{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:04:16Z","timestamp":1793052256752,"version":"4.5.0"},"reference-count":0,"publisher":"European Respiratory Society (ERS)","license":[{"start":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:00:00Z","timestamp":1733961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019967","name":"Lung Health Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019967","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003579","name":"University of Toronto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003579","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["ERJ Open Res"],"accepted":{"date-parts":[[2024,12,1]]},"abstract":"<jats:sec><jats:title>Rationale<\/jats:title><jats:p>The impact of continuous positive airway pressure (CPAP) is currently unknown in patients with pulmonary arterial hypertension (PAH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the effect of CPAP on cardiopulmonary hemodynamics in patients with (PAH) compared to healthy volunteers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All participants underwent an esophageal catheter insertion followed by right heart catherization with and without the application of CPAP at 10\u2005cm H<jats:sub>2<\/jats:sub>0. The primary outcome was the effect of CPAP on cardiopulmonary hemodynamics and intrapleural pressures within and between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In both PAH (n= 18) and healthy (n=5) participants the acute application of CPAP increased the esophageal pressure significantly from baseline (all p&lt;0.007). There was a decline in cardiac output in both groups from baseline (p=0.047), which was due to a reduction in heart rate (p=0.027) rather than stroke volume (p=0.8). CPAP significantly reduced right ventricular end diastolic pressure (p=0.02), without a significant impact on resistive right ventricular afterload. CPAP did not significantly change pulmonary artery or pulmonary vascular resistance in either group. The calculated dynamic pulmonary arterial compliance was increased in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In PAH and healthy participants, CPAP had a modest effect on intrapleural pressures. The transmural hemodynamic changes of CPAP were modest with a net increase in pulmonary vascular compliance in both groups, but no change in resistive right ventricular afterload in the PAH group. The current study did not demonstrate any deleterious effects of CPAP on pulmonary hemodynamics.<\/jats:p><\/jats:sec>","DOI":"10.1183\/23120541.00796-2024","type":"journal-article","created":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T04:01:59Z","timestamp":1734062519000},"page":"00796-2024","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of Positive Airway Pressure on Right Ventricular Afterload in Pulmonary Arterial Hypertension"],"prefix":"10.1183","author":[{"given":"Robert F.","family":"Bentley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaun W.","family":"Yo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.H.","family":"Mok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe H.","family":"Valle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewan C.","family":"Goligher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina Gonzaga","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T.","family":"Granton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna S","family":"Mak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2372-965X","authenticated-orcid":false,"given":"Clodagh M.","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2024,12,12]]},"container-title":["ERJ Open Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/23120541.00796-2024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T12:16:40Z","timestamp":1743164200000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/23120541.00796-2024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,12]]},"references-count":0,"alternative-id":["10.1183\/23120541.00796-2024"],"URL":"https:\/\/doi.org\/10.1183\/23120541.00796-2024","relation":{},"ISSN":["2312-0541"],"issn-type":[{"value":"2312-0541","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,12]]}}}