{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T18:11:04Z","timestamp":1778004664661,"version":"3.51.4"},"reference-count":36,"publisher":"European Respiratory Society (ERS)","issue":"2","license":[{"start":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:00:00Z","timestamp":1765411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016912","name":"Merck Sharp and Dohme France","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016912","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["ERJ Open Res"],"accepted":{"date-parts":[[2025,10,9]]},"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The epidemiological, clinical and medico-economic burden of unexplained or refractory chronic cough (URCC) is poorly known.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe sociodemographic characteristics, clinical impact, healthcare resource utilisation and associated costs in French patients with URCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Populations of interest (chronic cough, URCC, controls) were identified from the general population-based Constances cohort (124\u2009565 participants at the time of study inception) and invited to answer a specific\n                      <jats:italic>ad hoc<\/jats:italic>\n                      questionnaire on cough. Their healthcare resource utilisation data were extracted from the National Healthcare Database System.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Populations of interest were identified among participants for whom data and questionnaire responses were available (n=5277): URCC (n=116), non-URCC (n=1357) and no chronic cough (reference group; n=3804). The extrapolated frequencies of chronic cough and URCC in the Constances cohort were 3.8% and 0.22%, respectively. URCC was mainly associated with gastro-oesophageal reflux disease (31.0%) and asthma\/COPD (18.3%). Depressive symptoms (Center for Epidemiological Studies Depression scale score \u226516) were significantly more frequent in patients with URCC than in controls (43.0%\n                      <jats:italic>versus<\/jats:italic>\n                      24.0%, p=0.0036). Over the previous 12\u2005months, the mean number of medical visits was higher in the URCC group than in controls (9.1\n                      <jats:italic>versus<\/jats:italic>\n                      6.0, p=0.0002). Treatment for underlying conditions of interest were also more frequent in the URCC group. Compared to controls, a 36% increase in medical visits and a four times increase in treatments of underlying conditions of interest were observed in the URCC group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>URCC is associated with an important clinical impact and high healthcare resource utilisation and associated costs. The burden of URCC is significant and remains an unmet medical need.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1183\/23120541.00964-2025","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T18:50:25Z","timestamp":1765479025000},"page":"00964-2025","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical impact and healthcare resource utilisation in patients with unexplained or refractory chronic cough: a French national population study"],"prefix":"10.1183","volume":"12","author":[{"given":"Laurent","family":"Guilleminault","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ga\u00eblle","family":"Le Moine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9167-0189","authenticated-orcid":false,"given":"Fabrice","family":"Ruiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdelkrim","family":"Ziad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6161-5880","authenticated-orcid":false,"given":"Marcel","family":"Goldberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4540-4282","authenticated-orcid":false,"given":"Marie","family":"Zins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3162-5033","authenticated-orcid":false,"given":"Nicolas","family":"Roche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2025,12,11]]},"reference":[{"key":"2026050510155397000_12.2.00964-2025.1","unstructured":"Rui P , Okeyode T. 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