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MDR-TB cases were admitted to hospital for a median (interquartile range (IQR)) 179 (92\u2013280) days and exposed to bedaquiline for 168 (86\u2013180) days. Treatment regimens included, among others, linezolid, moxifloxacin, clofazimine and carbapenems (82.0%, 58.4%, 52.6% and 15.3% of cases, respectively).<\/jats:p><jats:p>Sputum smear and culture conversion rates in MDR-TB cases were 63.6% and 30.1%, respectively at 30\u2005days, 81.1% and 56.7%, respectively at 60\u2005days; 85.5% and 80.5%, respectively at 90\u2005days and 88.7% and 91.2%, respectively at the end of treatment. The median (IQR) time to smear and culture conversion was 34 (30\u201360) days and 60 (33\u201390) days. Out of 247 culture-confirmed MDR-TB cases completing treatment, 71.3% achieved success (62.4% cured; 8.9% completed treatment), 13.4% died, 7.3% defaulted and 7.7% failed. Bedaquiline was interrupted due to adverse events in 5.8% of cases. A single case died, having electrocardiographic abnormalities that were probably non-bedaquiline related.<\/jats:p><jats:p>Bedaquiline-containing regimens achieved high conversion and success rates under different nonexperimental conditions.<\/jats:p>","DOI":"10.1183\/13993003.00387-2017","type":"journal-article","created":{"date-parts":[[2017,5,22]],"date-time":"2017-05-22T00:10:12Z","timestamp":1495411812000},"page":"1700387","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":242,"title":["Effectiveness and safety of bedaquiline-containing regimens in the treatment of MDR- and XDR-TB: a multicentre study"],"prefix":"10.1183","volume":"49","author":[{"given":"Sergey E.","family":"Borisov","sequence":"first","affiliation":[]},{"given":"Keertan","family":"Dheda","sequence":"additional","affiliation":[]},{"given":"Martin","family":"Enwerem","sequence":"additional","affiliation":[]},{"given":"Rodolfo","family":"Romero 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