{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T06:01:17Z","timestamp":1790920877875,"version":"4.1.0"},"reference-count":23,"publisher":"European Respiratory Society (ERS)","issue":"4","license":[{"start":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T00:00:00Z","timestamp":1661299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["10430022010026"],"award-info":[{"award-number":["10430022010026"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["ERJ Open Res"],"accepted":{"date-parts":[[2022,7,23]]},"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>A large proportion of patients experience a wide range of sequelae after acute COVID-19, especially after severe illness. The long-term health sequelae need to be assessed. Our objective was to longitudinally assess persistence of symptoms and clusters of symptoms up to 12\u2005months after hospitalisation for COVID-19 and to assess determinants of the main persistent symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this multicenter prospective cohort study patients with COVID-19 are followed up for 2\u2005years with measurements at 3, 6, 12 and 24\u2005months after hospital discharge. Here, we present interim results regarding persistent symptoms up to 12\u2005months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 492 patients; mean\u00b1\n                      <jats:sc>sd<\/jats:sc>\n                      age was 60.2\u00b110.7\u2005years, 335 (68.1%) were males, median length of hospital stay was 11 (6.0\u201327.0) days. At 3\u2005months after discharge 97.0% of the patients had at least one persisting symptom, this declined to 95.5% and 92.0% at 6 and 12 months, respectively (p=0.010). Muscle weakness, exertional dyspnoea, fatigue, and memory and concentration problems were the most prevalent symptoms with rates over 50% during follow-up. Over time, muscle weakness, hair loss and exertional dyspnoea decreased significantly (p&lt;0.001), while other symptoms such as fatigue, concentration and memory problems, anosmia and ageusia persisted. Symptoms from the physical and respiratory cluster declined significantly over time, in contrast to the fatigue and cognitive symptom clusters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The majority of patients experienced COVID-19 sequelae up to 12\u2005months after severe infection. Whereas physical and respiratory symptoms showed slow gradual decline, fatigue and cognitive symptoms did not evidently resolve over time.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1183\/23120541.00355-2022","type":"journal-article","created":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T02:25:14Z","timestamp":1661394314000},"page":"00355-2022","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":24,"title":["Symptoms persisting after hospitalisation for COVID-19: 12 months interim results of the CO-FLOW study"],"prefix":"10.1183","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8257-7070","authenticated-orcid":false,"given":"L. Martine","family":"Bek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia C.","family":"Berentschot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2982-4404","authenticated-orcid":false,"given":"Majanka H.","family":"Heijenbrok-Kal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6652-6254","authenticated-orcid":false,"given":"Susanne","family":"Huijts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5668-3435","authenticated-orcid":false,"given":"Michel E.","family":"van Genderen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Hans","family":"Vlake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8408-0500","authenticated-orcid":false,"given":"Jasper","family":"van Bommel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6662-2951","authenticated-orcid":false,"given":"Joachim G.J.V.","family":"Aerts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6114-349X","authenticated-orcid":false,"given":"Gerard M.","family":"Ribbers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6433-3398","authenticated-orcid":false,"given":"Rita J.G.","family":"van den Berg-Emons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6666-5027","authenticated-orcid":false,"given":"Merel E.","family":"Hellemons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2022,8,24]]},"reference":[{"key":"2024101711400621000_8.4.00355-2022.1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.12839.e4"},{"key":"2024101711400621000_8.4.00355-2022.2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m3026"},{"key":"2024101711400621000_8.4.00355-2022.3","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n136"},{"key":"2024101711400621000_8.4.00355-2022.4","unstructured":"WHO . A clinical case definition of post COVID-19 condition by a Delphi consensus. www.who.int\/publications\/i\/item\/WHO-2019-nCoV-Post_COVID-19_condition-Clinical_case_definition-2021.1"},{"key":"2024101711400621000_8.4.00355-2022.5","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01292-y"},{"key":"2024101711400621000_8.4.00355-2022.6","doi-asserted-by":"crossref","unstructured":"van der Maaden T , Mutubuki EN , de Bruijn S , et al. Prevalence and severity of symptoms 3 months after infection with SARS-CoV-2 compared to test-negative and population controls in the Netherlands. medRxiv 2022; preprint [ https:\/\/doi.org\/10.1101\/2022.06.15.22276439].","DOI":"10.1101\/2022.06.15.22276439"},{"key":"2024101711400621000_8.4.00355-2022.7","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1513\/AnnalsATS.202103-340OC","article-title":"Persistent health problems beyond pulmonary recovery up to 6 months after hospitalization for SARS-CoV-2; a longitudinal study of respiratory, physical and psychological outcomes","volume":"19","author":"Hellemons","year":"2022","journal-title":"Ann Am Thorac Soc"},{"key":"2024101711400621000_8.4.00355-2022.8","doi-asserted-by":"crossref","first-page":"e2128568-e","DOI":"10.1001\/jamanetworkopen.2021.28568","article-title":"Short-term and long-term rates of postacute sequelae of SARS-CoV-2 infection: a systematic review","volume":"4","author":"Groff","year":"2021","journal-title":"JAMA Netw Open"},{"key":"2024101711400621000_8.4.00355-2022.9","doi-asserted-by":"crossref","unstructured":"Huang L , Li X , Gu X , et al. Health outcomes in people 2 years after surviving hospitalisation with COVID-19: a longitudinal cohort study. Lancet Respir Med 2022; in press [https:\/\/doi.org\/10.1016\/S2213-2600(22)00126-6].","DOI":"10.1016\/S2213-2600(22)00126-6"},{"key":"2024101711400621000_8.4.00355-2022.10","doi-asserted-by":"crossref","first-page":"834354","DOI":"10.3389\/fmed.2022.834354","article-title":"Patient-reported symptoms and sequelae 12 months after COVID-19 in hospitalized adults: a multicenter long-term follow-up study","volume":"9","author":"Comelli","year":"2022","journal-title":"Front Med (Lausanne)"},{"key":"2024101711400621000_8.4.00355-2022.11","doi-asserted-by":"crossref","first-page":"101019","DOI":"10.1016\/j.eclinm.2021.101019","article-title":"Characterizing long COVID in an international cohort: 7 months of symptoms and their impact","volume":"38","author":"Davis","year":"2021","journal-title":"EClinicalMedicine"},{"key":"2024101711400621000_8.4.00355-2022.12","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1186\/s12916-021-02115-0","article-title":"Evolving phenotypes of non-hospitalized patients that indicate long COVID","volume":"19","author":"Estiri","year":"2021","journal-title":"BMC Med"},{"key":"2024101711400621000_8.4.00355-2022.13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003773"},{"key":"2024101711400621000_8.4.00355-2022.14","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-021-06813-6"},{"key":"2024101711400621000_8.4.00355-2022.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2011.05.004"},{"key":"2024101711400621000_8.4.00355-2022.16","doi-asserted-by":"crossref","unstructured":"Wynberg E , van Willigen H , Dijkstra M , et al. Evolution of COVID-19 symptoms during the first 9 months after illness onset. medRxiv 2021; preprint [https:\/\/doi.org\/10.1101\/2021.05.05.21256710].","DOI":"10.1101\/2021.05.05.21256710"},{"key":"2024101711400621000_8.4.00355-2022.17","doi-asserted-by":"crossref","first-page":"e210830","DOI":"10.1001\/jamanetworkopen.2021.0830","article-title":"Sequelae in adults at 6 months after COVID-19 infection","volume":"4","author":"Logue","year":"2021","journal-title":"JAMA Netw Open"},{"key":"2024101711400621000_8.4.00355-2022.18","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S2213-2600(22)00127-8","article-title":"Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study","volume":"10","year":"2022","journal-title":"Lancet Respir Med"},{"key":"2024101711400621000_8.4.00355-2022.19","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01433-3"},{"key":"2024101711400621000_8.4.00355-2022.20","doi-asserted-by":"crossref","first-page":"e0211532","DOI":"10.1371\/journal.pone.0211532","article-title":"Age and sex related self-reported symptoms in a general population across 30 years: patterns of reporting and secular trend","volume":"14","author":"Bardel","year":"2019","journal-title":"PLoS One"},{"key":"2024101711400621000_8.4.00355-2022.21","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S1473-3099(21)00460-6","article-title":"Risk factors and disease profile of post-vaccination SARS-CoV-2 infection in UK users of the COVID Symptom Study app: a prospective, community-based, nested, case-control study","volume":"22","author":"Antonelli","year":"2021","journal-title":"Lancet Infect Dis"},{"key":"2024101711400621000_8.4.00355-2022.22","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01283-z"},{"key":"2024101711400621000_8.4.00355-2022.23","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1209390"}],"container-title":["ERJ Open Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/23120541.00355-2022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:20:43Z","timestamp":1740356443000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/23120541.00355-2022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,24]]},"references-count":23,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,10,24]]},"published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1183\/23120541.00355-2022"],"URL":"https:\/\/doi.org\/10.1183\/23120541.00355-2022","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.12.11.21267652","asserted-by":"object"}]},"ISSN":["2312-0541"],"issn-type":[{"value":"2312-0541","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,24]]}}}