{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T22:55:48Z","timestamp":1789253748840,"version":"build-2803163510"},"reference-count":46,"publisher":"European Respiratory Society (ERS)","issue":"2","license":[{"start":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T00:00:00Z","timestamp":1675296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","award":["20180584, 20180567, 20210529"],"award-info":[{"award-number":["20180584, 20180567, 20210529"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["ERJ Open Res"],"accepted":{"date-parts":[[2022,12,11]]},"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Coexisting obstructive sleep apnoea (OSA) in patients with COPD, defined as overlap syndrome (OVS), is prevalent and underdiagnosed. Routine assessment of OSA is not common practice in COPD care. Our study assessed the clinical impact of sleep assessment by peripheral arterial tonometry (PAT) in COPD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>105 COPD patients (mean age 68.1\u00b19\u2005years, body mass index (BMI) 28.3\u00b16.0\u2005kg\u00b7m<jats:sup>\u22122<\/jats:sup>, 44% males, Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages I to IV in 2%, 40%, 42% and 16%, respectively) underwent assessment at an outpatient COPD clinic including anthropometrics, arterial blood gas (ABG) and spirometry in this clinical cohort study. PAT-based sleep studies were performed. Predictors of OVS and ABG were determined. Rapid eye movement (REM) sleep-related OSA (REM-OSA) was analysed in OVS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>49 COPD patients (47%) suffered from moderate to severe OSA (OVS group, mean apnoea\u2013hypopnoea index 30.8\u00b118\u2005events\u00b7h<jats:sup>\u22121<\/jats:sup>, REM-oxygen desaturation index (REM-ODI) 26.9\u00b117\u2005events\u00b7h<jats:sup>\u22121<\/jats:sup>). OVS was more prevalent in males compared to females (59% and 37%, p=0.029, respectively). Age (70.1\u00b18<jats:italic>versus<\/jats:italic>66.3\u00b110\u2005years), BMI (30.0\u00b16<jats:italic>versus<\/jats:italic>26.4\u00b17\u2005kg\u00b7m<jats:sup>\u22122<\/jats:sup>) and hypertension prevalence (71%<jats:italic>versus<\/jats:italic>45%) were elevated (all p&lt;0.03, respectively), while deep sleep (12.7\u00b17% and 15.4\u00b16%, p=0.029) and mean overnight oxygenation (90.6\u00b13% and 92.3\u00b12%, p=0.003) were lower in OVS compared to COPD alone. REM-ODI was independently associated with daytime arterial carbon dioxide tension (<jats:italic>P<\/jats:italic><jats:sub>aCO<jats:sub>2<\/jats:sub><\/jats:sub>) (\u03b2=0.022, p&lt;0.001). REM-OSA was associated with an elevated prevalence of atrial fibrillation compared to no REM-OSA (25% and 3%, p=0.022).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>OVS was highly prevalent, specifically in obese males. REM-related OSA showed strong association with elevated daytime<jats:italic>P<\/jats:italic><jats:sub>aCO<jats:sub>2<\/jats:sub><\/jats:sub>and prevalent cardiovascular disease. PAT was feasible for sleep assessment in COPD.<\/jats:p><\/jats:sec>","DOI":"10.1183\/23120541.00458-2022","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T17:20:51Z","timestamp":1675358451000},"page":"00458-2022","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Clinical impact of routine sleep assessment by peripheral arterial tonometry in patients with COPD"],"prefix":"10.1183","volume":"9","author":[{"given":"Daniel","family":"Hansson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4387-4096","authenticated-orcid":false,"given":"Lowie E.G.W.","family":"Vanfleteren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Andelid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2057-8558","authenticated-orcid":false,"given":"Ding","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Hedner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7405-1682","authenticated-orcid":false,"given":"Ludger","family":"Grote","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2023,2,2]]},"reference":[{"key":"2024101711482727000_9.2.00458-2022.1","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0272-5231(21)00402-0","article-title":"Sleep in chronic obstructive lung disease","volume":"6","author":"Flenley","year":"1985","journal-title":"Clin Chest Med"},{"key":"2024101711482727000_9.2.00458-2022.2","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1016\/j.chest.2017.04.160","article-title":"COPD-OSA overlap syndrome: evolving evidence regarding epidemiology, clinical consequences, and management","volume":"152","author":"McNicholas","year":"2017","journal-title":"Chest"},{"key":"2024101711482727000_9.2.00458-2022.3","doi-asserted-by":"crossref","first-page":"259","DOI":"10.5664\/jcsm.4540","article-title":"Sleep disorders in chronic obstructive pulmonary disease: etiology, impact, and management","volume":"11","author":"Budhiraja","year":"2015","journal-title":"J Clin Sleep Med"},{"key":"2024101711482727000_9.2.00458-2022.4","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1513\/AnnalsATS.201506-379LE","article-title":"High prevalence of obstructive sleep apnea in patients with moderate to severe chronic obstructive pulmonary disease","volume":"12","author":"Soler","year":"2015","journal-title":"Ann Am Thorac Soc"},{"key":"2024101711482727000_9.2.00458-2022.5","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-14-132"},{"key":"2024101711482727000_9.2.00458-2022.6","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.sleep.2021.05.031","article-title":"Investigation into the association between obstructive sleep apnea and incidence of all-type cancers: a systematic review and meta-analysis","volume":"88","author":"Cheng","year":"2021","journal-title":"Sleep Med"},{"key":"2024101711482727000_9.2.00458-2022.7","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.jacc.2021.05.048","article-title":"Sleep disordered breathing and cardiovascular disease: JACC state-of-the-art review","volume":"78","author":"Cowie","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"2024101711482727000_9.2.00458-2022.8","first-page":"454","article-title":"Chronic obstructive pulmonary disease and lung cancer: a review for clinicians","volume":"9","author":"Criner","year":"2022","journal-title":"Chronic Obstr Pulm Dis"},{"key":"2024101711482727000_9.2.00458-2022.9","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1164\/rccm.201604-0690SO","article-title":"Chronic obstructive pulmonary disease and cardiac diseases. 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