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In a precedent trial (HYPNOBPCO_1,<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"isrctn\" xlink:href=\"10029862\">ISRCTN10029862<\/jats:ext-link>), administering a single hypnosis session was linked to reduced anxiety and improved breathing mechanics in intermediate and advanced COPD patients. However, whether hypnosis could improve self-management of anxiety and dyspnoea in COPD during pulmonary rehabilitation is yet to be investigated.<\/jats:p><jats:p>This is the protocol for HYPNOBPCO_2, a 2-arm, cluster-randomised, statistician-blinded superiority monocentre trial (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT04868357\">NCT04868357<\/jats:ext-link>). Its aim is to assess the efficacy of hypnosis as a tool to manage anxiety and dyspnoea during a pulmonary rehabilitation programme (PRP). Clusters of COPD patients eligible for the conventional hospital-based PRP at the Centre Hospitalier de Bligny (CHB) will be randomised and evenly allocated into two parallel arms: \u201cHypnosis\u201d (treatment) and \u201cRelaxation\u201d (active control). \u201cHypnosis\u201d will consist of the CHB's conventional 4-week group PRP, supplemented by two educational sessions for teaching self-hypnosis. \u201cRelaxation\u201d will be identical, except standard relaxation exercises will be taught instead. Primary end-point will consist of assessing weekly changes in anxiety throughout the PRP, additional to total anxiety change after treatment completion. Anxiety will be determined by the six-item version of the State-Trait Anxiety Inventory (STAI-6). Secondary outcomes will include change in the 6-min walk test and the COPD assessment test (CAT). Further follow-up outcomes will include CAT and STAI-6 retests, re-hospitalisation rate, action plan use and persistence in self-hypnosis use, throughout the 12\u2005weeks ensuing PRP completion.<\/jats:p>","DOI":"10.1183\/23120541.00565-2021","type":"journal-article","created":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T17:10:29Z","timestamp":1642698629000},"page":"00565-2021","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Hypnosis for the management of COPD-related anxiety and dyspnoea in pulmonary rehabilitation: rationale and design for a cluster-randomised, active-control trial (HYPNOBPCO_2)"],"prefix":"10.1183","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1663-1881","authenticated-orcid":false,"given":"Hern\u00e1n","family":"Anll\u00f3,","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2108-5029","authenticated-orcid":false,"given":"Bertrand","family":"Herer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agathe","family":"Deligni\u00e8res","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelina","family":"Ghergan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolaine","family":"Bocahu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Segundo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Moulin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Larue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2022,1,20]]},"reference":[{"key":"2024101711272549000_8.1.00565-2021.1","first-page":"1615","article-title":"Anxiety and depression: important psychological comorbidities of COPD","volume":"6","author":"Pumar","year":"2014","journal-title":"J Thorac Dis"},{"key":"2024101711272549000_8.1.00565-2021.2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00193213"},{"key":"2024101711272549000_8.1.00565-2021.3","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/0163-8343(92)90022-3","article-title":"Dyspnea, anxiety, and depression in chronic respiratory impairment","volume":"14","author":"Kellner","year":"1992","journal-title":"Gen Hosp Psychiatry"},{"key":"2024101711272549000_8.1.00565-2021.4","doi-asserted-by":"publisher","DOI":"10.1177\/0269216313480255"},{"key":"2024101711272549000_8.1.00565-2021.5","doi-asserted-by":"crossref","first-page":"297","DOI":"10.2147\/NDT.S79354","article-title":"Strategies to improve anxiety and depression in patients with COPD: a mental health perspective","volume":"12","author":"Tselebis","year":"2016","journal-title":"Neuropsychiatr Dis Treat"},{"key":"2024101711272549000_8.1.00565-2021.6","unstructured":"Global Initiative for Chronic Obstructive Lung Disease . 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