{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T21:49:28Z","timestamp":1778622568697,"version":"3.51.4"},"reference-count":39,"publisher":"European Respiratory Society (ERS)","issue":"3","license":[{"start":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T00:00:00Z","timestamp":1616716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["ERJ Open Res"],"accepted":{"date-parts":[[2021,3,13]]},"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:p>The aim of this study was to determine if there is a difference in 6-min walk test (6MWT) distance when the assessor accompanies the patient to continuously measure peripheral oxygen saturation (<jats:italic>S<\/jats:italic><jats:sub>pO<jats:sub>2<\/jats:sub><\/jats:sub>) compared to the patient walking unaccompanied.<\/jats:p><jats:p>\u2003We conducted a randomised crossover study to evaluate the impact of the assessor walking with the patient during the 6MWT (6MWT<jats:sub>with<\/jats:sub>)<jats:italic>versus<\/jats:italic>the patient walking alone (6MWT<jats:sub>without<\/jats:sub>). At the end of a pulmonary rehabilitation programme, each patient performed two 6MWTs in random order and separated by a 30-min rest.<\/jats:p><jats:p>\u200349 patients with chronic obstructive pulmonary disease (COPD) (Global Initiative for Obstructive Lung Disease classification II\u2013IV) were included. In a regression model adjusting for period and subject, accompanying the patient resulted in a lower walking distance (mean difference \u22129.1\u2005m, 95% CI \u221213.9\u2013\u2009\u22124.3, p=0.0004). Notably, six patients walked more than 30\u2005m farther (minimal important difference) in one of the two conditions (6MWT<jats:sub>with<\/jats:sub>: n=1, 6MWT<jats:sub>without<\/jats:sub>: n=5). There were no between-sequence-group differences in heart rate, dyspnoea, leg fatigue and<jats:italic>S<\/jats:italic><jats:sub>pO<jats:sub>2<\/jats:sub><\/jats:sub>. The median (interquartile range) number and duration of<jats:italic>S<\/jats:italic><jats:sub>pO<jats:sub>2<\/jats:sub><\/jats:sub>signal artefacts were high but not different between the experimental conditions (6MWT<jats:sub>with<\/jats:sub>: 17 (4\u201324), 34\u2005s (7\u2013113 s); 6\u2005MWT<jats:sub>without<\/jats:sub>: 11 (3\u201326), 24\u2005s (4\u201362 s)).<\/jats:p><jats:p>\u2003At a study population level, we observed a statistically significant difference in 6MWT distance between the two experimental conditions; however, the magnitude of difference was small and may not be clinically relevant. Nevertheless, in a clinical setting, unaccompanied walking resulted in a substantially higher walking distance in individual patients, pointing towards strictly standardised testing methodology, in particular in pre\u2013post study designs.<\/jats:p>","DOI":"10.1183\/23120541.00921-2020","type":"journal-article","created":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T18:50:21Z","timestamp":1616784621000},"page":"00921-2020","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Accompanied<i>versus<\/i>unaccompanied walking for continuous oxygen saturation measurement during 6-min walk test in COPD: a randomised crossover study"],"prefix":"10.1183","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6213-239X","authenticated-orcid":false,"given":"Thomas F.","family":"Riegler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja","family":"Frei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4704-6570","authenticated-orcid":false,"given":"Sarah R.","family":"Haile","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1723-1070","authenticated-orcid":false,"given":"Thomas","family":"Radtke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2021,3,26]]},"reference":[{"key":"2024101711081419000_7.3.00921-2020.1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00150314"},{"key":"2024101711081419000_7.3.00921-2020.2","doi-asserted-by":"publisher","DOI":"10.1183\/20734735.021314"},{"key":"2024101711081419000_7.3.00921-2020.3","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00150414"},{"key":"2024101711081419000_7.3.00921-2020.4","doi-asserted-by":"publisher","DOI":"10.1159\/000332833"},{"key":"2024101711081419000_7.3.00921-2020.5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2010.02169.x"},{"key":"2024101711081419000_7.3.00921-2020.6","doi-asserted-by":"publisher","DOI":"10.1177\/1479972311407355"},{"key":"2024101711081419000_7.3.00921-2020.7","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.02494"},{"key":"2024101711081419000_7.3.00921-2020.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2006.06.017"},{"key":"2024101711081419000_7.3.00921-2020.9","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.166.1.at1102"},{"key":"2024101711081419000_7.3.00921-2020.10","doi-asserted-by":"publisher","DOI":"10.1016\/S1836-9553(13)70181-4"},{"key":"2024101711081419000_7.3.00921-2020.11","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-2823"},{"key":"2024101711081419000_7.3.00921-2020.12","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200203-166OC"},{"key":"2024101711081419000_7.3.00921-2020.13","doi-asserted-by":"publisher","DOI":"10.1378\/chest.13-0287"},{"key":"2024101711081419000_7.3.00921-2020.14","unstructured":"Global Initiative for Chronic Obstructive Lung Disease . 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