{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T13:38:39Z","timestamp":1784209119506,"version":"3.55.0"},"reference-count":40,"publisher":"European Respiratory Society (ERS)","issue":"4","license":[{"start":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:00:00Z","timestamp":1738281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["ERJ Open Res"],"accepted":{"date-parts":[[2025,1,5]]},"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Bronchiectasis disease is characterised by cough, sputum and exacerbations, with chest computed tomography (CT) typically showing bronchial wall thickening and mucus plugging in addition to bronchial dilation. Asthma is a common comorbidity and associated with increased, eosinophilic, airway inflammation. Automated measurements of bronchial wall thickening and mucus plugs may serve as biomarkers for inflammation and are associated with clinical characteristics such as spirometry, blood eosinophil counts and disease severity in patients with bronchiectasis and asthma co-diagnosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In a cross-sectional retrospective cohort of 64 patients with bronchiectasis disease and asthma, we applied automated image analysis to assess bronchial dimensions and mucus plug metrics on chest CT scans. These metrics were correlated with spirometry, blood eosinophil counts as well as FACED and Bronchiectasis Severity Index (BSI) scores using correlations and multiple regression analyses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In 63 patients, bronchial wall thickness and mucus plugs were quantified. Negative correlations were observed between bronchial wall thickness markers and spirometry (bronchial wall thickness\/accompanying artery diameter and forced expiratory volume in 1\u2005s (FEV<jats:sub>1<\/jats:sub>), r=\u2009\u22120.37; FEV<jats:sub>1<\/jats:sub>\/forced vital capacity, r=\u2009\u22120.30). Mucus plugs correlated negatively with spirometry and positively with FACED and BSI scores (number of mucus plugs and BSI, r=0.45). Correlations with blood eosinophil counts were very weak. In multiple regression analyses, independent associations were observed for FEV<jats:sub>1<\/jats:sub>, <jats:italic>Pseudomonas aeruginosa<\/jats:italic> and frequent exacerbations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This study identified key relationships between automated measurements of bronchial wall thickness and mucus plugs and clinical characteristics, highlighting their potential as imaging biomarkers to enhance phenotyping, improve risk assessment and facilitate tailored treatment strategies in bronchiectasis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1183\/23120541.00736-2024","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T06:45:24Z","timestamp":1738305924000},"page":"00736-2024","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Automated computed tomographic analysis of bronchial thickness and mucus plugs in bronchiectasis with asthma"],"prefix":"10.1183","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3085-603X","authenticated-orcid":false,"given":"Tjeerd","family":"van der Veer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni-Rosalina","family":"Andrinopoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Punitkumar","family":"Makani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7671-3742","authenticated-orcid":false,"given":"Gert-Jan","family":"Braunstahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5628-6667","authenticated-orcid":false,"given":"Harm A.W.M.","family":"Tiddens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2025,1,31]]},"reference":[{"key":"2025090103100942000_11.4.00736-2024.1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(21)00277-0"},{"key":"2025090103100942000_11.4.00736-2024.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31767-7"},{"key":"2025090103100942000_11.4.00736-2024.3","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(24)00176-0"},{"key":"2025090103100942000_11.4.00736-2024.4","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1164\/rccm.202311-2109OC","article-title":"Structural lung disease and clinical phenotype in bronchiectasis patients: the EMBARC CT study","volume":"210","author":"Pieters","year":"2024","journal-title":"Am J Respir Crit Care Med"},{"key":"2025090103100942000_11.4.00736-2024.5","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0234-2023"},{"key":"2025090103100942000_11.4.00736-2024.6","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.jcf.2023.05.013","article-title":"Automatic bronchus and artery analysis on chest computed tomography to evaluate the effect of inhaled hypertonic saline in children aged 3\u20136\u2005years with cystic fibrosis in a randomized clinical trial","volume":"22","author":"Chen","year":"2023","journal-title":"J Cyst Fibros"},{"key":"2025090103100942000_11.4.00736-2024.7","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1136\/thorax-2023-220021","article-title":"Automatic analysis of bronchus\u2013artery dimensions to diagnose and monitor airways disease in cystic fibrosis","volume":"79","author":"Lv","year":"2023","journal-title":"Thorax"},{"key":"2025090103100942000_11.4.00736-2024.8","doi-asserted-by":"crossref","first-page":"e221109","DOI":"10.1148\/radiol.221109","article-title":"Artificial intelligence-based CT assessment of bronchiectasis: the COPDGene study","volume":"307","author":"D\u00edaz","year":"2023","journal-title":"Radiology"},{"key":"2025090103100942000_11.4.00736-2024.9","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00231-2024"},{"key":"2025090103100942000_11.4.00736-2024.10","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00121-2024"},{"key":"2025090103100942000_11.4.00736-2024.11","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.congress-2024.PA652"},{"key":"2025090103100942000_11.4.00736-2024.12","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1016\/S1569-1993(24)00197-8","article-title":"WS15.05 Improvements in structural lung disease in people with CF aged 12 and above on elexacaftor\/tezacaftor\/ivacaftor are sustained for up to two years","volume":"23","author":"McNally","year":"2024","journal-title":"J Cyst Fibros"},{"key":"2025090103100942000_11.4.00736-2024.13","doi-asserted-by":"crossref","unstructured":"Tiddens HAWM , Van Der Veer T , Charbonnier J-P , et al. Fully automated mucus plug quantification on chest CTs and its correlation with all-cause mortality. Am J Respir Clin Care Med 2024; 209: A2778. doi:10.1164\/ajrccm-conference.2024.209.1_MeetingAbstracts.A2778","DOI":"10.1164\/ajrccm-conference.2024.209.1_MeetingAbstracts.A2778"},{"key":"2025090103100942000_11.4.00736-2024.14","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.jaip.2022.10.027","article-title":"Significance and potential role of eosinophils in non-cystic fibrosis bronchiectasis","volume":"11","author":"Guan","year":"2023","journal-title":"J Allergy Clin Immunol Pract"},{"key":"2025090103100942000_11.4.00736-2024.15","doi-asserted-by":"publisher","DOI":"10.1172\/JCI95693"},{"key":"2025090103100942000_11.4.00736-2024.16","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202108-1889OC"},{"key":"2025090103100942000_11.4.00736-2024.17","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.chest.2021.04.013","article-title":"Eosinophilic and noneosinophilic asthma: an expert consensus framework to characterize phenotypes in a global real-life severe asthma cohort","volume":"160","author":"Heaney","year":"2021","journal-title":"Chest"},{"key":"2025090103100942000_11.4.00736-2024.18","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00328-2018"},{"key":"2025090103100942000_11.4.00736-2024.19","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1080\/02770903.2023.2203743","article-title":"Does asthma\u2013bronchiectasis overlap syndrome (ABOS) really exist?","volume":"60","author":"Tiotiu","year":"2023","journal-title":"J Asthma"},{"key":"2025090103100942000_11.4.00736-2024.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2024.01.027"},{"key":"2025090103100942000_11.4.00736-2024.21","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.rmed.2018.05.008","article-title":"Acute respiratory events in patients with bronchiectasis\u2013COPD overlap syndrome: a population-based cohort study","volume":"140","author":"Chung","year":"2018","journal-title":"Respir Med"},{"key":"2025090103100942000_11.4.00736-2024.22","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(23)00093-0"},{"key":"2025090103100942000_11.4.00736-2024.23","first-page":"1","article-title":"Bronchiectasis in severe asthma: does it make a difference?","volume":"15","author":"Bendien","year":"2020","journal-title":"Respiration"},{"key":"2025090103100942000_11.4.00736-2024.24","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1152\/japplphysiol.00403.2021","article-title":"Small airways vs large airways in asthma: time for a new perspective","volume":"131","author":"Donovan","year":"2021","journal-title":"J Appl Physiol"},{"key":"2025090103100942000_11.4.00736-2024.25","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201908-1590ST"},{"key":"2025090103100942000_11.4.00736-2024.26","unstructured":"Federatie Medisch Specialisten . NVALT richtlijnen: bronchi\u00ebctasie\u00ebn. [NVALT guidelines: bronchiectasis.] 2017. Date last accessed: 27 May 2024. https:\/\/richtlijnendatabase.nl\/richtlijn\/bronchiectasieen\/startpagina_bronchiectasieen.html"},{"key":"2025090103100942000_11.4.00736-2024.27","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00026313"},{"key":"2025090103100942000_11.4.00736-2024.28","doi-asserted-by":"publisher","DOI":"10.2174\/1874306401509010046"},{"key":"2025090103100942000_11.4.00736-2024.29","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00167908"},{"key":"2025090103100942000_11.4.00736-2024.30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcm.2016.02.012"},{"key":"2025090103100942000_11.4.00736-2024.31","doi-asserted-by":"crossref","first-page":"174","DOI":"10.4168\/aair.2023.15.2.174","article-title":"Relationships between high-resolution computed tomographic features and lung function trajectory in patients with asthma","volume":"15","author":"Kim","year":"2023","journal-title":"Allergy Asthma Immunol Res"},{"key":"2025090103100942000_11.4.00736-2024.32","doi-asserted-by":"crossref","first-page":"103788","DOI":"10.1016\/j.resp.2021.103788","article-title":"Impact of bronchial wall thickness on airflow obstruction in bronchiectasis","volume":"295","author":"Yamamoto","year":"2022","journal-title":"Respir Physiol Neurobiol"},{"key":"2025090103100942000_11.4.00736-2024.33","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00020714"},{"key":"2025090103100942000_11.4.00736-2024.34","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200211-1268OC"},{"key":"2025090103100942000_11.4.00736-2024.35","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01865-2021"},{"key":"2025090103100942000_11.4.00736-2024.36","doi-asserted-by":"crossref","first-page":"2416836","DOI":"10.1016\/j.pulmoe.2023.11.006","article-title":"Reliability of blood eosinophil count in steady-state bronchiectasis","volume":"31","author":"Martinez-Garcia","year":"2024","journal-title":"Pulmonology"},{"key":"2025090103100942000_11.4.00736-2024.37","doi-asserted-by":"crossref","first-page":"e202307451","DOI":"10.1002\/anie.202307451","article-title":"A rapid sputum-based lateral flow assay for airway eosinophilia using an RNA-cleaving DNAzyme selected for eosinophil peroxidase","volume":"62","author":"Ali","year":"2023","journal-title":"Angew Chem Int Ed Engl"},{"key":"2025090103100942000_11.4.00736-2024.38","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.2065"},{"key":"2025090103100942000_11.4.00736-2024.39","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01953-2017"},{"key":"2025090103100942000_11.4.00736-2024.40","doi-asserted-by":"publisher","DOI":"10.1080\/17476348.2021.1906225"}],"container-title":["ERJ Open Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/23120541.00736-2024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T10:10:20Z","timestamp":1756721420000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/23120541.00736-2024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,31]]},"references-count":40,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,8,4]]},"published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1183\/23120541.00736-2024"],"URL":"https:\/\/doi.org\/10.1183\/23120541.00736-2024","relation":{},"ISSN":["2312-0541"],"issn-type":[{"value":"2312-0541","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,31]]}}}