{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:50:49Z","timestamp":1793296249219,"version":"4.5.0"},"reference-count":31,"publisher":"European Respiratory Society (ERS)","issue":"3","license":[{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["ERJ Open Res"],"accepted":{"date-parts":[[2025,10,30]]},"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Bronchiectasis research has advanced significantly through international and national registries, such as the European Multicentre Bronchiectasis Audit and Research Collaboration (EMBARC) registry, revealing crucial insights into the disease's heterogeneous nature. These efforts underscore the importance of precise patient phenotyping and the identification of underlying causes to improve management and outcomes in bronchiectasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The prospective, non-interventional PROGNOSIS registry has collected data from over 1500 computed tomography-confirmed adult bronchiectasis patients across 38 German sites, excluding those with cystic fibrosis or lung transplants. Aligned with the EMBARC registry, it ensures comprehensive clinical data collection. Statistical analyses of baseline and follow-up data aims to assess disease progression and patient outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Key outcomes include a reduction in median (interquartile range (IQR)) exacerbations (2 (1\u20134) to 1 (1\u20133); p&lt;0.001) and hospitalisations (1 (1\u20132) to 1 (1\u20131); p&lt;0.001), demonstrating an improvement in managing the disease during patients\u2019 participation in the registry. Lung function (median (IQR) forced expiratory volume in 1\u2005s % pred 73% (51\u201390%) to 73% (52\u201392%); p=0.6) remained stable over time, contradicting the expected decline in such chronic lung conditions. There was a significant decrease in active smokers (4.4% to 3.6%; p&lt;0.001), and improvements were seen in sputum quantity and quality. There was an increase in the detection of pathogens, particularly\n                      <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                      (32% to 36%; p&lt;0.001). Notable shifts in the underlying causes of bronchiectasis were observed over the registry period, including a decrease in idiopathic cases (35% to 28%; p&lt;0.001) and an increase in cases with a proven aetiology.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The PROGNOSIS registry highlights the critical role of comprehensive management in bronchiectasis, emphasising infection control and treatment adherence. It underscores the need for personalised treatment by identifying the underlying aetiology and reinforces the ongoing importance of research in improving patient care and quality of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1183\/23120541.01121-2025","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T17:45:20Z","timestamp":1766079920000},"page":"01121-2025","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of German Bronchiectasis Registry participation with disease course"],"prefix":"10.1183","volume":"12","author":[{"given":"Jessica","family":"Rademacher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9084-4968","authenticated-orcid":false,"given":"Felix C.","family":"Ringshausen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sivagurunathan","family":"Sutharsan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5193-7755","authenticated-orcid":false,"given":"Gernot","family":"Rohde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annegret","family":"Zurawski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Sieber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grit","family":"Barten-Neiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Adaskina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabell","family":"Pink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5032-5941","authenticated-orcid":false,"given":"Pontus","family":"Mertsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2025,12,18]]},"reference":[{"key":"2026052601450633000_12.3.01121-2025.1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00629-2017"},{"key":"2026052601450633000_12.3.01121-2025.2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201309-1575OC"},{"key":"2026052601450633000_12.3.01121-2025.3","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s41030-024-00275-x","article-title":"Survival outcomes in US Medicare patients with non-cystic fibrosis bronchiectasis by rate of baseline exacerbations","volume":"10","author":"Feliciano","year":"2024","journal-title":"Pulm Ther"},{"key":"2026052601450633000_12.3.01121-2025.4","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.1937"},{"key":"2026052601450633000_12.3.01121-2025.5","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.2290"},{"key":"2026052601450633000_12.3.01121-2025.6","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/S2213-2600(19)30191-2","article-title":"Long-term macrolide antibiotics for the treatment of bronchiectasis in adults: an individual participant data meta-analysis","volume":"7","author":"Chalmers","year":"2019","journal-title":"Lancet Respir Med"},{"key":"2026052601450633000_12.3.01121-2025.7","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S2213-2600(23)00093-0","article-title":"Bronchiectasis in Europe: data on disease characteristics from the European Bronchiectasis registry (EMBARC)","volume":"11","author":"Chalmers","year":"2023","journal-title":"Lancet Respir Med"},{"key":"2026052601450633000_12.3.01121-2025.8","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201506-333OC"},{"key":"2026052601450633000_12.3.01121-2025.9","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.136119"},{"key":"2026052601450633000_12.3.01121-2025.10","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2014-205587"},{"key":"2026052601450633000_12.3.01121-2025.11","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201312-2208OC"},{"key":"2026052601450633000_12.3.01121-2025.12","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/S2213-2600(14)70165-1","article-title":"Aztreonam for inhalation solution in patients with non-cystic fibrosis bronchiectasis (AIR-BX1 and AIR-BX2): two randomised double-blind, placebo-controlled phase 3 trials","volume":"2","author":"Barker","year":"2014","journal-title":"Lancet Respir Med"},{"key":"2026052601450633000_12.3.01121-2025.13","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0108-2018"},{"key":"2026052601450633000_12.3.01121-2025.14","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00777-2021"},{"key":"2026052601450633000_12.3.01121-2025.15","doi-asserted-by":"crossref","first-page":"F1000 Faculty Rev-293","DOI":"10.12688\/f1000research.17295.1","article-title":"Bronchiectasis insanity: doing the same thing over and over again and expecting different results?","volume":"8","author":"Metersky","year":"2019","journal-title":"F1000Res"},{"key":"2026052601450633000_12.3.01121-2025.16","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.chest.2016.10.055","article-title":"Adult patients with bronchiectasis: a first look at the US Bronchiectasis Research Registry","volume":"151","author":"Aksamit","year":"2017","journal-title":"Chest"},{"key":"2026052601450633000_12.3.01121-2025.17","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1392254"},{"key":"2026052601450633000_12.3.01121-2025.18","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/S2213-2600(21)00277-0","article-title":"Criteria and definitions for the radiological and clinical diagnosis of bronchiectasis in adults for use in clinical trials: international consensus recommendations","volume":"10","author":"Aliberti","year":"2022","journal-title":"Lancet Respir Med"},{"key":"2026052601450633000_12.3.01121-2025.19","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201908-1590ST"},{"key":"2026052601450633000_12.3.01121-2025.20","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.165.2.7618537"},{"key":"2026052601450633000_12.3.01121-2025.21","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01269-2018"},{"key":"2026052601450633000_12.3.01121-2025.22","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1001\/jamacardio.2023.0241","article-title":"Quality of care and outcomes among patients hospitalized for heart failure in rural vs urban US hospitals: the Get With The Guidelines-Heart Failure registry","volume":"8","author":"Pierce","year":"2023","journal-title":"JAMA Cardiol"},{"key":"2026052601450633000_12.3.01121-2025.23","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-025033"},{"key":"2026052601450633000_12.3.01121-2025.24","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1186\/s13075-015-0836-6","article-title":"Higher education is associated with a better rheumatoid arthritis outcome concerning for pain and function but not disease activity: results from the EIRA cohort and Swedish rheumatology register","volume":"17","author":"Jiang","year":"2015","journal-title":"Arthritis Res Ther"},{"key":"2026052601450633000_12.3.01121-2025.25","doi-asserted-by":"crossref","first-page":"100690","DOI":"10.1016\/j.lanepe.2023.100690","article-title":"Impact of elexacaftor\/tezacaftor\/ivacaftor on lung function, nutritional status, pulmonary exacerbation frequency and sweat chloride in people with cystic fibrosis: real-world evidence from the German CF Registry","volume":"32","author":"Sutharsan","year":"2023","journal-title":"Lancet Reg Health Eur"},{"key":"2026052601450633000_12.3.01121-2025.26","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.jcf.2023.11.003","article-title":"The new face of cystic fibrosis in the era of population genetic carrier screening","volume":"23","author":"Dotan","year":"2023","journal-title":"J Cyst Fibros"},{"key":"2026052601450633000_12.3.01121-2025.27","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.chest.2024.05.023","article-title":"Primary ciliary dyskinesia in adult bronchiectasis: data from the German Bronchiectasis Registry PROGNOSIS","volume":"166","author":"Ewen","year":"2024","journal-title":"Chest"},{"key":"2026052601450633000_12.3.01121-2025.28","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00611-2022"},{"key":"2026052601450633000_12.3.01121-2025.29","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/S2213-2600(24)00364-3","article-title":"Baseline characteristics of patients in the Chinese Bronchiectasis Registry (BE-China): a multicentre prospective cohort study","volume":"13","author":"Xu","year":"2025","journal-title":"Lancet Respir Med"},{"key":"2026052601450633000_12.3.01121-2025.30","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)01867-1"},{"key":"2026052601450633000_12.3.01121-2025.31","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00499-2019"}],"container-title":["ERJ Open Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/23120541.01121-2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T08:45:14Z","timestamp":1779785114000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/23120541.01121-2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,18]]},"references-count":31,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,5,26]]},"published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1183\/23120541.01121-2025"],"URL":"https:\/\/doi.org\/10.1183\/23120541.01121-2025","relation":{},"ISSN":["2312-0541"],"issn-type":[{"value":"2312-0541","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,18]]}}}