{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T23:12:54Z","timestamp":1776208374208,"version":"3.50.1"},"reference-count":33,"publisher":"European Respiratory Society (ERS)","issue":"5","license":[{"start":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T00:00:00Z","timestamp":1716422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["ERJ Open Res"],"accepted":{"date-parts":[[2024,5,13]]},"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Home mechanical ventilation (HMV) is indicated in patients with severe hypercapnic COPD. Initiation of HMV commonly occurs during an inpatient period, but there has been increasing interest for outpatient adaptation. This study aimed to evaluate the outpatient initiation and adaptation of HMV and its impact on health-related quality of life (HRQoL) in patients with severe COPD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A single-group pre-test\u2013post-test study was conducted in an outpatient ventilation clinic of a tertiary hospital in Portugal. Patients with severe COPD and symptoms of chronic respiratory failure with daytime partial pressure of carbon dioxide (<jats:italic>P<\/jats:italic><jats:sub>CO<jats:sub>2<\/jats:sub><\/jats:sub>) \u226550\u2005mmHg in a stable condition or with persistent hypercapnia \u226553\u2005mmHg &gt;14\u2005days following an exacerbation with mechanical ventilation were included. After 3\u2005months of HMV, patients completed the severe respiratory insufficiency (SRI), the S3-noninvasive ventilation (S3-NIV) and a patient experience questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>53 patients (73.6% male, median 71 (p25\u2013p75 61\u201377) years), with a median forced expiratory volume in 1\u2005s of 35 (29\u201340)% and a median baseline<jats:italic>P<\/jats:italic><jats:sub>CO<jats:sub>2<\/jats:sub><\/jats:sub>of 53.5 (51.9\u201356.5) mmHg completed the study. At 3\u2005months patients had a median HMV usage of 6.5\u2005h and decreased their<jats:italic>P<\/jats:italic><jats:sub>CO<jats:sub>2<\/jats:sub><\/jats:sub>by 6.0\u2005mmHg. After 3\u2005months, there was a significant improvement in the SRI summary scale (+5.7), above the minimal clinically import difference of five. Patients who used HMV for more than 5\u2005h had higher S3-NIV total score (6.8<jats:italic>versus<\/jats:italic>5.7, p=0.04) and S3-NIV sleep and NIV-related side effects subscore (7.1<jats:italic>versus<\/jats:italic>5.7, p=0.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings might indicate that outpatient initiation and adaptation of HMV has a positive impact in short-term HRQoL in patients with COPD and that this approach is perceived as a positive experience by the patients.<\/jats:p><\/jats:sec>","DOI":"10.1183\/23120541.00125-2024","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T15:35:19Z","timestamp":1716478519000},"page":"00125-2024","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Impact of outpatient adaptation to home mechanical ventilation on health-related quality of life in patients with COPD: the OutVent study"],"prefix":"10.1183","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8270-3687","authenticated-orcid":false,"given":"Carla","family":"Ribeiro","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1151-8791","authenticated-orcid":false,"given":"Cristina","family":"J\u00e1come","sequence":"additional","affiliation":[]},{"given":"Pedro","family":"Oliveira","sequence":"additional","affiliation":[]},{"given":"Manuel","family":"Luj\u00e1n","sequence":"additional","affiliation":[]},{"given":"Sara","family":"Conde","sequence":"additional","affiliation":[]}],"member":"81","published-online":{"date-parts":[[2024,5,23]]},"reference":[{"key":"2024101712270000000_10.5.00125-2024.1","unstructured":"GOLD . 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