{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T01:52:37Z","timestamp":1781661157219,"version":"3.54.5"},"reference-count":40,"publisher":"European Respiratory Society (ERS)","issue":"3","license":[{"start":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T00:00:00Z","timestamp":1731542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K08649"],"award-info":[{"award-number":["19K08649"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K08233"],"award-info":[{"award-number":["22K08233"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K08271"],"award-info":[{"award-number":["22K08271"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["ERJ Open Res"],"accepted":{"date-parts":[[2024,10,17]]},"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Dipeptidyl peptidase 1 (DPP1) exacerbates airway neutrophilic inflammation in bronchiectasis, which is characterised by airway dysfunction and dilation and chronic bacterial infection. However, little is known about the pathogenetic roles of DPP1 in obstructive airway diseases, including COPD, asthma and asthma\u2013COPD overlap (ACO). Here, we tested the hypothesis that airway DPP1 could enhance neutrophilic inflammation and affect mucus plugging, airway dilation and the airway microbiome in patients with these diseases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Sputum DPP1, cell differential count and microbiome were cross-sectionally evaluated in patients with COPD, asthma with airflow limitation and ACO. Sputum high mobility group box 1 (HMGB1) was measured to estimate airway epithelial damage. Chest computed tomography was also performed to visually assess mucus plugs and airway dilation with the Reiff score and quantify the total airway count and wall area percentage.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>68 patients were classified into high-DPP1\/high-neutrophil (n=17), low-DPP1\/high-neutrophil (n=37) and low-neutrophil (n=14) groups based on sputum DPP1 levels and neutrophil percentages. The rate of mucus plugging and the relative abundance of the phylum Firmicutes were significantly lower and the level of sputum HMGB1 was significantly greater in the high-DPP1\/high-neutrophil group than in the low-DPP1\/high-neutrophil group. Moreover, airway dilation without mucus plugging was observed only in the high-DPP1\/high-neutrophil group (prevalence 29%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>High sputum DPP1 levels may reduce colonisation by the phylum Firmicutes and mucus plugging, but increase airway epithelial damage, which could induce airway dilation without mucus plugging in patients with obstructive airway disease with neutrophilic inflammation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1183\/23120541.00841-2024","type":"journal-article","created":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T15:45:22Z","timestamp":1731599122000},"page":"00841-2024","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Exploring the roles of airway dipeptidyl peptidase 1 in obstructive airway disease"],"prefix":"10.1183","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7481-0212","authenticated-orcid":false,"given":"Naoya","family":"Tanabe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8754-6318","authenticated-orcid":false,"given":"Hisako","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariko","family":"Kogo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chie","family":"Morimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natsuko","family":"Nomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1310-9403","authenticated-orcid":false,"given":"Ryo","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Oguma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadao","family":"Nagasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironobu","family":"Sunadome","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuyasu","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9626-1090","authenticated-orcid":false,"given":"Susumu","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Ohashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takamitsu","family":"Tsukahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7431-9044","authenticated-orcid":false,"given":"Toyohiro","family":"Hirai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2024,11,14]]},"reference":[{"key":"2025070309050797000_11.3.00841-2024.1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202301-0106PP"},{"key":"2025070309050797000_11.3.00841-2024.2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202109-2205PP"},{"key":"2025070309050797000_11.3.00841-2024.3","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1007\/s12325-020-01573-x","article-title":"Asthma and chronic obstructive pulmonary disease overlap according to the Japanese Respiratory Society diagnostic criteria: the prospective, observational ACO Japan cohort study","volume":"38","author":"Hashimoto","year":"2021","journal-title":"Adv Ther"},{"key":"2025070309050797000_11.3.00841-2024.4","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01359-2015"},{"key":"2025070309050797000_11.3.00841-2024.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2022.11.008"},{"key":"2025070309050797000_11.3.00841-2024.6","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2020-215167"},{"key":"2025070309050797000_11.3.00841-2024.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.10.011"},{"key":"2025070309050797000_11.3.00841-2024.8","doi-asserted-by":"crossref","first-page":"615959","DOI":"10.3389\/fcimb.2021.615959","article-title":"The role of neutrophils and neutrophil elastase in pneumococcal pneumonia","volume":"11","author":"Domon","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"key":"2025070309050797000_11.3.00841-2024.9","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1239151"},{"key":"2025070309050797000_11.3.00841-2024.10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2021713"},{"key":"2025070309050797000_11.3.00841-2024.11","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31767-7"},{"key":"2025070309050797000_11.3.00841-2024.12","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.2147\/COPD.S132961","article-title":"Bronchiectasis in COPD patients: more than a comorbidity?","volume":"12","author":"Martinez-Garcia","year":"2017","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"2025070309050797000_11.3.00841-2024.13","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1159\/000507228","article-title":"The link between asthma and bronchiectasis: state of the art","volume":"99","author":"Crimi","year":"2020","journal-title":"Respiration"},{"key":"2025070309050797000_11.3.00841-2024.14","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1186\/s12931-022-02289-y","article-title":"Nationwide survey of refractory asthma with bronchiectasis by inflammatory subtypes","volume":"23","author":"Nomura","year":"2022","journal-title":"Respir Res"},{"key":"2025070309050797000_11.3.00841-2024.15","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.707109"},{"key":"2025070309050797000_11.3.00841-2024.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.03.013"},{"key":"2025070309050797000_11.3.00841-2024.17","doi-asserted-by":"crossref","first-page":"e1771","DOI":"10.1002\/ctm2.1771","article-title":"Endotypes of severe neutrophilic and eosinophilic asthma from multi-omics integration of U-BIOPRED sputum samples","volume":"14","author":"Kermani","year":"2024","journal-title":"Clin Transl Med"},{"key":"2025070309050797000_11.3.00841-2024.18","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02135-2016"},{"key":"2025070309050797000_11.3.00841-2024.19","doi-asserted-by":"crossref","first-page":"1117749","DOI":"10.3389\/fimmu.2023.1117749","article-title":"IgA-producing B cells in lung homeostasis and disease","volume":"14","author":"Bertrand","year":"2023","journal-title":"Front Immunol"},{"key":"2025070309050797000_11.3.00841-2024.20","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.jaci.2016.11.049","article-title":"HMGB1 is upregulated in the airways in asthma and potentiates airway smooth muscle contraction via TLR4","volume":"140","author":"Di Candia","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"2025070309050797000_11.3.00841-2024.21","doi-asserted-by":"crossref","first-page":"100194","DOI":"10.1016\/j.jacig.2023.100194","article-title":"Sputum microbiota and inflammatory subtypes in asthma, COPD, and its overlap","volume":"3","author":"Morimoto","year":"2024","journal-title":"J Allergy Clin Immunol Glob"},{"key":"2025070309050797000_11.3.00841-2024.22","doi-asserted-by":"publisher","DOI":"10.1016\/j.resinv.2014.03.003"},{"key":"2025070309050797000_11.3.00841-2024.23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2006.00784.x"},{"key":"2025070309050797000_11.3.00841-2024.24","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1080\/09168451.2017.1383849","article-title":"A preliminary study of gut dysbiosis in children with food allergy","volume":"81","author":"Inoue","year":"2017","journal-title":"Biosci Biotechnol Biochem"},{"key":"2025070309050797000_11.3.00841-2024.25","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1111\/resp.14776","article-title":"Computed tomography mucus plugs and airway tree structure in patients with chronic obstructive pulmonary disease: associations with airflow limitation, health-related independence and mortality","volume":"29","author":"Tanabe","year":"2024","journal-title":"Respirology"},{"key":"2025070309050797000_11.3.00841-2024.26","doi-asserted-by":"crossref","first-page":"e300","DOI":"10.1016\/S2666-5247(21)00035-5","article-title":"Lung microbiome composition and bronchial epithelial gene expression in patients with COPD versus healthy individuals: a bacterial 16S rRNA gene sequencing and host transcriptomic analysis","volume":"2","author":"Ramsheh","year":"2021","journal-title":"Lancet Microbe"},{"key":"2025070309050797000_11.3.00841-2024.27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.03.044"},{"key":"2025070309050797000_11.3.00841-2024.28","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201309-1575OC"},{"key":"2025070309050797000_11.3.00841-2024.29","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0016-2018"},{"key":"2025070309050797000_11.3.00841-2024.30","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.alit.2024.05.004","article-title":"Mucus plugging on computed tomography and the sputum microbiome in patients with asthma, chronic obstructive pulmonary disease, and asthma-COPD overlap","volume":"73","author":"Tanabe","year":"2024","journal-title":"Allergol Int"},{"key":"2025070309050797000_11.3.00841-2024.31","doi-asserted-by":"publisher","DOI":"10.1172\/JCI95693"},{"key":"2025070309050797000_11.3.00841-2024.32","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2020-215986"},{"key":"2025070309050797000_11.3.00841-2024.33","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1111\/all.13760","article-title":"Inflammatory endotypes in COPD","volume":"74","author":"Barnes","year":"2019","journal-title":"Allergy"},{"key":"2025070309050797000_11.3.00841-2024.34","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.05593-11"},{"key":"2025070309050797000_11.3.00841-2024.35","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2010.00173"},{"key":"2025070309050797000_11.3.00841-2024.36","doi-asserted-by":"crossref","first-page":"e120901","DOI":"10.1172\/JCI120901","article-title":"Airway mucins promote immunopathology in virus-exacerbated chronic obstructive pulmonary disease","volume":"132","author":"Singanayagam","year":"2022","journal-title":"J Clin Invest"},{"key":"2025070309050797000_11.3.00841-2024.37","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3010525"},{"key":"2025070309050797000_11.3.00841-2024.38","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201807-485AW"},{"key":"2025070309050797000_11.3.00841-2024.39","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201104-0597OC"},{"key":"2025070309050797000_11.3.00841-2024.40","doi-asserted-by":"publisher","DOI":"10.1159\/000321374"}],"container-title":["ERJ Open Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/23120541.00841-2024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T16:05:18Z","timestamp":1751558718000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/23120541.00841-2024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,14]]},"references-count":40,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,5,19]]},"published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1183\/23120541.00841-2024"],"URL":"https:\/\/doi.org\/10.1183\/23120541.00841-2024","relation":{},"ISSN":["2312-0541"],"issn-type":[{"value":"2312-0541","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,14]]}}}