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In TBLC, pooled incidences of complications were 9.9% (95% CI 6.8\u201314.3) for significant bleeding (6.9% for centres with \u226570 TBLC), 5.6% (95% CI 3.8\u20138.2) for pneumothorax treated with a chest tube and 1.4% (95% CI 0.9\u20132.2) for acute exacerbation of ILD after TBLC. The mortality rates were 0.6% and 1.7% for TBLC and VATS, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>TBLC has a fairly good diagnostic yield, an acceptable safety profile and a lower mortality rate than VATS. The best results are obtained from more experienced centres.<\/jats:p><\/jats:sec>","DOI":"10.1183\/16000617.0280-2021","type":"journal-article","created":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T08:20:14Z","timestamp":1664958014000},"page":"210280","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":70,"title":["Diagnostic yield and safety of transbronchial lung cryobiopsy and surgical lung biopsy in interstitial lung diseases: a systematic review and meta-analysis"],"prefix":"10.1183","volume":"31","author":[{"given":"In\u00eas","family":"Rodrigues","sequence":"first","affiliation":[]},{"given":"Ricardo","family":"Est\u00eav\u00e3o Gomes","sequence":"additional","affiliation":[]},{"given":"L\u00edgia Maria","family":"Coutinho","sequence":"additional","affiliation":[]},{"given":"Maria 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