{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T04:40:58Z","timestamp":1781498458397,"version":"3.54.1"},"reference-count":60,"publisher":"European Respiratory Society (ERS)","issue":"2","license":[{"start":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T00:00:00Z","timestamp":1674691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017647","name":"ResMed","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017647","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["ERJ Open Res"],"accepted":{"date-parts":[[2023,1,9]]},"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Although adaptive servo-ventilation (ASV) effectively supresses central sleep apnoea (CSA), little is known about real-world indications of ASV therapy and its effects on quality of life (QoL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This report details the design, baseline characteristics, indications for ASV and symptom burden in patients enrolled in the Registry on the Treatment of Central and Complex Sleep-Disordered Breathing with Adaptive Servo-Ventilation (READ-ASV). This multicentre, European, non-interventional trial enrolled participants prescribed ASV in clinical practice between September 2017 and March 2021. An expert review board assigned participants to ASV indications using a guideline-based semi-automated algorithm. The primary end-point was change in disease-specific QoL based on the Functional Outcomes of Sleep Questionnaire (FOSQ) from baseline to 12-month follow-up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The registry population includes 801 participants (age 67\u00b112\u2005years, 14% female). Indications for ASV were treatment-emergent or persistent CSA (56%), CSA in cardiovascular disease (31%), unclassified CSA (2%), coexisting obstructive sleep apnoea and CSA (4%), obstructive sleep apnoea (3%), CSA in stroke (2%) and opioid-induced CSA (1%). Baseline mean apnoea\u00ad\u2013hypopnoea index was 48\u00b123 events\u00b7h<jats:sup>\u22121<\/jats:sup>(\u226530 events\u00b7h<jats:sup>\u22121<\/jats:sup>in 78%), FOSQ score was 16.7\u00b13.0 (&lt;17.9 in 54%) and Epworth Sleepiness Scale (ESS) score was 8.8\u00b14.9 (&gt;10 in 34%); 62% of patients were symptomatic (FOSQ score &lt;17.9 or ESS score &gt;10).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The most common indications for ASV were treatment-emergent or persistent CSA or CSA in cardiovascular disease (excluding systolic heart failure). Patients using ASV in clinical practice had severe sleep-disordered breathing and were often symptomatic. One-year follow-up will provide data on the effects of ASV on QoL, respiratory parameters and clinical outcomes in these patients.<\/jats:p><\/jats:sec>","DOI":"10.1183\/23120541.00618-2022","type":"journal-article","created":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T16:59:37Z","timestamp":1674752377000},"page":"00618-2022","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Registry on the Treatment of Central and Complex Sleep-Disordered Breathing with Adaptive Servo-Ventilation (READ-ASV): protocol and cohort profile"],"prefix":"10.1183","volume":"9","author":[{"given":"Michael","family":"Arzt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Munt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"P\u00e9pin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Heinzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphaela","family":"K\u00fcbeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"von Hehn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Ehrsam-Tosi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Benjafield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Woehrle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2023,1,26]]},"reference":[{"key":"2024101711510658000_9.2.00618-2022.1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.3.9911064"},{"key":"2024101711510658000_9.2.00618-2022.2","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/S2213-2600(15)00043-0","article-title":"Prevalence of sleep-disordered breathing in the general population: the HypnoLaus study","volume":"3","author":"Heinzer","year":"2015","journal-title":"Lancet Respir Med"},{"key":"2024101711510658000_9.2.00618-2022.3","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2109080"},{"key":"2024101711510658000_9.2.00618-2022.4","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S2213-2600(19)30198-5","article-title":"Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis","volume":"7","author":"Benjafield","year":"2019","journal-title":"Lancet Respir Med"},{"key":"2024101711510658000_9.2.00618-2022.5","doi-asserted-by":"crossref","first-page":"4100","DOI":"10.1002\/ehf2.14027","article-title":"Prevalence and predictors of sleep-disordered breathing in chronic heart failure: the SchlaHF-XT registry","volume":"9","author":"Arzt","year":"2022","journal-title":"ESC Heart Fail"},{"key":"2024101711510658000_9.2.00618-2022.6","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1513\/AnnalsATS.202006-696FR","article-title":"Excessive daytime sleepiness in obstructive sleep apnea. Mechanisms and clinical management","volume":"18","author":"Lal","year":"2021","journal-title":"Ann Am Thorac Soc"},{"key":"2024101711510658000_9.2.00618-2022.7","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S1474-4422(21)00321-5","article-title":"Sleep apnoea and ischaemic stroke: current knowledge and future directions","volume":"21","author":"Baillieul","year":"2022","journal-title":"Lancet Neurol"},{"key":"2024101711510658000_9.2.00618-2022.8","first-page":"e8241","article-title":"Obstructive sleep apnea and hypertension: a review of the relationship and pathogenic association","volume":"12","author":"Bangash","year":"2020","journal-title":"Cureus"},{"key":"2024101711510658000_9.2.00618-2022.9","doi-asserted-by":"publisher","DOI":"10.1111\/imj.12108"},{"key":"2024101711510658000_9.2.00618-2022.10","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.16.1709"},{"key":"2024101711510658000_9.2.00618-2022.11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005113421901"},{"key":"2024101711510658000_9.2.00618-2022.12","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh261"},{"key":"2024101711510658000_9.2.00618-2022.13","doi-asserted-by":"publisher","DOI":"10.1016\/J.CHEST.2017.05.009"},{"key":"2024101711510658000_9.2.00618-2022.14","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/24.1.96"},{"key":"2024101711510658000_9.2.00618-2022.15","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1007\/s11325-021-02323-1","article-title":"Association between obstructive sleep apnea and health-related quality of life in untreated adults: a systematic review","volume":"25","author":"Pauletto","year":"2021","journal-title":"Sleep Breath"},{"key":"2024101711510658000_9.2.00618-2022.16","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.5664\/jcsm.9436","article-title":"Prevalence of sleepiness and associations with quality of life in patients with sleep apnea in an online cohort","volume":"17","author":"Wanberg","year":"2021","journal-title":"J Clin Sleep Med"},{"key":"2024101711510658000_9.2.00618-2022.17","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06.2287"},{"key":"2024101711510658000_9.2.00618-2022.18","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-1715"},{"key":"2024101711510658000_9.2.00618-2022.19","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.4.9908114"},{"key":"2024101711510658000_9.2.00618-2022.20","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-0815"},{"key":"2024101711510658000_9.2.00618-2022.21","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s11325-019-01882-8","article-title":"Use of adaptive servo ventilation therapy as treatment of sleep-disordered breathing and heart failure: a systematic review and meta-analysis","volume":"24","author":"Hernandez","year":"2020","journal-title":"Sleep Breath"},{"key":"2024101711510658000_9.2.00618-2022.22","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00083312"},{"key":"2024101711510658000_9.2.00618-2022.23","first-page":"Cd012803","article-title":"Positive airway pressure therapy for the treatment of central sleep apnoea associated with heart failure","volume":"12","author":"Yamamoto","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"key":"2024101711510658000_9.2.00618-2022.24","doi-asserted-by":"crossref","first-page":"757","DOI":"10.5664\/jcsm.5812","article-title":"Updated adaptive servo-ventilation recommendations for the 2012 AASM Guideline: \u201cthe treatment of central sleep apnea syndromes in adults: practice parameters with an evidence-based literature review and meta-analyses\u201d","volume":"12","author":"Aurora","year":"2016","journal-title":"J Clin Sleep Med"},{"key":"2024101711510658000_9.2.00618-2022.25","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506459"},{"key":"2024101711510658000_9.2.00618-2022.26","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000152"},{"key":"2024101711510658000_9.2.00618-2022.27","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1253\/circj.72.489","article-title":"Impending epidemic: future projection of heart failure in Japan to the year 2055","volume":"72","author":"Okura","year":"2008","journal-title":"Circ J"},{"key":"2024101711510658000_9.2.00618-2022.28","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2021-217205"},{"key":"2024101711510658000_9.2.00618-2022.29","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-038403"},{"key":"2024101711510658000_9.2.00618-2022.30","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00959-2016"},{"key":"2024101711510658000_9.2.00618-2022.31","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1007\/s11818-017-0136-2","article-title":"German S3 guideline nonrestorative sleep\/sleep disorders, chapter \u201csleep-related breathing disorders in adults,\u201d short version","volume":"21","author":"Mayer","year":"2017","journal-title":"Somnologie"},{"key":"2024101711510658000_9.2.00618-2022.32","doi-asserted-by":"publisher","DOI":"10.1080\/17476348.2019.1604226"},{"key":"2024101711510658000_9.2.00618-2022.33","doi-asserted-by":"crossref","first-page":"17","DOI":"10.5665\/sleep.1580","article-title":"The treatment of central sleep apnea syndromes in adults: practice parameters with an evidence-based literature review and meta-analyses","volume":"35","author":"Aurora","year":"2012","journal-title":"Sleep"},{"key":"2024101711510658000_9.2.00618-2022.34","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1007\/s11818-017-0136-2","article-title":"German S3 guideline nonrestorative sleep\/sleep disorders, chapter \u201cSleep-related breathing disorders in adults,\u201d short version: German Sleep Society (Deutsche Gesellschaft f\u00fcr Schlafforschung und Schlafmedizin, DGSM)","volume":"21","author":"Mayer","year":"2017","journal-title":"Somnologie"},{"key":"2024101711510658000_9.2.00618-2022.35","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.6576"},{"key":"2024101711510658000_9.2.00618-2022.36","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.5176"},{"key":"2024101711510658000_9.2.00618-2022.37","first-page":"835","article-title":"An instrument to measure functional status outcomes for disorders of excessive sleepiness","volume":"20","author":"Weaver","year":"1997","journal-title":"Sleep"},{"key":"2024101711510658000_9.2.00618-2022.38","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.6506"},{"key":"2024101711510658000_9.2.00618-2022.39","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/30.6.711"},{"key":"2024101711510658000_9.2.00618-2022.40","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1164\/rccm.201704-0672LE","article-title":"The Epworth Sleepiness Scale: minimum clinically important difference in obstructive sleep apnea","volume":"197","author":"Patel","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"key":"2024101711510658000_9.2.00618-2022.41","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(89)90047-4"},{"key":"2024101711510658000_9.2.00618-2022.42","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2010.535"},{"key":"2024101711510658000_9.2.00618-2022.43","unstructured":"EuroQol . EQ-5D. https:\/\/euroqol.org\/eq-5d-instruments\/. Date last accessed: 6 October 2022."},{"key":"2024101711510658000_9.2.00618-2022.44","unstructured":"EuroQol . EQ-5D-3L User Guide. https:\/\/euroqol.org\/publications\/user-guides\/. Date last accessed: 6 October 2022."},{"key":"2024101711510658000_9.2.00618-2022.45","doi-asserted-by":"crossref","first-page":"00078-02017","DOI":"10.1183\/23120541.00078-2017","article-title":"Adaptive servoventilation in clinical practice: beyond SERVE-HF?","volume":"3","author":"Randerath","year":"2017","journal-title":"ERJ Open Res"},{"key":"2024101711510658000_9.2.00618-2022.46","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3389\/fmed.2020.00105","article-title":"Adaptive servo-ventilation: a comprehensive descriptive study in the Geneva Lake Area","volume":"7","author":"Cantero","year":"2020","journal-title":"Front Med"},{"key":"2024101711510658000_9.2.00618-2022.47","first-page":"18","article-title":"Current and future use of adaptive servo-ventilation","volume":"2","author":"d'Ortho","year":"2016","journal-title":"Eur Respir Pulm Dis"},{"key":"2024101711510658000_9.2.00618-2022.48","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1186\/s12931-019-1221-9","article-title":"What is the remaining status of adaptive servo-ventilation? The results of a real-life multicenter study (OTRLASV-study)","volume":"20","author":"Jaffuel","year":"2019","journal-title":"Respir Res"},{"key":"2024101711510658000_9.2.00618-2022.49","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1007\/s00392-017-1112-3","article-title":"Whom are we treating with adaptive servo-ventilation? A clinical post hoc analysis","volume":"106","author":"Malfertheiner","year":"2017","journal-title":"Clin Res Cardiol"},{"key":"2024101711510658000_9.2.00618-2022.50","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.146522"},{"key":"2024101711510658000_9.2.00618-2022.51","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s11325-011-0486-0","article-title":"Prevalence and treatment of central sleep apnoea emerging after initiation of continuous positive airway pressure in patients with obstructive sleep apnoea without evidence of heart failure","volume":"16","author":"Westhoff","year":"2012","journal-title":"Sleep Breath"},{"key":"2024101711510658000_9.2.00618-2022.52","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.2450"},{"key":"2024101711510658000_9.2.00618-2022.53","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00354-2019"},{"key":"2024101711510658000_9.2.00618-2022.54","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1007\/s00392-018-1239-x","article-title":"Adaptive servo-ventilation to treat central sleep apnea in heart failure with reduced ejection fraction: the Bad Oeynhausen prospective ASV registry","volume":"107","author":"Oldenburg","year":"2018","journal-title":"Clin Res Cardiol"},{"key":"2024101711510658000_9.2.00618-2022.55","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1803180"},{"key":"2024101711510658000_9.2.00618-2022.56","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2017.11.003"},{"key":"2024101711510658000_9.2.00618-2022.57","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.01.041"},{"key":"2024101711510658000_9.2.00618-2022.58","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00063005"},{"key":"2024101711510658000_9.2.00618-2022.59","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.2006.00494.x"},{"key":"2024101711510658000_9.2.00618-2022.60","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1164\/rccm.202010-3943ST","article-title":"Informing healthcare decisions with observational research assessing causal effect. An Official American Thoracic Society research statement","volume":"203","author":"Gershon","year":"2021","journal-title":"Am J Respir Crit Care Med"}],"container-title":["ERJ Open Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/23120541.00618-2022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T05:23:35Z","timestamp":1740374615000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/23120541.00618-2022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,26]]},"references-count":60,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,4,17]]},"published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1183\/23120541.00618-2022"],"URL":"https:\/\/doi.org\/10.1183\/23120541.00618-2022","relation":{},"ISSN":["2312-0541"],"issn-type":[{"value":"2312-0541","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,26]]}}}