{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:35:45Z","timestamp":1782434145918,"version":"3.54.5"},"reference-count":26,"publisher":"European Respiratory Society (ERS)","issue":"4","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011033","name":"Thermo Fisher Scientific","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["BMBF 01EO1503"],"award-info":[{"award-number":["BMBF 01EO1503"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["ERJ Open Res"],"accepted":{"date-parts":[[2020,10,6]]},"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:p>While numerous studies have confirmed the prognostic role of high-sensitivity troponin T (hsTnT) in pulmonary embolism (PE), high-sensitivity troponin I (hsTnI) is inappropriately studied. This study aimed to investigate the prognostic relevance of hsTnI in normotensive PE, establish the optimal cut-off value for risk stratification and to compare the prognostic performances of hsTnI and hsTnT.<\/jats:p><jats:p>Based on data from 459 consecutive PE patients enrolled in a single-centre registry, receiver operating characteristic analysis was used to identify an optimal hsTnI cut-off value for prediction of in-hospital adverse outcomes (PE-related death, cardiopulmonary resuscitation or vasopressor treatment) and all-cause mortality.<\/jats:p><jats:p>Patients who suffered an in-hospital adverse outcome (4.8%) had higher hsTnI concentrations compared with those with a favourable clinical course (57 (interquartile range (IQR) 22\u2013197)<jats:italic>versus<\/jats:italic>15 (IQR 10\u201386) pg\u00b7mL<jats:sup>\u22121<\/jats:sup>, p=0.03). A hsTnI cut-off value of 16\u2005ng\u00b7mL<jats:sup>\u22121<\/jats:sup>provided optimal prognostic performance and predicted in-hospital adverse outcomes (OR 6.5, 95% CI 1.9\u201322.4) and all-cause mortality (OR 3.7, 95% CI 1.0\u201313.3). Between female and male patients, no relevant differences in hsTnI concentrations (17 (IQR 10\u201397)<jats:italic>versus<\/jats:italic>17 (IQR 10\u201392) pg\u00b7mL<jats:sup>\u22121<\/jats:sup>, p=0.79) or optimised cut-off values were observed. Risk stratification according to the 2019 European Society of Cardiology algorithm revealed no differences if calculated based on either hsTnI or hsTnT (p=0.68).<\/jats:p><jats:p>Our findings confirm the prognostic role of hsTnI in normotensive PE. HsTnI concentrations &gt;16\u2005pg\u00b7mL<jats:sup>\u22121<\/jats:sup>predicted in-hospital adverse outcome and all-cause mortality; sex-specific cut-off values do not seem necessary. Importantly, our results suggest that hsTnI and hsTnT can be used interchangeably for risk stratification.<\/jats:p>","DOI":"10.1183\/23120541.00625-2020","type":"journal-article","created":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T18:56:19Z","timestamp":1602788179000},"page":"00625-2020","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["High-sensitivity troponin I for risk stratification in normotensive pulmonary 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