{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T06:51:55Z","timestamp":1781765515774,"version":"3.54.5"},"reference-count":49,"publisher":"European Respiratory Society (ERS)","issue":"5","license":[{"start":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T00:00:00Z","timestamp":1743638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100030962","name":"H\u00f4pital Foch","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100030962","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["ERJ Open Res"],"accepted":{"date-parts":[[2025,3,17]]},"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Endothelial dysfunction (ED) is involved in the pathophysiology of idiopathic pulmonary fibrosis (IPF). Reactive hyperaemia peripheral arterial tonometry (RH-PAT) is a rapid, reproducible, noninvasive technique for assessing peripheral microvascular endothelial function.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a prospective study of endothelial function (reactive hyperaemia index (RHI) as measured by RH-PAT) in patients with IPF, in order to explore the association between ED and respiratory symptoms, lung function and the disease prognosis. Adult patients with IPF underwent a baseline assessment of respiratory symptoms (including dyspnoea on the modified Medical Research Council scale), blood gas levels, pulmonary function tests, a 6-min walk test (6MWT) and endothelial function. The same examinations were performed 12, 24 and 36\u2005months after inclusion.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>42 patients with IPF (men: 76%) were enrolled. The median (IQR) age was 70 (61\u201375) years. The median (IQR) forced vital capacity and diffusing capacity of the lung for carbon monoxide (<jats:italic>D<\/jats:italic>\n                     <jats:sub>LCO<\/jats:sub>) were 77% (66\u201393%) and 43% (33\u201353%) predicted, respectively. The median (IQR) RHI was 1.86 (1.60\u20132.48). An ED defined at the RHI reference cut-off of 1.67 was observed in 13 (31%) patients. After 1\u2005year of follow-up, there was a significant decline in endothelial function (median (IQR) difference: 0.65 (0.35\u20130.85), p=0.009). The RHI was associated with dyspnoea (r=\u2009\u22120.33, p=0.036), <jats:italic>D<\/jats:italic>\n                     <jats:sub>LCO<\/jats:sub> (r=0.36, p=0.025) and oxygen saturation at the end of 6MWT (r=0.33, p=0.049). The subgroups of patients with and without ED did not differ significantly in terms of mortality or the occurrence of acute exacerbations, although there was a nonsignificant trend to greater functional disease progression in patients with ED.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Finger ED was correlated with respiratory symptoms and functional variables and worsened during the first year of follow-up. Our results suggest that the severity of IPF is associated with ED, although further studies are needed to assess the value of RH-PAT in the management of IPF.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1183\/23120541.01265-2024","type":"journal-article","created":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T08:53:06Z","timestamp":1743670386000},"page":"01265-2024","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical relevance of microvascular endothelial dysfunction in idiopathic pulmonary fibrosis"],"prefix":"10.1183","volume":"11","author":[{"given":"Jean","family":"Pastr\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Salvator","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla","family":"Henno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"G\u00fcnther","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Chabrol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanislas","family":"Grassin-Delyle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Isra\u00ebl-Biet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Devillier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2025,4,3]]},"reference":[{"key":"2025102005400948000_11.5.01265-2024.1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00957-2022"},{"key":"2025102005400948000_11.5.01265-2024.2","doi-asserted-by":"crossref","first-page":"e172058","DOI":"10.1172\/JCI172058","article-title":"Beyond epithelial damage: vascular and endothelial contributions to idiopathic pulmonary fibrosis","volume":"133","author":"May","year":"2023","journal-title":"J Clin Invest"},{"key":"2025102005400948000_11.5.01265-2024.3","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-012-9306-9"},{"key":"2025102005400948000_11.5.01265-2024.4","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00060708"},{"key":"2025102005400948000_11.5.01265-2024.5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2012.04644.x"},{"key":"2025102005400948000_11.5.01265-2024.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.patbio.2014.07.006"},{"key":"2025102005400948000_11.5.01265-2024.7","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00571-2021"},{"key":"2025102005400948000_11.5.01265-2024.8","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00487-2022"},{"key":"2025102005400948000_11.5.01265-2024.9","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03603-0"},{"key":"2025102005400948000_11.5.01265-2024.10","doi-asserted-by":"crossref","first-page":"e170502","DOI":"10.1172\/JCI170502","article-title":"The vascular perspective on acute and chronic lung disease","volume":"133","author":"Borek","year":"2023","journal-title":"J Clin Invest"},{"key":"2025102005400948000_11.5.01265-2024.11","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-49545-x"},{"key":"2025102005400948000_11.5.01265-2024.12","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23158193"},{"key":"2025102005400948000_11.5.01265-2024.13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2008470"},{"key":"2025102005400948000_11.5.01265-2024.14","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1016\/S2213-2600(21)00165-X","article-title":"Inhaled treprostinil and forced vital capacity in patients with interstitial lung disease and associated pulmonary hypertension: a post-hoc analysis of the INCREASE study","volume":"9","author":"Nathan","year":"2021","journal-title":"Lancet Respir Med"},{"key":"2025102005400948000_11.5.01265-2024.15","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3283619d50"},{"key":"2025102005400948000_11.5.01265-2024.16","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.160812"},{"key":"2025102005400948000_11.5.01265-2024.17","doi-asserted-by":"crossref","first-page":"2234059","DOI":"10.1080\/08037051.2023.2234059","article-title":"The impact of age on endothelial dysfunction measured by peripheral arterial tonometry in a healthy population-based cohort: the Malm\u00f6 offspring study","volume":"32","author":"Jujic","year":"2023","journal-title":"Blood Press"},{"key":"2025102005400948000_11.5.01265-2024.18","first-page":"101049","article-title":"Flow-mediated dilation as a marker of endothelial dysfunction in pulmonary diseases: a narrative review","volume":"84","author":"Abagnale","year":"2023","journal-title":"Respir Med Res"},{"key":"2025102005400948000_11.5.01265-2024.19","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/resp.13556","article-title":"Associations between lung and endothelial function in early middle age","volume":"25","author":"Hancox","year":"2020","journal-title":"Respirology"},{"key":"2025102005400948000_11.5.01265-2024.20","first-page":"341","article-title":"Subclinical cardiovascular disease in patients with chronic obstructive pulmonary disease: a systematic review","volume":"110","author":"Ye","year":"2017","journal-title":"QJM"},{"key":"2025102005400948000_11.5.01265-2024.21","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200707-980OC"},{"key":"2025102005400948000_11.5.01265-2024.22","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(03)00094-2"},{"key":"2025102005400948000_11.5.01265-2024.23","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328362d913"},{"key":"2025102005400948000_11.5.01265-2024.24","doi-asserted-by":"publisher","DOI":"10.1002\/clc.20668"},{"key":"2025102005400948000_11.5.01265-2024.25","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X11433188"},{"key":"2025102005400948000_11.5.01265-2024.26","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.748574"},{"key":"2025102005400948000_11.5.01265-2024.27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.10.073"},{"key":"2025102005400948000_11.5.01265-2024.28","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1161\/HYPERTENSIONAHA.118.11554","article-title":"Physiological diagnostic criteria for vascular failure","volume":"72","author":"Tanaka","year":"2018","journal-title":"Hypertension"},{"key":"2025102005400948000_11.5.01265-2024.29","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2009-040GL"},{"key":"2025102005400948000_11.5.01265-2024.30","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01499-2021"},{"key":"2025102005400948000_11.5.01265-2024.31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.08.062"},{"key":"2025102005400948000_11.5.01265-2024.32","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/1346-8138.15334","article-title":"Clinical significance of endothelial vasodilatory function evaluated by EndoPAT in patients with systemic sclerosis","volume":"47","author":"Aozasa","year":"2020","journal-title":"J Dermatol"},{"key":"2025102005400948000_11.5.01265-2024.33","doi-asserted-by":"crossref","first-page":"e1913615","DOI":"10.1001\/jamanetworkopen.2019.13615","article-title":"Association of endothelial dysfunction and antiretroviral therapy in early HIV infection","volume":"2","author":"Bush","year":"2019","journal-title":"JAMA Netw Open"},{"key":"2025102005400948000_11.5.01265-2024.34","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202202-0399ST"},{"key":"2025102005400948000_11.5.01265-2024.35","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1152\/japplphysiol.00616.2020","article-title":"Assessment of macrovascular and microvascular function in aging males","volume":"130","author":"Babcock","year":"2021","journal-title":"J Appl Physiol (1985)"},{"key":"2025102005400948000_11.5.01265-2024.36","doi-asserted-by":"crossref","first-page":"674622","DOI":"10.3389\/fcvm.2021.674622","article-title":"Cigarette smoking is related to endothelial dysfunction of resistance, but not conduit arteries in the general population: results from the Gutenberg Health Study","volume":"8","author":"Hahad","year":"2021","journal-title":"Front Cardiovasc Med"},{"key":"2025102005400948000_11.5.01265-2024.37","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200709-1412OC"},{"key":"2025102005400948000_11.5.01265-2024.38","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2008.06.014"},{"key":"2025102005400948000_11.5.01265-2024.39","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2018.07.013"},{"key":"2025102005400948000_11.5.01265-2024.40","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.3390\/biomedicines10102614","article-title":"Bronchial asthma as a cardiovascular risk factor: a prospective observational study","volume":"10","author":"Kreslov\u00e1","year":"2022","journal-title":"Biomedicines"},{"key":"2025102005400948000_11.5.01265-2024.41","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.081088"},{"key":"2025102005400948000_11.5.01265-2024.42","first-page":"102","article-title":"Prediction of organ involvement in systemic sclerosis by serum biomarkers and peripheral endothelial function","volume":"36: Suppl. 113","author":"Kawashiri","year":"2018","journal-title":"Clin Exp Rheumatol"},{"key":"2025102005400948000_11.5.01265-2024.43","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.02044"},{"key":"2025102005400948000_11.5.01265-2024.44","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2014.07.003"},{"key":"2025102005400948000_11.5.01265-2024.45","doi-asserted-by":"crossref","first-page":"108757","DOI":"10.1016\/j.pharmthera.2024.108757","article-title":"Pathology of idiopathic pulmonary fibrosis with particular focus on vascular endothelium and epithelial injury and their therapeutic potential","volume":"265","author":"Lu","year":"2025","journal-title":"Pharmacol Ther"},{"key":"2025102005400948000_11.5.01265-2024.46","doi-asserted-by":"crossref","first-page":"729","DOI":"10.2459\/JCM.0000000000001502","article-title":"Endothelial function predicts 5-year adverse outcome in patients hospitalized in an emergency department chest pain unit","volume":"24","author":"Shechter","year":"2023","journal-title":"J Cardiovasc Med (Hagerstown)"},{"key":"2025102005400948000_11.5.01265-2024.47","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1093\/cvr\/cvab087","article-title":"Non-invasive peripheral vascular function, incident cardiovascular disease, and mortality in the general population","volume":"118","author":"Schnabel","year":"2022","journal-title":"Cardiovasc Res"},{"key":"2025102005400948000_11.5.01265-2024.48","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002270"},{"key":"2025102005400948000_11.5.01265-2024.49","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab309"}],"container-title":["ERJ Open Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/23120541.01265-2024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T12:40:39Z","timestamp":1760964039000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/23120541.01265-2024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,3]]},"references-count":49,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,10,20]]},"published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1183\/23120541.01265-2024"],"URL":"https:\/\/doi.org\/10.1183\/23120541.01265-2024","relation":{},"ISSN":["2312-0541"],"issn-type":[{"value":"2312-0541","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,3]]}}}