{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T12:37:39Z","timestamp":1793191059989,"version":"4.5.0"},"reference-count":23,"publisher":"European Respiratory Society (ERS)","issue":"1","license":[{"start":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T00:00:00Z","timestamp":1698278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Pulmonx Corporation","award":["has supported data analysis of the current analysi"],"award-info":[{"award-number":["has supported data analysis of the current analysi"]}]},{"name":"Emphasys Medical Inc","award":["supported the original VENT trial"],"award-info":[{"award-number":["supported the original VENT trial"]}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["ERJ Open Res"],"accepted":{"date-parts":[[2023,10,19]]},"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background and objective<\/jats:title>\n                    <jats:p>Rehabilitation programmes are a valuable treatment modality for patients with COPD to increase exercise capacity and quality of life. The utility of pulmonary rehabilitation prior to bronchoscopic lung volume reduction (BLVR) is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We performed a\n                      <jats:italic>post hoc<\/jats:italic>\n                      analysis of the Valve for Emphysema Palliation Trial (VENT) trial, the first multicentre randomised trial comparing the safety and efficacy of BLVR. Patients completed a pulmonary rehabilitation programme prior to BLVR over 6\u201310\u2005weeks and maintained by daily practice, consisting of endurance training, strength training and upper\/lower limb exercise. Lung function and exercise parameters (6-min walk distance (6MWD)) were assessed before and after rehabilitation and we tried to identify predictors for pulmonary rehabilitation benefit.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Lung function and exercise capacity of 403 patients (mean\n                      <jats:sc>\u00b1sd<\/jats:sc>\n                      age 63.3\u00b17.4\u2005years, 37.5% female, mean\u00b1\n                      <jats:sc>sd<\/jats:sc>\n                      forced expiratory volume in 1\u2005s 30.1\u00b17.6\u2005L) were analysed. Exercise capacity significantly improved from 331.6\u00b198.8 m to 345.6\u00b195.3\u2005m (p&lt;0.001) in 6-min walk testing (6MWT), with 40.3% showing clinically meaningful improvements. Patients also experienced less dyspnoea after 6MWT, while pulmonary function parameters did not change significantly overall. Patients with lower exercise capacity at screening (6MWD &lt;250\u2005m) benefited more from pulmonary rehabilitation. The indication and prerequisites for BLVR were still present in all patients after pulmonary rehabilitation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The national mandatory requirements for rehabilitation prior to BLVR, which apply to all COPD patients, should be reconsidered and specified for COPD patients who really benefit.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1183\/23120541.00735-2023","type":"journal-article","created":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T08:00:13Z","timestamp":1698307213000},"page":"00735-2023","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Utility of rehabilitation prior to bronchoscopic lung volume reduction:\n                    <i>post hoc<\/i>\n                    analysis of the VENT trial"],"prefix":"10.1183","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0228-548X","authenticated-orcid":false,"given":"Judith Maria","family":"Brock","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9798-9879","authenticated-orcid":false,"given":"Konstantina","family":"Kontogianni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank C.","family":"Sciurba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard J.","family":"Criner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7638-2506","authenticated-orcid":false,"given":"Felix","family":"Herth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2023,10,26]]},"reference":[{"key":"2024101712083886000_10.1.00735-2023.1","unstructured":"Global Initiative for Chronic Obstructive Lung Disease (GOLD) . Global Strategy for the Diagnosis, Management and Prevention of Chronic Obstructive Pulmonary Disease: 2023 Report. 2023. https:\/\/goldcopd.org\/2023-gold-report-2\/."},{"key":"2024101712083886000_10.1.00735-2023.2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00124605"},{"key":"2024101712083886000_10.1.00735-2023.3","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200707-1064OC"},{"key":"2024101712083886000_10.1.00735-2023.4","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201501-0157OC"},{"key":"2024101712083886000_10.1.00735-2023.5","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00007809"},{"key":"2024101712083886000_10.1.00735-2023.6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030287"},{"key":"2024101712083886000_10.1.00735-2023.7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0900928"},{"key":"2024101712083886000_10.1.00735-2023.8","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201803-0590OC"},{"key":"2024101712083886000_10.1.00735-2023.9","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201607-1383OC"},{"key":"2024101712083886000_10.1.00735-2023.10","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1159\/000496122","article-title":"Endoscopic lung volume reduction: an expert panel recommendation \u2013 update 2019","volume":"97","author":"Herth","year":"2019","journal-title":"Respiration"},{"key":"2024101712083886000_10.1.00735-2023.11","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00161611"},{"key":"2024101712083886000_10.1.00735-2023.12","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-7-10"},{"key":"2024101712083886000_10.1.00735-2023.13","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00063810"},{"key":"2024101712083886000_10.1.00735-2023.14","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201510-1966ST"},{"key":"2024101712083886000_10.1.00735-2023.15","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003793.pub3"},{"key":"2024101712083886000_10.1.00735-2023.16","first-page":"419","article-title":"Effects of pulmonary rehabilitation on lung function in chronic obstructive pulmonary disease: the FIRST study","volume":"50","author":"Incorvaia","year":"2014","journal-title":"Eur J Phys Rehabil Med"},{"key":"2024101712083886000_10.1.00735-2023.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2007.04.007"},{"key":"2024101712083886000_10.1.00735-2023.18","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.21037\/apm-22-451","article-title":"Efficacy and safety of pulmonary rehabilitation training on lung function, quality of life, and T cell immune function in patients with stable chronic obstructive pulmonary disease: a randomized controlled trial","volume":"11","author":"Ma","year":"2022","journal-title":"Ann Palliat Med"},{"key":"2024101712083886000_10.1.00735-2023.19","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201309-1634ST"},{"key":"2024101712083886000_10.1.00735-2023.20","doi-asserted-by":"publisher","DOI":"10.3109\/15412555.2012.705365"},{"key":"2024101712083886000_10.1.00735-2023.21","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00130605"},{"key":"2024101712083886000_10.1.00735-2023.22","doi-asserted-by":"publisher","DOI":"10.1097\/00008483-199907000-00004"},{"key":"2024101712083886000_10.1.00735-2023.23","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.6.3799"}],"container-title":["ERJ Open Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/23120541.00735-2023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:30:20Z","timestamp":1740357020000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/23120541.00735-2023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,26]]},"references-count":23,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1,22]]},"published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1183\/23120541.00735-2023"],"URL":"https:\/\/doi.org\/10.1183\/23120541.00735-2023","relation":{},"ISSN":["2312-0541"],"issn-type":[{"value":"2312-0541","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,26]]}}}