{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T02:40:10Z","timestamp":1787539210650,"version":"build-2736575974"},"reference-count":35,"publisher":"European Respiratory Society (ERS)","issue":"2","license":[{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010767","name":"Innovative Medicines Initiative","doi-asserted-by":"publisher","award":["820820"],"award-info":[{"award-number":["820820"]}],"id":[{"id":"10.13039\/501100010767","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["ERJ Open Res"],"accepted":{"date-parts":[[2025,11,5]]},"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Recent advances in wearable technologies make it possible to accurately quantify real-world mobility performance through technically validated digital mobility outcomes (DMOs). The aim of the present study was to evaluate the construct validity (convergent, divergent, and known-groups validity) of 24 DMOs quantifying walking activity (amount and pattern) and gait (pace, rhythm and bout-to-bout variability) in people with COPD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Part of the Mobilise-D observational cohort study, people with COPD, recruited from seven European sites, wore an activity monitor for 7 days during daily life. Functional capacity, health status, dyspnoea, lung function, quadriceps torque and experience of difficulty with physical activity were used as constructs for convergent validity testing (Pearson\/Spearman correlation coefficients). Diastolic blood pressure was used as an unrelated construct for divergent validity (criterion: |r|&lt;0.2). Known-groups validity was evaluated across Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages (I\u2013IV), GOLD ABE and modified Medical Research Council dyspnoea grades (linear models with p-for-trend).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      549 participants (37% females), had mean\u00b1\n                      <jats:sc>sd<\/jats:sc>\n                      age of 68\u00b18 years, post-bronchodilator forced expiratory volume in 1 s (FEV\n                      <jats:sub>1<\/jats:sub>\n                      ) 54\u00b120% predicted and 6-min walk distance 416\u00b1119 m. Convergent validity was supported for the majority of DMOs (17 out of 24) with correlation coefficients meeting or exceeding the\n                      <jats:italic>a priori<\/jats:italic>\n                      hypotheses by clinical experts. All DMOs supported divergent validity. 22 out of 24 DMOs distinguished between disease severity groups successfully. Expert consensus supported construct validity of 17 DMOs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Construct validity was supported for all walking activity (amount and pattern) DMOs, and most of the gait (pace, rhythm, and bout-to-bout variability) DMOs, indicating the clinical utility of these measures.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1183\/23120541.00993-2025","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T14:16:03Z","timestamp":1770300963000},"page":"00993-2025","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["The construct validity of real-world digital mobility outcomes in people with 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