{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T09:12:39Z","timestamp":1705914759963},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,5,29]],"date-time":"2013-05-29T00:00:00Z","timestamp":1369785600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Headache Pain"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Migraine with aura is a complex neurological disorder modeled in animals by cortical spreading depression. It is less usual to find complete animal models for the disease so any opportunity to test a human effect back at the bench is welcome.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Findings<\/jats:title>\n            <jats:p>We report the case of a 24\u00a0year old woman who developed new onset episodic migraine with visual aura shortly after treatment initiation with the I<jats:italic>f<\/jats:italic> ion channel blocker ivabradine for frequency control in hypertrophic cardiomyopathy. We studied whether ivabradine could alter cortical spreading depression in a suitable animal model. Sixteen rats received either ivabradine or saline, and the number of depolarization shifts and blood flow changes induced by cortical spreading depression were measured in both groups. No significant differences between the ivabradine and saline group were detected.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Ivabradine is an interesting substance since it is known to produce migraine-like phosphenes frequently and the patient we report developed <jats:italic>de novo<\/jats:italic> migraine with aura. However, we were unable to demonstrate that the drug influences the susceptibility of the brain to cortical spreading depression with acute administration. The combined data show the relationship of migraine aura to cortical spreading depression may have some nuances yet to be identified.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1129-2377-14-45","type":"journal-article","created":{"date-parts":[[2013,5,29]],"date-time":"2013-05-29T12:14:52Z","timestamp":1369829692000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["New onset migraine with aura after treatment initiation with ivabradine"],"prefix":"10.1186","volume":"14","author":[{"given":"Till","family":"Sprenger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weera","family":"Supronsinchai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J","family":"Goadsby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,5,29]]},"reference":[{"key":"293_CR1","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/1741-7015-7-71","volume":"7","author":"T Sprenger","year":"2009","unstructured":"Sprenger T, Goadsby PJ: Migraine pathogenesis and state of pharmacological treatment options. BMC Med 2009, 7: 71.","journal-title":"BMC Med"},{"issue":"Suppl 1","key":"293_CR2","first-page":"1","volume":"24","author":"Headache Classification Committee of The International Headache Society","year":"2004","unstructured":"Headache Classification Committee of The International Headache Society: The International Classification of Headache Disorders (second edition). Cephalalgia 2004,24(Suppl 1):1\u2013160.","journal-title":"Cephalalgia"},{"key":"293_CR3","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1093\/brain\/119.2.355","volume":"119","author":"MB Russell","year":"1996","unstructured":"Russell MB, Olesen J: A nosographic analysis of the migraine aura in a general population. Brain 1996, 119: 355\u2013361.","journal-title":"Brain"},{"key":"293_CR4","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1093\/brain\/117.1.199","volume":"117","author":"M Lauritzen","year":"1994","unstructured":"Lauritzen M: Pathophysiology of the migraine aura. The spreading depression theory. Brain 1994, 117: 199\u2013210.","journal-title":"Brain"},{"key":"293_CR5","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1159\/000095430","volume":"43","author":"I Savelieva","year":"2006","unstructured":"Savelieva I, Camm AJ: Novel If current inhibitor ivabradine: safety considerations. Adv Cardiol 2006, 43: 79\u201396.","journal-title":"Adv Cardiol"},{"key":"293_CR6","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1146\/annurev.physiol.65.092101.142734","volume":"65","author":"RB Robinson","year":"2003","unstructured":"Robinson RB, Siegelbaum SA: Hyperpolarization-activated cation currents: from molecules to physiological function. 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Br J Pharmacol 2007, 150: 383\u2013390.","journal-title":"Br J Pharmacol"},{"key":"293_CR9","doi-asserted-by":"publisher","DOI":"10.1159\/isbn.978-3-318-01381-8","volume-title":"Heart Rate Slowing by If Current Inhibition","author":"AJ Camm","year":"2006","unstructured":"Camm AJ, Tendera M: Heart Rate Slowing by If Current Inhibition. Basel: Karger; 2006."},{"key":"293_CR10","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1002\/ana.20778","volume":"59","author":"C Ayata","year":"2006","unstructured":"Ayata C, Jin H, Kudo C, Dalkara T, Moskowitz MA: Suppression of cortical spreading depression in migraine prophylaxis. Ann Neurol 2006, 59: 652\u201361.","journal-title":"Ann Neurol"},{"key":"293_CR11","first-page":"1383","volume":"16","author":"S Akerman","year":"2005","unstructured":"Akerman S, Goadsby PJ: Topiramate inhibits cortical spreading depression in rat and cat: impact in migraine aura. Neuro Report 2005, 16: 1383\u20131387.","journal-title":"Neuro Report"},{"key":"293_CR12","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1002\/ana.23653","volume":"72","author":"PR Holland","year":"2012","unstructured":"Holland PR, Akerman S, Andreou AP, Karsan N, Wemmie JA, Goadsby PJ: Acid-sensing ion channel-1: a novel therapeutic target for migraine with aura. 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