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This study aims at assessing if cephalalgiaphobia is related to migraine frequency or medication overuse, and if it is per se a predictor of increase in migraine frequency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a pilot prospective cohort study on 126 consecutive migraineurs referred to a tertiary Headache Centre. A headache specialist collected data regarding migraine features, frequency and medications at baseline (T0) and 2\u00a0years later (T1). Cephalalgiaphobia was investigated at T0 and T1 through a score determined by a 4 items questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Moderate-high migraine frequency was associated with higher risk of cephalalgiaphobia (p\u2009&lt;\u20090.001). Chronic migraineurs with medication overuse had higher score of cephalalgiaphobia than those without medication overuse (p\u2009&lt;\u20090.001). Patients with increased migraine frequency between T0 and T1 had higher cephalalgiaphobia score (p\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cephalalgiaphobia may represent a high-frequency migraine feature and may play a role in chronicization. Therefore, it should be better investigated by clinicians and treated or prevented in order to reduce the risk of disability and the increase in migraine frequency.<\/jats:p><\/jats:sec>","DOI":"10.1186\/1129-2377-14-49","type":"journal-article","created":{"date-parts":[[2013,6,10]],"date-time":"2013-06-10T10:14:35Z","timestamp":1370859275000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Cephalalgiaphobia as a feature of high-frequency migraine: a pilot study"],"prefix":"10.1186","volume":"14","author":[{"given":"Giulia","family":"Giannini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Zanigni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Grimaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Melotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Pierangeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Cortelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabina","family":"Cevoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,6,10]]},"reference":[{"issue":"Suppl 1","key":"294_CR1","doi-asserted-by":"publisher","first-page":"S61","DOI":"10.1007\/s10072-009-0071-5","volume":"30","author":"SM Baskin","year":"2009","unstructured":"Baskin SM, Smitherman TA: Migraine and psychiatric disorders: comorbidities, mechanism, and clinical applications. 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