{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T05:10:02Z","timestamp":1788930602585,"version":"build-2803163510"},"reference-count":44,"publisher":"European Respiratory Society (ERS)","issue":"2","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["ERJ Open Res"],"accepted":{"date-parts":[[2020,4,22]]},"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:p>Diagnosis of asthma in obese individuals frequently relies on clinical history, as airflow by spirometry may remain normal. This study hypothesised that obese subjects with self-reported asthma and normal spirometry will demonstrate distinct clinical characteristics, metabolic comorbidities and enhanced small airway dysfunction as compared with healthy obese subjects.<\/jats:p><jats:p>Spirometry, plethysmography and oscillometry data pre\/post-bronchodilator were obtained in 357 obese subjects in three groups as follows: no asthma group (n=180), self-reported asthma normal spirometry group (n=126), and asthma obstructed spirometry group (n=51). To assess the effects of obesity related to reduced lung volume, oscillometry measurements were repeated during a voluntary inflation to predicted functional residual capacity (FRC).<\/jats:p><jats:p>Dyspnoea was equally prevalent in all groups. In contrast, cough, wheeze and metabolic comorbidities were more frequent in the asthma normal spirometry and asthma obstructed spirometry groups<jats:italic>versus<\/jats:italic>the no asthma group (p&lt;0.05). Despite similar body size, oscillometry measurements demonstrated elevated<jats:italic>R<\/jats:italic><jats:sub>5\u201320<\/jats:sub>(difference between resistance at 5 and 20\u2005Hz) in the no asthma and asthma normal spirometry groups (0.19\u00b10.12; 0.23\u00b10.13\u2005kPa\/(L\u00b7s<jats:sup>\u22121<\/jats:sup>), p&lt;0.05) but to a lesser degree than the asthma obstructed spirometry group (0.34\u00b10.20\u2005kPa\/(L\u00b7s<jats:sup>\u22121<\/jats:sup>), p&lt;0.05). Differences between groups persisted post-bronchodilator (p&lt;0.05). Following voluntary inflation to predicted FRC,<jats:italic>R<\/jats:italic><jats:sub>5\u201320<\/jats:sub>in the no asthma and asthma normal spirometry groups fell to similar values, indicating a reversible process (0.11\u00b10.07; 0.12\u00b10.08\u2005kPa\/(L\u00b7s<jats:sup>\u22121<\/jats:sup>), p=NS). Persistently elevated<jats:italic>R<\/jats:italic><jats:sub>5\u201320<\/jats:sub>was seen in the asthma obstructed spirometry group, suggesting chronic inflammation and\/or remodelling (0.17\u00b10.11\u2005kPa\/(L\u00b7s<jats:sup>\u22121<\/jats:sup>), p&lt;0.05).<\/jats:p><jats:p>Thus, small airway abnormalities of greater magnitude than observations in healthy obese people may be an early marker of asthma in obese subjects with self-reported disease despite normal airflow. Increased metabolic comorbidities in these subjects may have provided a milieu that impacted airway function.<\/jats:p>","DOI":"10.1183\/23120541.00371-2019","type":"journal-article","created":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T14:45:26Z","timestamp":1595256326000},"page":"00371-2019","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Small airway function in obese individuals with self-reported asthma"],"prefix":"10.1183","volume":"6","author":[{"given":"Beno W.","family":"Oppenheimer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta M.","family":"Goldring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Israa","family":"Soghier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish","family":"Parikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth I.","family":"Berger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2020,7,20]]},"reference":[{"key":"2024101707553823000_6.2.00371-2019.1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.24678"},{"key":"2024101707553823000_6.2.00371-2019.2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201203-0573OC"},{"key":"2024101707553823000_6.2.00371-2019.3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2012.04040.x"},{"key":"2024101707553823000_6.2.00371-2019.4","doi-asserted-by":"publisher","DOI":"10.1081\/JAS-120037651"},{"key":"2024101707553823000_6.2.00371-2019.5","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200903-013ST"},{"key":"2024101707553823000_6.2.00371-2019.6","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200906-0896OC"},{"key":"2024101707553823000_6.2.00371-2019.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2009.05.002"},{"key":"2024101707553823000_6.2.00371-2019.8","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.1.ats11-99"},{"key":"2024101707553823000_6.2.00371-2019.9","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00083.2009"},{"key":"2024101707553823000_6.2.00371-2019.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2009.01.006"},{"key":"2024101707553823000_6.2.00371-2019.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.01.064"},{"key":"2024101707553823000_6.2.00371-2019.12","doi-asserted-by":"crossref","first-page":"e88015","DOI":"10.1371\/journal.pone.0088015","article-title":"Airway dysfunction in obesity: response to voluntary restoration of end expiratory lung volume","volume":"9","author":"Oppenheimer","year":"2014","journal-title":"PLoS ONE"},{"key":"2024101707553823000_6.2.00371-2019.13","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00694.2009"},{"key":"2024101707553823000_6.2.00371-2019.14","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00104504"},{"key":"2024101707553823000_6.2.00371-2019.15","doi-asserted-by":"publisher","DOI":"10.1378\/chest.130.3.827"},{"key":"2024101707553823000_6.2.00371-2019.16","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1164\/arrd.1983.128.3.501","article-title":"Effects of obesity on respiratory function","volume":"128","author":"Ray","year":"1983","journal-title":"Am Rev Respir Dis"},{"key":"2024101707553823000_6.2.00371-2019.17","doi-asserted-by":"publisher","DOI":"10.1378\/chest.103.5.1470"},{"key":"2024101707553823000_6.2.00371-2019.18","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.soard.2011.08.004","article-title":"Distal airway dysfunction in obese subjects corrects after bariatric surgery","volume":"8","author":"Oppenheimer","year":"2012","journal-title":"Surg Obes Relat Dis"},{"key":"2024101707553823000_6.2.00371-2019.19","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201401-0178OC"},{"key":"2024101707553823000_6.2.00371-2019.20","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034805"},{"key":"2024101707553823000_6.2.00371-2019.21","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00035005"},{"key":"2024101707553823000_6.2.00371-2019.22","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1983.127.6.725"},{"key":"2024101707553823000_6.2.00371-2019.23","first-page":"457","article-title":"Normal values at median altitudes and the prediction of normal results","volume":"79","author":"Goldman","year":"1959","journal-title":"Am Rev Tuberc"},{"key":"2024101707553823000_6.2.00371-2019.24","first-page":"893","article-title":"Reference values for pulmonary tissue volume, membrane diffusing capacity, and pulmonary capillary blood volume","volume":"18","author":"Crapo","year":"1982","journal-title":"Bull Eur Physiopathol Respir"},{"key":"2024101707553823000_6.2.00371-2019.25","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2005.05.026"},{"key":"2024101707553823000_6.2.00371-2019.26","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-0913"},{"key":"2024101707553823000_6.2.00371-2019.27","doi-asserted-by":"publisher","DOI":"10.1378\/chest.81.5.586"},{"key":"2024101707553823000_6.2.00371-2019.28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/08942680152007855","article-title":"Impulse oscillometry in healthy nonsmokers and asymptomatic smokers: effects of bronchial challenge with methacholine","volume":"14","author":"Kohlhaufl","year":"2001","journal-title":"J Aerosol Med"},{"key":"2024101707553823000_6.2.00371-2019.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2010.05.013"},{"key":"2024101707553823000_6.2.00371-2019.30","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00126212"},{"key":"2024101707553823000_6.2.00371-2019.31","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.162.13.1477"},{"key":"2024101707553823000_6.2.00371-2019.32","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1080\/17476348.2018.1506331","article-title":"The effect of obesity on lung function","volume":"12","author":"Dixon","year":"2018","journal-title":"Expert Rev Respir Med"},{"key":"2024101707553823000_6.2.00371-2019.33","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/S2213-2600(19)30049-9","article-title":"Exploring the relevance and extent of small airways dysfunction in asthma (ATLANTIS): baseline data from a prospective cohort study","volume":"7","author":"Postma","year":"2019","journal-title":"Lancet Respir Med"},{"key":"2024101707553823000_6.2.00371-2019.34","first-page":"347","article-title":"Impedance of intrathoracic airway models during low-frequency periodic flow","volume":"47","author":"Fredberg","year":"1979","journal-title":"J Appl Physiol Respir Environ Exerc Physiol"},{"key":"2024101707553823000_6.2.00371-2019.35","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2005.04.021"},{"key":"2024101707553823000_6.2.00371-2019.36","doi-asserted-by":"crossref","first-page":"e0152769","DOI":"10.1371\/journal.pone.0152769","article-title":"Pulmonary vascular congestion: a mechanism for distal lung unit dysfunction in obesity","volume":"11","author":"Oppenheimer","year":"2016","journal-title":"PLoS ONE"},{"key":"2024101707553823000_6.2.00371-2019.37","doi-asserted-by":"crossref","first-page":"818","DOI":"10.3109\/02770903.2011.613508","article-title":"Airway responsiveness measured by forced oscillation technique in severely obese patients, before and after bariatric surgery","volume":"48","author":"Zerah-Lancner","year":"2011","journal-title":"J Asthma"},{"key":"2024101707553823000_6.2.00371-2019.38","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.jaci.2014.09.016","article-title":"Peripheral airways dysfunction in obesity reflects increased bronchomotor tone","volume":"135","author":"Desai","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"2024101707553823000_6.2.00371-2019.39","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01155.2010"},{"key":"2024101707553823000_6.2.00371-2019.40","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200711-1738OC"},{"key":"2024101707553823000_6.2.00371-2019.41","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00043-2015"},{"key":"2024101707553823000_6.2.00371-2019.42","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200711-1754OC"},{"key":"2024101707553823000_6.2.00371-2019.43","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2007.082784"},{"key":"2024101707553823000_6.2.00371-2019.44","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2019-213678"}],"container-title":["ERJ Open Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/23120541.00371-2019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T05:03:36Z","timestamp":1740373416000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/23120541.00371-2019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":44,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,7,20]]},"published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1183\/23120541.00371-2019"],"URL":"https:\/\/doi.org\/10.1183\/23120541.00371-2019","relation":{},"ISSN":["2312-0541"],"issn-type":[{"value":"2312-0541","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4]]}}}