{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T22:27:48Z","timestamp":1789424868413,"version":"build-2803163510"},"reference-count":25,"publisher":"European Respiratory Society (ERS)","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001491","name":"Belgian American Educational Foundation","doi-asserted-by":"publisher","award":["Postdoctoral fellowship"],"award-info":[{"award-number":["Postdoctoral fellowship"]}],"id":[{"id":"10.13039\/100001491","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["K23ES026204, R01ES031252, P30ES000002"],"award-info":[{"award-number":["K23ES026204, R01ES031252, P30ES000002"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["F32 HL143819"],"award-info":[{"award-number":["F32 HL143819"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001589","name":"Environmental Protection Agency","doi-asserted-by":"publisher","award":["RD-835872"],"award-info":[{"award-number":["RD-835872"]}],"id":[{"id":"10.13039\/501100001589","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004385","name":"Universiteit Gent","doi-asserted-by":"publisher","award":["Strategic International partnership grant with Har"],"award-info":[{"award-number":["Strategic International partnership grant with Har"]}],"id":[{"id":"10.13039\/501100004385","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["ERJ Open Res"],"accepted":{"date-parts":[[2021,12,28]]},"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec><jats:title>Rationale<\/jats:title><jats:p>Chronic obstructive pulmonary disease (COPD) patients often report aggravated symptoms due to heat and cold, but few studies have formally evaluated this.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>We followed 30 Boston-based former smokers with COPD for four non-consecutive 30-day periods over 12\u2005months. Personal and outdoor temperature exposure were measured using portable and Boston-area outdoor stationary monitors. Participants recorded daily morning lung function measurements as well as any worsening breathing (breathlessness, chest tightness, wheeze) and bronchitis symptoms (cough, sputum colour and amount) compared to baseline. Using linear and generalised linear mixed-effects models, we assessed associations between personal and outdoor temperature exposure (1\u20133-day moving averages) and lung function and symptoms, adjusting for humidity, smoking pack-years and demographics. We also stratified by warm and cold season.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Participants were on average 71.1\u00b18.4\u2005years old, with 54.4\u00b130.7\u2005pack-years of smoking. Each 5\u00b0C increase in personal temperature exposure was associated with 1.85 (95% CI 0.99\u20133.48) higher odds of worsening breathing symptoms. In the warm season, each 5\u00b0C increase in personal and outdoor temperature exposure was associated with 3.20 (95% CI 1.05\u20139.72) and 2.22 (95% CI 1.41\u20133.48) higher odds of worsening breathing symptoms, respectively. Each 5\u00b0C decrease in outdoor temperature was associated with 1.25 (95% CI 1.04\u20131.51) higher odds of worsening bronchitis symptoms. There were no associations between temperature and lung function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings suggest that higher temperature, including outdoor exposure during the warm season and personal temperature exposure year-round, may worsen dyspnoea, while colder outdoor temperature may trigger cough and phlegm symptoms among COPD patients.<\/jats:p><\/jats:sec>","DOI":"10.1183\/23120541.00574-2021","type":"journal-article","created":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T18:05:16Z","timestamp":1643911516000},"page":"00574-2021","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":31,"title":["The impact of personal and outdoor temperature exposure during cold and warm seasons on lung function and respiratory symptoms in COPD"],"prefix":"10.1183","volume":"8","author":[{"given":"Charlotte","family":"Scheerens","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Nurhussien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amro","family":"Aglan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3215-4808","authenticated-orcid":false,"given":"Andrew J.","family":"Synn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent A.","family":"Coull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petros","family":"Koutrakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2538-391X","authenticated-orcid":false,"given":"Mary B.","family":"Rice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2022,2,3]]},"reference":[{"key":"2024101711275258000_8.1.00574-2021.1","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/S2213-2600(17)30293-X","article-title":"Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990\u20132015: a systematic analysis for the Global Burden of Disease Study 2015","volume":"5","author":"Soriano","year":"2017","journal-title":"Lancet Respir Med"},{"key":"2024101711275258000_8.1.00574-2021.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2008.07.006"},{"key":"2024101711275258000_8.1.00574-2021.3","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.57.10.847"},{"key":"2024101711275258000_8.1.00574-2021.4","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-2384"},{"key":"2024101711275258000_8.1.00574-2021.5","doi-asserted-by":"crossref","first-page":"372","DOI":"10.3109\/15412555.2015.1089846","article-title":"The effects of air pollution and temperature on COPD","volume":"13","author":"Hansel","year":"2016","journal-title":"COPD"},{"key":"2024101711275258000_8.1.00574-2021.6","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1513\/AnnalsATS.201605-329OC","article-title":"Respiratory effects of indoor heat and the interaction with air pollution in chronic obstructive pulmonary disease","volume":"13","author":"McCormack","year":"2016","journal-title":"Ann Am Thorac Soc"},{"key":"2024101711275258000_8.1.00574-2021.7","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01501-2016"},{"key":"2024101711275258000_8.1.00574-2021.8","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201211-1969OC"},{"key":"2024101711275258000_8.1.00574-2021.9","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00612-2018"},{"key":"2024101711275258000_8.1.00574-2021.10","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00010126"},{"key":"2024101711275258000_8.1.00574-2021.11","doi-asserted-by":"crossref","first-page":"2003432","DOI":"10.1183\/13993003.03432-2020","article-title":"Personal exposure to air pollution and respiratory health of COPD patients in London","volume":"4","author":"Evangelopoulos","year":"2021","journal-title":"Eur Respir J"},{"key":"2024101711275258000_8.1.00574-2021.12","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00035205"},{"key":"2024101711275258000_8.1.00574-2021.13","doi-asserted-by":"crossref","unstructured":"Nurhussien L , Kang C-M , Koutrakis P , et al. Air pollution exposure and daily lung function in COPD: effect modification by eosinophilia. 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