{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:14:28Z","timestamp":1792700068455,"version":"4.5.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["biol res"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1186\/0717-6287-47-32","type":"journal-article","created":{"date-parts":[[2014,7,10]],"date-time":"2014-07-10T21:09:12Z","timestamp":1405026552000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["In vivo and in vitro anti-inflammatory activity of Cryptostegia grandiflora Roxb. ex R. Br. leaves"],"prefix":"10.1186","volume":"47","author":[{"given":"Jenny P","family":"Castro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanet C","family":"Ocampo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis A","family":"Franco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,7,10]]},"reference":[{"key":"32_CR1","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1093\/qjmed\/hcq148","volume":"103","author":"H Conroy","year":"2010","unstructured":"Conroy H, Mawhinney L, Donnelly S: Inflammation and cancer: macrophage migration inhibitory factor (MIF)\u2014the potential missing link. QJM 2010, 103: 831-836.","journal-title":"QJM"},{"key":"32_CR2","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1530\/REP-11-0069","volume":"142","author":"JL Hutchinson","year":"2011","unstructured":"Hutchinson JL, Rajagopal SP, Sales KJ, Jabbour HN: Molecular regulators of resolution of inflammation: potential therapeutic targets in the reproductive system. Reproduction 2011, 142: 15-28.","journal-title":"Reproduction"},{"key":"32_CR3","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.pneurobio.2010.04.004","volume":"91","author":"RC Shelton","year":"2010","unstructured":"Shelton RC, Miller AH: Eating ourselves to death (and despair): the contribution of adiposity and inflammation to depression. Prog Neurobiol 2010, 91: 275-299.","journal-title":"Prog Neurobiol"},{"key":"32_CR4","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1177\/0022034510378683","volume":"90","author":"D Bayarsaihan","year":"2011","unstructured":"Bayarsaihan D: Epigenetic mechanisms in inflammation. J Dent Res 2011, 90: 9-17.","journal-title":"J Dent Res"},{"key":"32_CR5","doi-asserted-by":"publisher","first-page":"365","DOI":"10.5603\/FHC.2011.0052","volume":"49","author":"K Kowal","year":"2011","unstructured":"Kowal K, Silver R, S\u0142awi\u0144ska E, Bielecki M, Chyczewski L, Kowal-Bielecka O: CD163 and its role in inflammation. Folia Histochem Cytobiol 2011, 49: 365-364.","journal-title":"Folia Histochem Cytobiol"},{"key":"32_CR6","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.phrs.2005.12.010","volume":"53","author":"A Mustafa","year":"2006","unstructured":"Mustafa A, El-Medany A, Hagar HH, El-Medany G: Ginkgo biloba attenuates mucosal damage in a rat model of ulcerative colitis. Pharmacol Res 2006, 53: 324-330.","journal-title":"Pharmacol Res"},{"key":"32_CR7","first-page":"111","volume":"11","author":"Z Amirghofran","year":"2012","unstructured":"Amirghofran Z: Herbal Medicines for Immunosuppression. Iran J Allergy Asthma Immunol 2012, 11: 111-119.","journal-title":"Iran J Allergy Asthma Immunol"},{"key":"32_CR8","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/S0378-8741(03)00280-0","volume":"89","author":"EM Choi","year":"2003","unstructured":"Choi EM, Hwang JK: Investigations of anti-inflammatory and antinociceptive activities of Piper cubeba , Physalis angulata and Rosa hybrida . J Ethnopharmacol 2003, 89: 171-175.","journal-title":"J Ethnopharmacol"},{"key":"32_CR9","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.fct.2011.10.043","volume":"50","author":"AQ Khan","year":"2012","unstructured":"Khan AQ, Khan R, Qamar W, Lateef A, Ali F, Tahir M, Muneeb UR, Sultana S: Caffeic acid attenuates 12- O -tetradecanoyl-phorbol-13-acetate (TPA)-induced NF-\u03baB and COX-2 expression in mouse skin: abrogation of oxidative stress, inflammatory responses and proinflammatory cytokine production. Food Chem Toxicol 2012, 50: 175-183.","journal-title":"Food Chem Toxicol"},{"key":"32_CR10","doi-asserted-by":"publisher","first-page":"110","DOI":"10.7705\/biomedica.v27i1.237","volume":"27","author":"LA Franco","year":"2007","unstructured":"Franco LA, Matiz GE, Calle J, Pinz\u00f3n R, Ospina LF: Antiinflammatory activity of extracts and fractions obtained from Physalis peruviana L. calyces. Biomedica 2007, 27: 110-115.","journal-title":"Biomedica"},{"key":"32_CR11","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/S0926-6690(99)00036-9","volume":"11","author":"G Augustus","year":"2000","unstructured":"Augustus G, Jayabalan M, Seiler G: Cryptostegia grandiflora -a potential multi-use crop. Ind Crop Prod 2000, 11: 59-62.","journal-title":"Ind Crop Prod"},{"key":"32_CR12","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.toxicon.2008.10.009","volume":"53","author":"TM Albuquerque","year":"2009","unstructured":"Albuquerque TM, Alencar N, Figueiredo JG, Figueiredo IS, Teixeira CM, Bitencourt FS, Secco DD, Ara\u00fajo ES, Ana Maria Le\u00e3o C, Ramos MV: Vascular permeability, neutrophil migration and edematogenic effects induced by the latex of Cryptostegia grandiflora . Toxicon 2009, 53: 15-23.","journal-title":"Toxicon"},{"key":"32_CR13","volume-title":"Estimation of phytoconstituents from Cryptostegia grandiflora (Roxb.) R. Br. in vivo and in vitro. II. Antimicrobial screening","author":"B Singh","year":"2011","unstructured":"Singh B, Sharma RA, Vyas GK, Sharma P: Estimation of phytoconstituents from Cryptostegia grandiflora (Roxb.) R. Br. in vivo and in vitro. II. Antimicrobial screening. 2011."},{"key":"32_CR14","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1002\/(SICI)1099-1573(199902)13:1<70::AID-PTR377>3.0.CO;2-V","volume":"13","author":"PK Mukherjee","year":"1999","unstructured":"Mukherjee PK, Gunasekhran R, Subburaju T, Dhanbal SP, Duraiswamy B, Vijayan P, Suresh B: Studies on the antibacterial potential of Cryptostegia grandiflora R. Br. (Asclepiadaceae) extract. Phytother Res 1999, 13: 70-72.","journal-title":"Phytother Res"},{"key":"32_CR15","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/0378-8741(90)90051-T","volume":"29","author":"N Nagaraju","year":"1990","unstructured":"Nagaraju N, Rao KN: A survey of plant crude drugs of rayalaseema, Andhra Pradesh, India. J Ethnopharmacol 1990, 29: 137-158.","journal-title":"J Ethnopharmacol"},{"key":"32_CR16","first-page":"367","volume":"10","author":"S Ray","year":"2011","unstructured":"Ray S, Sheikh M, Mishra S: Ethnomedicnal plants used by tribals of east Nimar region, Madhya Pradesh. Ind J Tradnl Knowledge 2011, 10: 367-371.","journal-title":"Ind J Tradnl Knowledge"},{"key":"32_CR17","first-page":"24","volume":"120","author":"P Vijayan","year":"2004","unstructured":"Vijayan P, Raghu C, Ashok G, Dhanaraj S, Suresh B: Antiviral activity of medicinal plants of Nilgiris. Indian J Med Res 2004, 120: 24.","journal-title":"Indian J Med Res"},{"key":"32_CR18","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1016\/j.phymed.2010.01.006","volume":"17","author":"N Pinto","year":"2010","unstructured":"Pinto N, Morais T, Carvalho K, Silva C, Andrade G, Brito G, Veras M, Pessoa O, Rao V, Santos F: Topical anti-inflammatory potential of Physalin E from Physalis angulata on experimental dermatitis in mice. Phytomedicine 2010, 17: 740-743.","journal-title":"Phytomedicine"},{"key":"32_CR19","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1016\/j.bcp.2006.01.005","volume":"71","author":"M Murakawa","year":"2006","unstructured":"Murakawa M, Yamaoka K, Tanaka Y, Fukuda Y: Involvement of tumor necrosis factor (TNF)-\u03b1 in phorbol ester 12- O -tetradecanoylphorbol-13-acetate (TPA)-induced skin edema in mice. Biochem Pharmacol 2006, 71: 1331-1336.","journal-title":"Biochem Pharmacol"},{"key":"32_CR20","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.pharmthera.2005.06.023","volume":"111","author":"D Lau","year":"2006","unstructured":"Lau D, Baldus S: Myeloperoxidase and its contributory role in inflammatory vascular disease. Pharmacol Ther 2006, 111: 16-26.","journal-title":"Pharmacol Ther"},{"key":"32_CR21","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1089\/jmf.2012.0102","volume":"15","author":"FV Silva","year":"2012","unstructured":"Silva FV, Guimaraes AG, Silva ER, Sousa-Neto BP, Machado FD, Quintans-Junior LJ, Arcanjo DD, Oliveira FA, Oliveira RC: Anti-inflammatory and anti-ulcer activities of carvacrol, a monoterpene present in the essential oil of oregano. J Med Food 2012, 15: 984-991.","journal-title":"J Med Food"},{"key":"32_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2012\/438912","volume":"2012","author":"H Uzkeser","year":"2012","unstructured":"Uzkeser H, Cadirci E, Halici Z, Odabasoglu F, Polat B, Yuksel TN, Ozaltin S, Atalay F: Anti-Inflammatory and Antinociceptive Effects of Salbutamol on Acute and Chronic Models of Inflammation in Rats: Involvement of an Antioxidant Mechanism. Mediat Inflamm 2012, 2012: 1-10.","journal-title":"Mediat Inflamm"},{"key":"32_CR23","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.phymed.2003.12.011","volume":"12","author":"R Lantz","year":"2005","unstructured":"Lantz R, Chen G, Solyom A, Jolad S, Timmermann B: The effect of turmeric extracts on inflammatory mediator production. Phytomedicine 2005, 12: 445-452.","journal-title":"Phytomedicine"},{"key":"32_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4161\/viru.3.1.18844","volume":"3","author":"DO Schairer","year":"2012","unstructured":"Schairer DO, Chouake JS, Nosanchuk JD, Friedman AJ: The potential of nitric oxide releasing therapies as antimicrobial agents. Virulence 2012, 3: 1.","journal-title":"Virulence"},{"key":"32_CR25","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/S0223-5234(01)01197-7","volume":"36","author":"G Dannhardt","year":"2001","unstructured":"Dannhardt G, Kiefer W: Cyclooxygenase inhibitors\u2013current status and future prospects. Eur J Med Chem 2001, 36: 109-126.","journal-title":"Eur J Med Chem"},{"key":"32_CR26","doi-asserted-by":"publisher","first-page":"263","DOI":"10.4155\/tde.11.151","volume":"3","author":"J Han","year":"2012","unstructured":"Han J, Shuvaev VV, Muzykantov VR: Targeted interception of signaling reactive oxygen species in the vascular endothelium. Ther Deliv 2012, 3: 263-276.","journal-title":"Ther Deliv"},{"key":"32_CR27","doi-asserted-by":"publisher","first-page":"S494","DOI":"10.1016\/S2222-1808(12)60209-6","volume":"1","author":"SK Hanumanthappa","year":"2012","unstructured":"Hanumanthappa SK, Hanumanthappa M, Venkatarangaiah K, Krishnappa P, Gupta RKP: Analgesic activity of Cryptostegia grandiflora (Roxb.) R.br. leaves methanol extract using mice. Asian Pacific J Tropical Dis 2Supplement 2012, 1: S494-S498.","journal-title":"Asian Pacific J Tropical Dis 2Supplement"},{"key":"32_CR28","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1007\/s00011-009-0037-3","volume":"58","author":"A Garc\u00eda-Lafuente","year":"2009","unstructured":"Garc\u00eda-Lafuente A, Guillam\u00f3n E, Villares A, Rostagno M, Mart\u00ednez J: Flavonoids as anti-inflammatory agents: implications in cancer and cardiovascular disease. Inflamm Res 2009, 58: 537-552.","journal-title":"Inflamm Res"},{"key":"32_CR29","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1002\/ptr.3428","volume":"25","author":"VL Kumar","year":"2011","unstructured":"Kumar VL, Chaudhary P, Ramos MV, Mohan M, Matos MP: Protective Effect of Proteins Derived from the Latex of Calotropis procera against Inflammatory Hyperalgesia in Monoarthritic Rats. Phytother Res 2011, 25: 1336-1341.","journal-title":"Phytother Res"},{"key":"32_CR30","first-page":"335","volume":"26","author":"LM De Young","year":"1989","unstructured":"De Young LM, Kheifets JB, Ballaron SJ, Young JM: Edema and cell infiltration in the phorbol ester-treated mouse ear are temporally separate and can be differentially modulated by pharmacologic agents. Inflamm Res 1989, 26: 335-341.","journal-title":"Inflamm Res"},{"key":"32_CR31","doi-asserted-by":"publisher","first-page":"271","DOI":"10.2340\/00015555-1046","volume":"91","author":"L Langer Lilleholt","year":"2011","unstructured":"Langer Lilleholt L, Johansen C, Arthur JSC, Funding A, Bibby BM, Kragballe K, Iversen L: Role of p38 mitogen-activated protein kinase isoforms in murine skin inflammation induced by 12- O -tetradecanoylphorbol 13-acetate. Acta Derm Venereol 2011, 91: 271-278.","journal-title":"Acta Derm Venereol"},{"key":"32_CR32","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1111\/1523-1747.ep12506462","volume":"78","author":"PP Bradley","year":"1982","unstructured":"Bradley PP, Priebat DA, Christensen RD, Rothstein G: Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J Investig Dermatol 1982, 78: 206-209.","journal-title":"J Investig Dermatol"},{"key":"32_CR33","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","volume":"65","author":"T Mosmann","year":"1983","unstructured":"Mosmann T: Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods 1983, 65: 55-63.","journal-title":"J Immunol Methods"},{"key":"32_CR34","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/0022-1759(90)90187-Z","volume":"131","author":"M Ferrari","year":"1990","unstructured":"Ferrari M, Fornasiero MC, Isetta AM: MTT colorimetric assay for testing macrophage cytotoxic activity in vitro. J Immunol Methods 1990, 131: 165-172.","journal-title":"J Immunol Methods"},{"key":"32_CR35","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/0003-2697(82)90118-X","volume":"126","author":"LC Green","year":"1982","unstructured":"Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR: Analysis of nitrate, nitrite, and nitrate in biological fluids. Anal Biochem 1982, 126: 131-138.","journal-title":"Anal Biochem"},{"key":"32_CR36","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1111\/j.2042-7158.1997.tb06761.x","volume":"49","author":"RMNA Sreejayan","year":"1997","unstructured":"Sreejayan RMNA: Nitric Oxide Scavenging by Curcuminoids. J Pharm Pharmacol 1997, 49: 105-107.","journal-title":"J Pharm Pharmacol"},{"key":"32_CR37","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.foodchem.2005.03.032","volume":"97","author":"A Kumaran","year":"2006","unstructured":"Kumaran A, Joel KR: Antioxidant and free radical scavenging activity of an aqueous extract of Coleus aromaticus . Food Chem 2006, 97: 109-114.","journal-title":"Food Chem"},{"key":"32_CR38","doi-asserted-by":"publisher","first-page":"4705","DOI":"10.1021\/jf040057v","volume":"52","author":"BM Silva","year":"2004","unstructured":"Silva BM, Andrade PB, Valent\u00e3o P, Ferreres F, Seabra RM, Ferreira MA: Quince ( Cydonia oblonga Miller) fruit (pulp, peel, and seed) and jam: antioxidant activity. J Agric Food Chem 2004, 52: 4705-4712.","journal-title":"J Agric Food Chem"},{"key":"32_CR39","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1016\/S0891-5849(98)00315-3","volume":"26","author":"R Re","year":"1999","unstructured":"Re R, Pellegrini N, Proteggente A, Pannala A, Yang M, Rice-Evans C: Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic Biol Med 1999, 26: 1231-1237.","journal-title":"Free Radic Biol Med"}],"container-title":["Biological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/0717-6287-47-32.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T04:54:09Z","timestamp":1630558449000},"score":1,"resource":{"primary":{"URL":"https:\/\/biolres.biomedcentral.com\/articles\/10.1186\/0717-6287-47-32"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,10]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["32"],"URL":"https:\/\/doi.org\/10.1186\/0717-6287-47-32","relation":{},"ISSN":["0717-6287"],"issn-type":[{"value":"0717-6287","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,10]]},"assertion":[{"value":"24 June 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 July 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"32"}}