{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T08:57:26Z","timestamp":1765961846737,"version":"3.40.2"},"reference-count":34,"publisher":"European Respiratory Society (ERS)","issue":"2","license":[{"start":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T00:00:00Z","timestamp":1728000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100027896","name":"Patrick J. McGovern Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100027896","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["ERJ Open Res"],"accepted":{"date-parts":[[2024,9,18]]},"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Recent advances in digital and wearable technologies with artificial intelligence (AI) enable the use of continuous cough monitoring (CCM) to objectively monitor symptoms as surrogate markers of treatment efficacy in pulmonary tuberculosis (PTB). The objectives of this study were to describe the evolution of cough during PTB treatment in adults and to assess the feasibility of community-based CCM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively enrolled PTB adult participants upon treatment initiation. Participants\u2019 coughs were continuously monitored during 6\u2005months with a smartphone loaded with an app able to detect cough by using an AI algorithm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>22 participants were included. The median (interquartile range (IQR)) age was 28.5 (22\u201342)\u2005years and 62% were male. The median (IQR) coughs per hour (medCPH) was 11.0 (7.0\u201327.0) at week 1. By the end of the intensive phase of PTB treatment at week 8, the medCPH was 3.5 (1.5\u20137.0), which was significantly lower than the medCPH at week 1 (p=0.002). At week 26 (end of treatment), the medCPH was 1.0 (1.0\u20132.5). The adherence to CCM was high during the first 13\u2005weeks of PTB treatment and then waned over time. The adherence was similar during daytime and night-time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cough counts rapidly drop during the intensive phase of PTB treatment and then slowly decrease to a low baseline level by the end of the treatment. Community-based CCM using digital technology is feasible in low-resource settings but requires evaluation of alternative approaches to overcome adherence issues and technical limitations (mobile internet and electricity availability).<\/jats:p><\/jats:sec>","DOI":"10.1183\/23120541.00655-2024","type":"journal-article","created":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T16:00:17Z","timestamp":1728057617000},"page":"00655-2024","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Continuous digital cough monitoring during 6-month pulmonary tuberculosis treatment"],"prefix":"10.1183","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8857-5834","authenticated-orcid":false,"given":"Mihaja","family":"Raberahona","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Zimmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rivonirina Andry","family":"Rakotoarivelo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick Andriniaina","family":"Randrianarisoa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Garcia","family":"Rambeloson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Etienne","family":"Rakotomijoro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe Elody","family":"Andry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haingonirina Anique","family":"Razafindrakoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dera","family":"Andriantahiana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamy Jean de Dieu","family":"Randria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2352-9797","authenticated-orcid":false,"given":"Niaina","family":"Rakotosamimanana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3646-1573","authenticated-orcid":false,"given":"Simon","family":"Grandjean Lapierre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2024,10,4]]},"reference":[{"key":"2025032403450665000_11.2.00655-2024.1","unstructured":"World Health Organization . Global tuberculosis report 2023. 2022. https:\/\/iris.who.int\/bitstream\/handle\/10665\/373828\/9789240083851-eng.pdf Date last accessed: 6 December 2024."},{"key":"2025032403450665000_11.2.00655-2024.2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(23)00375-4"},{"key":"2025032403450665000_11.2.00655-2024.3","unstructured":"World Health Organization \u2013 African Region . 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