{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:56:13Z","timestamp":1790834173858,"version":"4.1.0"},"reference-count":24,"publisher":"Informa Healthcare","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Medical Research and Opinion"],"published-print":{"date-parts":[[2011,9,1]]},"DOI":"10.1185\/03007995.2011.605440","type":"journal-article","created":{"date-parts":[[2011,8,4]],"date-time":"2011-08-04T09:36:53Z","timestamp":1312450613000},"page":"1827-1834","source":"Crossref","is-referenced-by-count":14,"title":["Efficacy, safety, and pharmacokinetics of ambrisentan in Japanese adults with pulmonary arterial hypertension"],"prefix":"10.1185","volume":"27","author":[{"given":"Shunji","family":"Yoshida","sequence":"first","affiliation":[{"name":"Division of Rheumatology and Infectious Diseases, Department of Internal Medicine, Fujita Health University School of Medicine\rAichi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunio","family":"Shirato","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine, Saito Hospital\rIshinomaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryutaro","family":"Shimamura","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline KK\rTokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norie","family":"Nakahara","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline KK\rTokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Iwase","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline KK\rTokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromu","family":"Nakajima","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline KK\rTokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3197","published-online":{"date-parts":[[2011,8,4]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp297"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-115-5-343"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2003.11.026"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2000.279.5.R1701"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-114-6-464"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199306173282402"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.01.057"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.742510"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012212"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200307-957OC"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00054804"},{"key":"CIT0012","first-page":"1483","volume":"3","author":"Billman GE.","year":"2002","journal-title":"Curr Opin Investig Drugs"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.04.050"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-1028"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.07.033"},{"key":"CIT0016","first-page":"11","volume":"3","author":"Barst RJ.","year":"2007","journal-title":"Vasc Health Risk Manag"},{"key":"CIT0017","unstructured":"Gilead Sciences, Inc. Food and Drug Administration New Drug Application 22-081. Filed Dec. 18, 2006. Approved June 15, 2007. Application available at: http:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/nda\/2007\/022081s000_ClinPharmR_P8.pdf. Accessed July 12, 2010."},{"key":"CIT0018","unstructured":"Gilead Sciences, Inc. Food and Drug Administration New Drug Application 22-081. Filed Dec. 18, 2006. Approved June 15, 2007. Application available at: http:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/nda\/2007\/022081s000_PharmR_P1.pdf. Accessed July 12, 2010."},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-007-0408-z"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.13.11.1483"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1177\/0091270008315315"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2009.03384.x"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1177\/0091270008324180"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1002\/jps.21789"}],"container-title":["Current Medical Research and Opinion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1185\/03007995.2011.605440","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,6]],"date-time":"2020-09-06T20:06:57Z","timestamp":1599422817000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1185\/03007995.2011.605440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8,4]]},"references-count":24,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2011,9,1]]}},"alternative-id":["10.1185\/03007995.2011.605440"],"URL":"https:\/\/doi.org\/10.1185\/03007995.2011.605440","relation":{},"ISSN":["0300-7995","1473-4877"],"issn-type":[{"value":"0300-7995","type":"print"},{"value":"1473-4877","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8,4]]}}}