{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T21:03:54Z","timestamp":1783544634595,"version":"3.55.0"},"reference-count":42,"publisher":"European Respiratory Society (ERS)","issue":"4","license":[{"start":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T00:00:00Z","timestamp":1711584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"MRC-UK Research and Innovation and the Department of Health and Social Care through the National Institute for Health Research","award":["COV0319"],"award-info":[{"award-number":["COV0319"]}]},{"name":"MRC-UK Research and Innovation and the Department of Health and Social Care through the National Institute for Health Research","award":["MR\/V027859\/1"],"award-info":[{"award-number":["MR\/V027859\/1"]}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["ERJ Open Res"],"accepted":{"date-parts":[[2024,3,6]]},"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The long-term outcomes of COVID-19 hospitalisation in individuals with pre-existing airway diseases are unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adult participants hospitalised for confirmed or clinically suspected COVID-19 and discharged between 5 March 2020 and 31 March 2021 were recruited to the Post-hospitalisation COVID-19 (PHOSP-COVID) study. Participants attended research visits at 5\u2005months and 1\u2005year post discharge. Clinical characteristics, perceived recovery, burden of symptoms and health-related quality of life (HRQoL) of individuals with pre-existing airway disease (<jats:italic>i.e.<\/jats:italic>, asthma, COPD or bronchiectasis) were compared to the non-airways group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 615 out of 2697 (22.8%) participants had a history of pre-existing airway diseases (72.0% diagnosed with asthma, 22.9% COPD and 5.1% bronchiectasis). At 1\u2005year, the airways group participants were less likely to feel fully recovered (20.4%<jats:italic>versus<\/jats:italic>33.2%, p&lt;0.001), had higher burden of anxiety (29.1%<jats:italic>versus<\/jats:italic>22.0%, p=0.002), depression (31.2%<jats:italic>versus<\/jats:italic>24.7%, p=0.006), higher percentage of impaired mobility using short physical performance battery \u226410 (57.4%<jats:italic>versus<\/jats:italic>45.2%, p&lt;0.001) and 27% had a new disability (assessed by the Washington Group Short Set on Functioning)<jats:italic>versus<\/jats:italic>16.6%, p=0.014. HRQoL assessed using EQ-5D-5L Utility Index was lower in the airways group (mean\u00b1SD 0.64\u00b10.27<jats:italic>versus<\/jats:italic>0.73\u00b10.25, p&lt;0.001). Burden of breathlessness, fatigue and cough measured using a study-specific tool was higher in the airways group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Individuals with pre-existing airway diseases hospitalised due to COVID-19 were less likely to feel fully recovered, had lower physiological performance measurements, more burden of symptoms and reduced HRQoL up to 1\u2005year post-hospital discharge.<\/jats:p><\/jats:sec>","DOI":"10.1183\/23120541.00982-2023","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T17:16:37Z","timestamp":1711646197000},"page":"00982-2023","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Long-term impact of COVID-19 hospitalisation among individuals with pre-existing airway diseases in the UK: a multicentre, longitudinal cohort study \u2013 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