{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T11:15:45Z","timestamp":1784891745888,"version":"3.55.0"},"reference-count":104,"publisher":"Informa UK Limited","issue":"5","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Current Medical Research and Opinion"],"published-print":{"date-parts":[[2015,5,4]]},"DOI":"10.1185\/03007995.2015.1021905","type":"journal-article","created":{"date-parts":[[2015,2,20]],"date-time":"2015-02-20T05:49:19Z","timestamp":1424411359000},"page":"925-937","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":71,"title":["Presentation and complications associated with cirrhosis of the liver"],"prefix":"10.1185","volume":"31","author":[{"given":"Fred F.","family":"Poordad","sequence":"first","affiliation":[{"name":"The Texas Liver Institute, University of Texas Health Science Center, San Antonio, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2015,2,20]]},"reference":[{"key":"e_1_3_3_2_1","first-page":"1","article-title":"Deaths: final data for 2010","volume":"61","author":"Murphy SL","year":"2013","unstructured":"Murphy SL, Xu J, Kochanek KD; Division of Vital Statistics. Deaths: final data for 2010. Natl Vital Stat Rep 2013;61:1-117","journal-title":"Natl Vital Stat Rep"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.04.005"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.13805"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.03.007"},{"key":"e_1_3_3_6_1","first-page":"1353","article-title":"Cirrhosis: diagnosis, management, and prevention","volume":"84","author":"Starr SP","year":"2011","unstructured":"Starr SP, Raines D. Cirrhosis: diagnosis, management, and prevention. Am Fam Physician 2011;84:1353-9","journal-title":"Am Fam Physician"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2012.02830.x"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840070124"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00061.2009"},{"key":"e_1_3_3_10_1","first-page":"753","volume-title":"Guyton and hall textbook of medical physiology","author":"Hall JE","year":"2011","unstructured":"Hall JE. General principles of gastrointestinal function\u2014motility, nervous control, and blood circulation. In: Hall JE, editor. Guyton and hall textbook of medical physiology. 12th ed. Philadelphia, PA: Saunders, 2011:753-62","edition":"12"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i10.2555"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2013.09.006"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/537970"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1586\/egh.12.83"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21907"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/694629"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.191"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i40.14626"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.2147\/HMER.S30256"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800600817"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.287"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21563"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i9.2143"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i11.2876"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i7.1712"},{"key":"e_1_3_3_26_1","first-page":"756","article-title":"Cirrhosis and chronic liver failure: part I. Diagnosis and evaluation","volume":"74","author":"Heidelbaugh JJ","year":"2006","unstructured":"Heidelbaugh JJ, Bruderly M. Cirrhosis and chronic liver failure: part I. Diagnosis and evaluation. Am Fam Physician 2006;74:756-62","journal-title":"Am Fam Physician"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.10.040"},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.10.013"},{"key":"e_1_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840050313"},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.51"},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.09.013"},{"key":"e_1_3_3_32_1","unstructured":"Cesario KB Choure A Modha K et al. Variceal hemorrhage. Cleveland OH: Cleveland Clinic Foundation 2014. Available at: http:\/\/www.clevelandclinicmeded.com\/medicalpubs\/diseasemanagement\/hepatology\/variceal-hemorrhage\/. Accessed April 16 2014"},{"key":"e_1_3_3_33_1","first-page":"CD004544:1-68","article-title":"Banding ligation versus beta-blockers for primary prevention in oesophageal varices in adults","volume":"8","author":"Gluud LL","year":"2012","unstructured":"Gluud LL, Krag A. Banding ligation versus beta-blockers for primary prevention in oesophageal varices in adults. Cochrane Database Syst Rev 2012;8:CD004544:1-68","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_3_34_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/346705"},{"key":"e_1_3_3_35_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i37.6131"},{"key":"e_1_3_3_36_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0910102"},{"key":"e_1_3_3_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2012.03.004"},{"key":"e_1_3_3_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcma.2012.11.005"},{"key":"e_1_3_3_39_1","first-page":"1297","article-title":"Ascites in patients with cirrhosis","volume":"59","author":"Perri GA","year":"2013","unstructured":"Perri GA. Ascites in patients with cirrhosis. Can Fam Physician 2013;59:1297-9","journal-title":"Can Fam Physician"},{"key":"e_1_3_3_40_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.099580"},{"key":"e_1_3_3_41_1","unstructured":"Runyon BA. Management of adult patients with ascites due to cirrhosis: update 2012. Alexandria VA: American Association for the Study of Liver Diseases 2013. Available at: http:\/\/www.guideline.gov\/content.aspx?id=45103. Accessed May 20 2014"},{"key":"e_1_3_3_42_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v5.i5.251"},{"key":"e_1_3_3_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840190113"},{"key":"e_1_3_3_44_1","first-page":"CD004889","article-title":"TIPS versus paracentesis for cirrhotic patients with refractory ascites","volume":"18","author":"Saab S","year":"2006","unstructured":"Saab S, Nieto JM, Lewis SK, et al. TIPS versus paracentesis for cirrhotic patients with refractory ascites. Cochrane Database Syst Rev 2006;18:CD004889","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_3_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3182a115e9"},{"key":"e_1_3_3_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.12.020"},{"key":"e_1_3_3_47_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2006.056168"},{"key":"e_1_3_3_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02065533"},{"key":"e_1_3_3_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12797"},{"key":"e_1_3_3_50_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199908053410603"},{"key":"e_1_3_3_51_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.113050"},{"key":"e_1_3_3_52_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3182506dbb"},{"key":"e_1_3_3_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12070"},{"key":"e_1_3_3_54_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i14.1700"},{"key":"e_1_3_3_55_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.33160"},{"key":"e_1_3_3_56_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i36.4978"},{"key":"e_1_3_3_57_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0809139"},{"key":"e_1_3_3_58_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v5.i12.685"},{"key":"e_1_3_3_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14903-3"},{"key":"e_1_3_3_60_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e318188947c"},{"key":"e_1_3_3_61_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0b013e3283614c7a"},{"key":"e_1_3_3_62_1","first-page":"CD005162","article-title":"Terlipressin for hepatorenal syndrome","volume":"9","author":"Gluud LL","year":"2012","unstructured":"Gluud LL, Christensen K, Christensen E, et al. Terlipressin for hepatorenal syndrome. Cochrane Database Syst Rev 2012;9:CD005162","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_3_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.23485"},{"key":"e_1_3_3_64_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-0160"},{"key":"e_1_3_3_65_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i45.8252"},{"key":"e_1_3_3_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2008.02384.x"},{"key":"e_1_3_3_67_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e3283417567"},{"key":"e_1_3_3_68_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M412448200"},{"key":"e_1_3_3_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-005-5089-0"},{"key":"e_1_3_3_70_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.122176"},{"key":"e_1_3_3_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2004.02.010"},{"key":"e_1_3_3_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.05.016"},{"key":"e_1_3_3_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2012.03.009"},{"key":"e_1_3_3_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2013.07.421"},{"key":"e_1_3_3_75_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-13-107"},{"key":"e_1_3_3_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23128"},{"key":"e_1_3_3_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.413"},{"key":"e_1_3_3_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.05.017"},{"key":"e_1_3_3_79_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.30.pt2.28S"},{"key":"e_1_3_3_80_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0907893"},{"key":"e_1_3_3_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27210"},{"key":"e_1_3_3_82_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-984576"},{"key":"e_1_3_3_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03964.x"},{"key":"e_1_3_3_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2010.116"},{"key":"e_1_3_3_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.12.021"},{"key":"e_1_3_3_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12803"},{"key":"e_1_3_3_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.113"},{"key":"e_1_3_3_88_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.05.056"},{"key":"e_1_3_3_89_1","doi-asserted-by":"crossref","first-page":"22S","DOI":"10.1592\/phco.30.pt2.22S","article-title":"Factors affecting compliance and persistence with treatment for hepatic encephalopathy","volume":"30","author":"Neff G","year":"2010","unstructured":"Neff G. Factors affecting compliance and persistence with treatment for hepatic encephalopathy. Pharmacotherapy 2010;30:22S-7S","journal-title":"Pharmacotherapy"},{"key":"e_1_3_3_90_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2008.01861.x"},{"key":"e_1_3_3_91_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e3282f3e6f5"},{"key":"e_1_3_3_92_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.08.061"},{"key":"e_1_3_3_93_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756283X11413002"},{"key":"e_1_3_3_94_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI66028"},{"key":"e_1_3_3_95_1","doi-asserted-by":"crossref","unstructured":"Gagnon L Geerts L Doucet A et al. Oral treatment with PBI-4050 a novel first-in-class anti-fibrotic compound reduces hepatic fibrosis and hepatocellular carcinoma. Presented at: 2014 Annual Meeting of the European Association for the Study of the Liver; April 9-13 2014; London United Kingdom","DOI":"10.1016\/S0168-8278(14)60235-X"},{"issue":"1","key":"e_1_3_3_96_1","first-page":"221A","article-title":"Anti-fibrotic and anti-inflammatory activity of the dual CCR2 and CCR5 antagonist cenicriviroc in a mouse model of NASH","volume":"58","author":"Lefebvre E","year":"2013","unstructured":"Lefebvre E, Hashiguchi T, Jenkins H, et al. Anti-fibrotic and anti-inflammatory activity of the dual CCR2 and CCR5 antagonist cenicriviroc in a mouse model of NASH. Hepatology 2013;58(Suppl 1):221A-2A","journal-title":"Hepatology"},{"issue":"1","key":"e_1_3_3_97_1","first-page":"590A","article-title":"Vitamin D inhibits development of liver fibrosis in animal model but cannot ameliorate established cirrhosis","volume":"58","author":"Abramovitch S","year":"2013","unstructured":"Abramovitch S, Sharvit E, Weisman Y, et al. Vitamin D inhibits development of liver fibrosis in animal model but cannot ameliorate established cirrhosis. Hepatology 2013;58(Suppl 1):590A","journal-title":"Hepatology"},{"issue":"1","key":"e_1_3_3_98_1","first-page":"502A","article-title":"Coffee and liver disease: evidence of beneficial effects in experimental non-alcoholic steatohepatitis and of direct antifibrotic properties of caffeine in vitro","volume":"58","author":"Oyarzun JE","year":"2013","unstructured":"Oyarzun JE, Tiebosch M, Quintero P, et al. Coffee and liver disease: evidence of beneficial effects in experimental non-alcoholic steatohepatitis and of direct antifibrotic properties of caffeine in vitro. Hepatology 2013;58(Suppl 1):502A","journal-title":"Hepatology"},{"key":"e_1_3_3_99_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-008-0553-z"},{"key":"e_1_3_3_100_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-014-0142-5"},{"key":"e_1_3_3_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(14)60070-2"},{"key":"e_1_3_3_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2011.06.013"},{"issue":"2","key":"e_1_3_3_103_1","first-page":"231","article-title":"Pathophysiology of portal hypertension","volume":"59","author":"Cichoz-Lach H","year":"2008","unstructured":"Cichoz-Lach H, Celinski K, Slomka M, et al. Pathophysiology of portal hypertension. J Physiol Pharmacol 2008;59(Suppl 2):231-8","journal-title":"J Physiol Pharmacol"},{"key":"e_1_3_3_104_1","doi-asserted-by":"publisher","DOI":"10.4161\/gmic.29599"},{"key":"e_1_3_3_105_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i45.16795"}],"container-title":["Current Medical Research and Opinion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1185\/03007995.2015.1021905","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T20:09:03Z","timestamp":1770408543000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1185\/03007995.2015.1021905"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,20]]},"references-count":104,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5,4]]}},"alternative-id":["10.1185\/03007995.2015.1021905"],"URL":"https:\/\/doi.org\/10.1185\/03007995.2015.1021905","relation":{},"ISSN":["0300-7995","1473-4877"],"issn-type":[{"value":"0300-7995","type":"print"},{"value":"1473-4877","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,20]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=icmo20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=icmo20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2015-02-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-02-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}