{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T02:03:28Z","timestamp":1769047408490,"version":"3.49.0"},"reference-count":30,"publisher":"European Respiratory Society (ERS)","issue":"2","license":[{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/M022552\/1"],"award-info":[{"award-number":["MR\/M022552\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["ERJ Open Res"],"accepted":{"date-parts":[[2024,10,11]]},"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Intra-breath oscillometry potentially offers detailed information regarding airway function, with increasing magnitude of difference between resistance and reactance at end-expiration to end-inspiration potentially associated with obstructive airway disease, but less is known about specific respiratory mechanics in preterm-born children using this methodology. We investigated whether different spirometry phenotypes of prematurity-associated lung disease (PLD) have specific intra-breath oscillometry features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>167 school-aged (7\u201312\u2005years) children, 14 with prematurity-associated obstructive lung disease (POLD; forced expiratory volume in 1\u2005s (FEV<jats:sub>1<\/jats:sub>) &lt;lower limit of normal (LLN), FEV<jats:sub>1<\/jats:sub>\/forced vital capacity (FVC) &lt;LLN), 11 with prematurity-associated preserved ratio impaired spirometry (pPRISm; FEV<jats:sub>1<\/jats:sub>&lt;LLN, FEV<jats:sub>1<\/jats:sub>\/FVC \u2265LLN), 90 preterm controls (FEV<jats:sub>1<\/jats:sub>\u2265LLN) and 52 term controls, performed intra-breath oscillometry at baseline, following maximal cardiopulmonary exercise testing and following post-exercise bronchodilation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Children with POLD showed greater resistance and more negative reactance throughout the respiratory cycle, including at zero-flow states of end-expiration and end-inspiration. The difference between end-expiration and end-inspiration did not show differences between groups until corrected for tidal volume, whereby children with POLD and pPRISm both demonstrated approximately two-fold greater difference compared to both preterm and term controls for resistance (2.24 and 2.22<jats:italic>versus<\/jats:italic>1.28 and 1.11\u2005hPa\u00b7s\u00b7L<jats:sup>\u22121<\/jats:sup>, respectively), and in particular a greater magnitude of difference for reactance for children with POLD<jats:italic>versus<\/jats:italic>preterm and term controls only (\u22121.58<jats:italic>versus<\/jats:italic>\u22120.26 and 0.03\u2005hPa\u00b7s\u00b7L<jats:sup>\u22121<\/jats:sup>, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intra-breath respiratory mechanics for preterm-born children with an obstructive lung phenotype have greater impedance throughout the respiratory cycle, features different to those observed in children with other wheeze phenotypes including preschool wheeze and asthma.<\/jats:p><\/jats:sec>","DOI":"10.1183\/23120541.00840-2024","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T16:55:13Z","timestamp":1730998513000},"page":"00840-2024","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Intra-breath respiratory mechanics of prematurity-associated lung disease phenotypes in school-aged children"],"prefix":"10.1183","volume":"11","author":[{"given":"Michael","family":"Cousins","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kylie","family":"Hart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bence","family":"Radics","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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