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The aims of the present study were to investigate the association between childhood lung function and onset and persistence of asthma during adolescence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the population-based BAMSE (Sweden), PIAMA (Netherlands) and MAAS (UK) birth cohorts, we analysed the association of forced expiratory volume in 1\u2005s (FEV<jats:sub>1<\/jats:sub>), forced vital capacity (FVC), FEV<jats:sub>1<\/jats:sub>\/FVC and forced expiratory volume at 75% of FVC at age 8\u2005years with asthma onset and persistence in adolescence (age 12\u201316\u2005years) using cohort-specific logistic regression analysis followed by meta-analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the BAMSE, PIAMA and MAAS cohorts, asthma incidence in adolescence was 6.1% (112\/1824), 3.4% (36\/1050) and 5.0% (39\/779), respectively. Persistent asthma from childhood to adolescence was observed in 8.2%, 6.4% and 7.7% of all subjects within the respective cohorts. A higher FEV<jats:sub>1<\/jats:sub>% predicted and FEV<jats:sub>1<\/jats:sub>\/FVC at age 8\u2005years was associated with a lower odds for adolescent-onset asthma: OR 0.98 (95% CI 0.97\u20131.00) and 0.97 (0.94\u20130.99). These associations remained significant also when restricting the analyses to subjects with no wheezing or asthma treatment in childhood. A higher FEV<jats:sub>1<\/jats:sub>\/FVC at age 8\u2005years was associated with a lower odds for asthma persistence in adolescence (0.96 (0.93\u20130.99)). Sex by lung function interaction analysis was not significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A higher lung function at school age was associated with a lower risk of adolescent-onset asthma, predominantly in males. This indicates that a lower lung function in childhood may precede and or potentially contribute to asthma incidence and persistence.<\/jats:p><\/jats:sec>","DOI":"10.1183\/23120541.00469-2024","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T16:27:55Z","timestamp":1724344075000},"page":"00469-2024","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Childhood lung function is associated with adolescent-onset and persistent asthma"],"prefix":"10.1183","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8285-0492","authenticated-orcid":false,"given":"Hans Jacob 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