{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T15:50:10Z","timestamp":1791993010225,"version":"4.4.0"},"reference-count":26,"publisher":"European Respiratory Society (ERS)","issue":"2","license":[{"start":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T00:00:00Z","timestamp":1736294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["ERJ Open Res"],"accepted":{"date-parts":[[2024,10,5]]},"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec><jats:title>Question<\/jats:title><jats:p>The reference test for the functional evaluation of pulmonary fibrosis (PF) during exercise is the 6-min walk test (6MWT). However, the 6MWT involves temporal and spatial constraints that the 1-min sit-to-stand test (1-MSTST) does not have. Previous studies have not validated 1-MSTST use in this context, mainly because of far less oxygen desaturation. We hypothesise that the modified 1-MSTST (m1-MSTST), taking into account the recovery phase, could compensate this shortcoming.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>This was a randomised, crossover, single-centre trial conducted in 36 patients with PF. A 6MWT and 1-MSTST were performed 30\u2005min apart for each patient in a randomised order. An equivalence test was performed on the peripheral oxygen saturation (<jats:italic>S<\/jats:italic><jats:sub>pO<jats:sub>2<\/jats:sub><\/jats:sub>) nadir.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 36 patients comprised eight with idiopathic PF, five with nonspecific idiopathic pneumonia, eight with collagen tissue disease-associated PF, four with hypersensitivity pneumonitis, two with sarcoidosis and nine with other PF. Mean\u00b1<jats:sc>sd<\/jats:sc>nadir desaturation was 84.9\u00b14.3% for the 6MWT and 88\u00b13.5% for the m1-MSTST, with a strong correlation between both tests. 33 patients (91.7%) had concordant results in the two tests regarding significant desaturation (<jats:italic>S<\/jats:italic><jats:sub>pO<jats:sub>2<\/jats:sub><\/jats:sub>delta &gt;4% or nadir &lt;88%), which is a known prognosis factor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The m1-MSTST, taking into account the recovery phase, is a sensible compromise to the 6MWT in measuring exercise performance in people with PF. As many clinical endpoints transfer from hospital to outpatient care, the m1-MSTST is technically easier and more practical for patients. Further studies are warranted to determine the minimal clinically important difference and norms in healthy subjects.<\/jats:p><\/jats:sec>","DOI":"10.1183\/23120541.00745-2024","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T01:20:15Z","timestamp":1736385615000},"page":"00745-2024","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Modified 1-min sit-to-stand test for evaluating exercise capacity in pulmonary fibrosis"],"prefix":"10.1183","volume":"11","author":[{"given":"Ingrid","family":"Berger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadek","family":"Mortada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9mence","family":"Gachie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Beaussier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Sacco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Chatellier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Fels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marine","family":"Cachanado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0915-3228","authenticated-orcid":false,"given":"Jean-Marc","family":"Naccache","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2025,1,8]]},"reference":[{"key":"2025041402450782000_11.2.00745-2024.1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202202-0399ST"},{"key":"2025041402450782000_11.2.00745-2024.2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.13-1474"},{"key":"2025041402450782000_11.2.00745-2024.3","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.166.1.at1102"},{"key":"2025041402450782000_11.2.00745-2024.4","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00150314"},{"key":"2025041402450782000_11.2.00745-2024.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2015.04.008"},{"key":"2025041402450782000_11.2.00745-2024.6","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.2.ats3-00"},{"key":"2025041402450782000_11.2.00745-2024.7","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200302-219OC"},{"key":"2025041402450782000_11.2.00745-2024.8","first-page":"907","article-title":"AARC clinical practice guideline. 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