{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T07:17:25Z","timestamp":1777792645253,"version":"3.51.4"},"reference-count":39,"publisher":"European Respiratory Society (ERS)","issue":"1","license":[{"start":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T00:00:00Z","timestamp":1724976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01AG029824 and U19AG062682"],"award-info":[{"award-number":["U01AG029824 and U19AG062682"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1028368"],"award-info":[{"award-number":["1028368"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["334047 and 1127060"],"award-info":[{"award-number":["334047 and 1127060"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["ERJ Open Res"],"accepted":{"date-parts":[[2024,8,3]]},"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec><jats:title>Importance<\/jats:title><jats:p>Obstructive sleep apnoea (OSA) may increase the risk of dementia; however, studies have reported variable findings. We investigated if undiagnosed OSA in healthy older adults is associated with cognitive decline, and whether low-dose aspirin could attenuate this.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was conducted as a substudy of the ASPirin in Reducing Events in the Elderly study. Participants were aged 70\u2005years and above, free of dementia, cardiovascular disease and known OSA. A limited channel home sleep study calculated the oxygen desaturation index. Participants were randomised to daily aspirin 100\u2005mg or placebo<jats:bold>.<\/jats:bold>Outcomes were the association of OSA, and the interaction of aspirin with OSA, with change in the Modified Mini-Mental State examination (3MS), a test of global cognition, over 3\u2005years. Secondary outcomes were changes in domain-specific cognitive tests. Analyses were adjusted for relevant demographic, lifestyle and cardiometabolic factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mild OSA, detected in 630 (49.0%) participants, and moderate\/severe OSA, detected in 405 (31.5%) participants, were associated with lower 3MS scores over 3\u2005years (mild OSA: \u03b2<jats:bold>\u2212<\/jats:bold>0.58, 95% CI \u22121.15 to \u22120.00, p=0.049; moderate\/severe OSA: \u03b2 \u22120.69, 95% CI \u22121.32 to \u22120.05, p=0.035), compared to the 250 (19.5%) participants without OSA. No associations of OSA with decline in domain-specific cognitive tests were observed. Interaction terms were not significant for the effects of aspirin with OSA on change in any cognitive test score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>OSA was associated with a small decline in global cognition over 3\u2005years in this healthy older cohort. This decline was not attenuated by aspirin.<\/jats:p><\/jats:sec>","DOI":"10.1183\/23120541.00581-2024","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T13:30:11Z","timestamp":1725024611000},"page":"00581-2024","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Sleep apnoea, cognition and aspirin's effects in healthy older people: an ASPREE substudy"],"prefix":"10.1183","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1439-3373","authenticated-orcid":false,"given":"Stephanie A.","family":"Ward","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robyn L.","family":"Woods","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew T.","family":"Naughton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rory","family":"Wolfe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danijela","family":"Gasevic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Garun S.","family":"Hamilton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter P.","family":"Abhayaratna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9380-6075","authenticated-orcid":false,"given":"Katherine","family":"Webb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fergal J.","family":"O'Donoghue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nigel","family":"Stocks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth E.","family":"Trevaks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharyn M.","family":"Fitzgerald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne G.","family":"Orchard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher M.","family":"Reid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elsdon","family":"Storey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2024,8,30]]},"reference":[{"key":"2025030304054082000_11.1.00581-2024.1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01649-2021"},{"key":"2025030304054082000_11.1.00581-2024.2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2017.2180"},{"key":"2025030304054082000_11.1.00581-2024.3","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s11065-017-9344-6","article-title":"Is obstructive sleep apnoea related to neuropsychological function in healthy older adults? 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