{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:09:34Z","timestamp":1772165374653,"version":"3.50.1"},"reference-count":42,"publisher":"European Respiratory Society (ERS)","issue":"2","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011199","name":"FP7 Ideas: European Research Council","doi-asserted-by":"publisher","award":["668954"],"award-info":[{"award-number":["668954"]}],"id":[{"id":"10.13039\/100011199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["095778"],"award-info":[{"award-number":["095778"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["102512"],"award-info":[{"award-number":["102512"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["204928\/Z\/16\/Z"],"award-info":[{"award-number":["204928\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/L004623\/1"],"award-info":[{"award-number":["MR\/L004623\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["ERJ Open Res"],"accepted":{"date-parts":[[2021,3,5]]},"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:p>The reasons for the positive association between anxiety disorders and asthma are unknown. We investigated the possible role of shared exposures in early life.<\/jats:p>\n                  <jats:p>We conducted a case\u2013control study among adolescents (age 12\u201317\u2005years) with and without asthma in urban Uganda, as part of a larger asthma case\u2013control study. Anxiety disorders were diagnosed by psychiatric clinical officers. We focused on generalised anxiety disorder (GAD), panic disorder and social anxiety disorder. Asthma was doctor-diagnosed by study clinicians. We used questionnaires to collect data on early-life exposures. The data were analysed using multiple logistic regression.<\/jats:p>\n                  <jats:p>We enrolled 162 adolescents; 73 of them had asthma. Adolescents with asthma were more likely to have any of the three anxiety disorders studied (46.6%) than adolescents without asthma (21.4%) (adjusted OR (aOR) 2.68, 95% CI 1.30\u20135.53). The association was strong for GAD (aOR 4.49, 95% CI 1.48\u201313.56) and panic disorder (aOR 5.43, 95% CI 2.11\u201314.02), but not for social anxiety disorder. The early-life risk factors associated with anxiety disorders among adolescents were similar to asthma risk factors previously published, including urban residence at birth (aOR 3.42, 95% CI 1.29\u20139.09) and during most of the first 5\u2005years of life (aOR 2.87, 95% CI 1.07\u20137.66), father's tertiary education (aOR 2.09, 95% CI 1.00\u20134.37), and adolescent's history of other allergy-related diseases (aOR 4.64, 95% CI 1.66\u201313.00).<\/jats:p>\n                  <jats:p>We confirm a positive association between anxiety disorders and asthma among adolescents in urban Uganda. The early-life risk factors associated with anxiety disorders among adolescents were similar to those for asthma in the same age group, suggesting shared underlying environmental exposures.<\/jats:p>","DOI":"10.1183\/23120541.00749-2020","type":"journal-article","created":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T12:24:48Z","timestamp":1618489488000},"page":"00749-2020","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Anxiety disorders and asthma among adolescents in Uganda: role of early-life exposures"],"prefix":"10.1183","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1199-4859","authenticated-orcid":false,"given":"Harriet","family":"Mpairwe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard Stephen","family":"Mpango","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilber","family":"Sembajjwe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily L.","family":"Webb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison M.","family":"Elliott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil","family":"Pearce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugene","family":"Kinyanda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2021,4,15]]},"reference":[{"key":"2024101711072286000_7.2.00749-2020.1","unstructured":"World Health Organization . 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