{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T10:20:41Z","timestamp":1782210041989,"version":"3.54.5"},"reference-count":22,"publisher":"European Respiratory Society (ERS)","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Assistance Publique-H\u00f4pitaux de Marseille"}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["ERJ Open Res"],"accepted":{"date-parts":[[2020,12,2]]},"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Oesophageal pressure (<jats:italic>P<\/jats:italic><jats:sub>oes<\/jats:sub>) is used to approximate pleural pressure (<jats:italic>P<\/jats:italic><jats:sub>pl<\/jats:sub>) and therefore to estimate transpulmonary pressure (<jats:italic>P<\/jats:italic><jats:sub>L<\/jats:sub>). We aimed to compare oesophageal and regional pleural pressures and to calculate transpulmonary pressures in a prospective physiological study on lung transplant recipients during their stay in the intensive care unit of a tertiary university hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Lung transplant recipients receiving invasive mechanical ventilation and monitored by oesophageal manometry and dependent and nondependent pleural catheters were investigated during the post-operative period. We performed simultaneous short-time measurements and recordings of oesophageal manometry and pleural pressures. Expiratory and inspiratory<jats:italic>P<\/jats:italic><jats:sub>L<\/jats:sub>were computed by subtracting regional<jats:italic>P<\/jats:italic><jats:sub>pl<\/jats:sub>or<jats:italic>P<\/jats:italic><jats:sub>oes<\/jats:sub>from airway pressure; inspiratory<jats:italic>P<\/jats:italic><jats:sub>L<\/jats:sub>was also calculated with the elastance ratio method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>16 patients were included. Among them, 14 were analysed. Oesophageal pressures correlated with dependent and nondependent pleural pressures during expiration (R<jats:sup>2<\/jats:sup>=0.71, p=0.005 and R<jats:sup>2<\/jats:sup>=0.77, p=0.001, respectively) and during inspiration (R<jats:sup>2<\/jats:sup>=0.66 for both, p=0.01 and p=0.014, respectively).<jats:italic>P<\/jats:italic><jats:sub>L<\/jats:sub>values calculated using<jats:italic>P<\/jats:italic><jats:sub>oes<\/jats:sub>were close to those obtained from the dependent pleural catheter but higher than those obtained from the nondependent pleural catheter both during expiration and inspiration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In ventilated lung transplant recipients, oesophageal manometry is well correlated with pleural pressure. The absolute value of<jats:italic>P<\/jats:italic><jats:sub>oes<\/jats:sub>is higher than<jats:italic>P<\/jats:italic><jats:sub>pl<\/jats:sub>of nondependent lung regions and could therefore underestimate the highest level of lung stress in those at high risk of overinflation.<\/jats:p><\/jats:sec>","DOI":"10.1183\/23120541.00646-2020","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T19:15:32Z","timestamp":1611256532000},"page":"00646-2020","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Oesophageal pressure as a surrogate of pleural pressure in mechanically ventilated patients"],"prefix":"10.1183","volume":"7","author":[{"given":"Antoine","family":"Tilmont","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Coiffard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Daviet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Baumstarck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey","family":"Brioude","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami","family":"Hraiech","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marie","family":"Forel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Roch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Brochard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Papazian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Guervilly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2021,1,21]]},"reference":[{"key":"2024101711010475000_7.1.00646-2020.1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201703-0548ST"},{"key":"2024101711010475000_7.1.00646-2020.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0708638"},{"key":"2024101711010475000_7.1.00646-2020.3","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1164\/rccm.201709-1806OC","article-title":"Esophageal manometry and regional transpulmonary pressure in lung injury","volume":"197","author":"Yoshida","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"key":"2024101711010475000_7.1.00646-2020.4","first-page":"10","article-title":"Esophageal pressure measurements under different conditions of intrathoracic pressure. 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