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This narrative review examines the epidemiological, pathophysiological, clinical and therapeutic implications of\n                    <jats:italic>S. aureus<\/jats:italic>\n                    infection in adults with bronchiectasis, drawing comparisons with other disease models. Epidemiological data reveal a lower prevalence of\n                    <jats:italic>S. aureus<\/jats:italic>\n                    in bronchiectasis compared to other pathogens, with significant regional variation. Its clinical impact is debated, with some studies associating chronic\n                    <jats:italic>S. aureus<\/jats:italic>\n                    infection with more severe disease, while others consider it a marker of severity rather than a direct driver of progression. Unlike\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    , current guidelines do not recommend specific eradication or long-term suppressive strategies for\n                    <jats:italic>S. aureus<\/jats:italic>\n                    . British guidelines suggest MRSA eradication may be considered in cases of clinical deterioration, although no standardised protocol exists. Exacerbations are managed with a 14-day course of targeted antibiotics. Preventive strategies, including decolonisation and vaccine development, are under investigation or adapted from other clinical contexts. While no vaccine is currently available, monoclonal antibodies targeting\n                    <jats:italic>S. aureus<\/jats:italic>\n                    toxins have shown promise in early trials. Further research is needed to clarify the pathogen's role in disease progression and the efficacy of targeted therapies. This review also outlines clinical practice points and research priorities to support evidence-based management.\n                  <\/jats:p>","DOI":"10.1183\/23120541.00740-2025","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T18:50:20Z","timestamp":1765479020000},"page":"00740-2025","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>S<\/i>\n                    <i>taphylococcus aureus<\/i>\n                    in bronchiectasis: epidemiology, clinical impact and challenges in management"],"prefix":"10.1183","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3544-0361","authenticated-orcid":false,"given":"Alessandro","family":"De Angelis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Lo 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