestamp":1740374461000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/23120541.00340-2022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,22]]},"references-count":52,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,11,7]]},"published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1183\/23120541.00340-2022"],"URL":"https:\/\/doi.org\/10.1183\/23120541.00340-2022","relation":{},"ISSN":["2312-0541"],"issn-type":[{"value":"2312-0541","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,22]]}}}