{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T22:53:14Z","timestamp":1783983194119,"version":"3.55.0"},"reference-count":14,"publisher":"Informa UK Limited","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Medical Research and Opinion"],"published-print":{"date-parts":[[2007,5,1]]},"DOI":"10.1185\/030079907x182176","type":"journal-article","created":{"date-parts":[[2007,3,28]],"date-time":"2007-03-28T00:01:01Z","timestamp":1175040061000},"page":"1033-1043","source":"Crossref","is-referenced-by-count":27,"title":["Randomized, double-blind, placebo-controlled clinical trial of loperamide plus simethicone versus loperamide alone and simethicone alone in the treatment of acute diarrhea with gas-related abdominal discomfort"],"prefix":"10.1185","volume":"23","author":[{"given":"Stephen B.","family":"Hanauer","sequence":"first","affiliation":[{"name":"University of Chicago, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert L.","family":"DuPont","sequence":"additional","affiliation":[{"name":"St. Luke's Episcopal Hospital, University of Texas\u2013Houston School of Public Health, and Baylor College of Medicine, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly M.","family":"Cooper","sequence":"additional","affiliation":[{"name":"McNeil Consumer Healthcare, Fort Washington, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Laudadio","sequence":"additional","affiliation":[{"name":"McNeil Consumer Healthcare, Fort Washington, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2007,3,26]]},"reference":[{"key":"CIT0001","unstructured":"Fine KD, Schiller LR. Diarrhea. In: Snape WJ Jr, ed. Consultations in Gastroenterology. Philadelphia: WB Saunders Co. 1996:87\u201394"},{"key":"CIT0002","doi-asserted-by":"crossref","unstructured":"Manatsathit S, DuPont HL, Farthing M, et al. Guideline for the management of acute diarrhea in adults. J Gastroenterol Hepatol 2002;17(Suppl):S54\u201371","DOI":"10.1046\/j.1440-1746.17.s1.11.x"},{"key":"CIT0003","doi-asserted-by":"crossref","unstructured":"Brownlee HJ Jr. Family practitioner\u2019s guide to patient self-treatment of acute diarrhea. Am J Med 1990;88(Suppl 6A): 27\u20139S","DOI":"10.1016\/0002-9343(90)90273-G"},{"key":"CIT0004","unstructured":"Kosek M, Bern C, Guerrant RL. The global burden of diarrhoeal disease, as estimated from studies published between 1992 and 2000. Bull World Health Organ 2003;81: 197\u2013204"},{"key":"CIT0005","first-page":"1962","volume":"92","author":"DuPont HL","year":"1997","journal-title":"Guidelines on acute infectious diarrhea in adults. Am J Gastroenterol"},{"key":"CIT0006","first-page":"3280","volume":"265","author":"Lew JF","year":"1991","journal-title":"A special problem for the elderly. JAMA"},{"key":"CIT0007","doi-asserted-by":"crossref","unstructured":"Dukes GE. Over-the-counter antidiarrheal medications used for the self-treatment of acute nonspecific diarrhea. Am J Med 1990;88(Suppl 6A):24\u20136S","DOI":"10.1016\/0002-9343(90)90272-F"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2001.00993.x"},{"key":"CIT0009","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1365-2036.1987.tb00617.x","volume":"1","author":"Review Ruppin H.","year":"1987","journal-title":"Aliment Pharmacol Ther"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1001\/archfami.8.3.243"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/23.3.617"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/20.4.1057"},{"key":"CIT0013","doi-asserted-by":"crossref","unstructured":"Collett D. Modelling Survival Data in Medical Research. London: Chapman & Hall, 1994","DOI":"10.1007\/978-1-4899-3115-3"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-0987(01)00132-4"}],"container-title":["Current Medical Research and Opinion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1185\/030079907X182176","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T11:58:43Z","timestamp":1707739123000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1185\/030079907X182176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3,26]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,5,1]]}},"alternative-id":["10.1185\/030079907X182176"],"URL":"https:\/\/doi.org\/10.1185\/030079907x182176","relation":{},"ISSN":["0300-7995","1473-4877"],"issn-type":[{"value":"0300-7995","type":"print"},{"value":"1473-4877","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,3,26]]}}}