{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:26:32Z","timestamp":1792718792005,"version":"4.5.0"},"reference-count":206,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,7,23]],"date-time":"2013-07-23T00:00:00Z","timestamp":1374537600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Headache Pain"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Spreading depression (SD) is a slowly propagating wave of neuronal and glial depolarization lasting a few minutes, that can develop within the cerebral cortex or other brain areas after electrical, mechanical or chemical depolarizing stimulations. Cortical SD (CSD) is considered the neurophysiological correlate of migraine aura. It is characterized by massive increases in both extracellular K<jats:sup>+<\/jats:sup>and glutamate, as well as rises in intracellular Na<jats:sup>+<\/jats:sup>and Ca<jats:sup>2+<\/jats:sup>. These ionic shifts produce slow direct current (DC) potential shifts that can be recorded extracellularly. Moreover, CSD is associated with changes in cortical parenchymal blood flow.<\/jats:p><jats:p>CSD has been shown to be a common therapeutic target for currently prescribed migraine prophylactic drugs. Yet, no effects have been observed for the antiepileptic drugs carbamazepine and oxcarbazepine, consistent with their lack of efficacy on migraine. Some molecules of interest for migraine have been tested for their effect on CSD. Specifically, blocking CSD may play an enabling role for novel benzopyran derivative tonabersat in preventing migraine with aura. Additionally, calcitonin gene-related peptide (CGRP) antagonists have been recently reported to inhibit CSD, suggesting the contribution of CGRP receptor activation to the initiation and maintenance of CSD not only at the classic vascular sites, but also at a central neuronal level. Understanding what may be lying behind this contribution, would add further insights into the mechanisms of actions for \u201cgepants\u201d, which may be pivotal for the effectiveness of these drugs as anti-migraine agents.<\/jats:p><jats:p>CSD models are useful tools for testing current and novel prophylactic drugs, providing knowledge on mechanisms of action relevant for migraine.<\/jats:p>","DOI":"10.1186\/1129-2377-14-62","type":"journal-article","created":{"date-parts":[[2013,7,24]],"date-time":"2013-07-24T12:40:43Z","timestamp":1374669643000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":140,"title":["Cortical spreading depression as a target for anti-migraine agents"],"prefix":"10.1186","volume":"14","author":[{"given":"Cinzia","family":"Costa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Tozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Innocenzo","family":"Rainero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letizia Maria","family":"Cupini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Calabresi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cenk","family":"Ayata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Sarchielli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,7,23]]},"reference":[{"key":"306_CR1","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1152\/classicessays.00031.2005","volume":"94","author":"GG Somjen","year":"2005","unstructured":"Somjen GG: Aristides Le\u00e3o's discovery of cortical spreading depression. J Neurophysiol 2005, 94: 2\u20134. 10.1152\/classicessays.00031.2005","journal-title":"J Neurophysiol"},{"key":"306_CR2","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1093\/brain\/awh716","volume":"129","author":"M Fabricius","year":"2006","unstructured":"Fabricius M, Fuhr S, Bhatia R, Boutelle M, Hashemi P, Strong AJ, Lauritzen M: Cortical spreading depression and peri-infarct depolarization in acutely injured human cerebral cortex. Brain 2006, 129: 778\u2013790. 10.1093\/brain\/awh716","journal-title":"Brain"},{"key":"306_CR3","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/jcbfm.2010.191","volume":"31","author":"M Lauritzen","year":"2011","unstructured":"Lauritzen M, Dreier JP, Fabricius M, Hartings JA, Graf R, Strong AJ: Clinical relevance of cortical spreading depression in neurological disorders: migraine, malignant stroke, subarachnoid and intracranial hemorrhage, and traumatic brain injury. J Cereb Blood Flow Metab 2011, 31: 17\u201335. 10.1038\/jcbfm.2010.191","journal-title":"J Cereb Blood Flow Metab"},{"key":"306_CR4","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1038\/nm.2333","volume":"17","author":"JP Dreier","year":"2011","unstructured":"Dreier JP: The role of spreading depression, spreading depolarization and spreading ischemia in neurological disease. Nat Med 2011, 17: 439\u2013447. 10.1038\/nm.2333","journal-title":"Nat Med"},{"key":"306_CR5","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1152\/physrev.2001.81.3.1065","volume":"81","author":"GG Somjen","year":"2001","unstructured":"Somjen GG: Mechanisms of spreading depression and hypoxic spreading depression-like depolarization. Physiol Rev 2001, 81: 1065\u20131096.","journal-title":"Physiol Rev"},{"key":"306_CR6","series-title":"Austria vol","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/3-211-27208-9_1","volume-title":"Advances and Technical Standards in Neurosurgery, Springer, Wien, vol 30","author":"AJ Strong","year":"2005","unstructured":"Strong AJ, Dardis R: Depolarisation phenomena in traumatic and ischaemic brain injury. Austria vol. In Advances and Technical Standards in Neurosurgery, Springer, Wien, vol 30 Edited by: Pickard JD. 2005, 3\u201349."},{"key":"306_CR7","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1046\/j.1526-4610.1997.3710622.x","volume":"37","author":"HC Diener","year":"1997","unstructured":"Diener HC: Positron emission tomography studies in headache. Headache 1997, 37: 622\u2013625. 10.1046\/j.1526-4610.1997.3710622.x","journal-title":"Headache"},{"key":"306_CR8","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1111\/j.1468-2982.2009.02015.x","volume":"30","author":"PC Tfelt-Hansen","year":"2010","unstructured":"Tfelt-Hansen PC: History of migraine with aura and cortical spreading depression from 1941 and onwards. Cephalalgia 2010, 30: 780\u2013792.","journal-title":"Cephalalgia"},{"key":"306_CR9","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/S1474-4422(04)00904-4","volume":"3","author":"M S\u00e1nchez del Rio","year":"2004","unstructured":"S\u00e1nchez del Rio M, Alvarez Linera J: Functional neuroimaging of headaches. Lancet Neurol 2004, 3: 645\u2013651. 10.1016\/S1474-4422(04)00904-4","journal-title":"Lancet Neurol"},{"key":"306_CR10","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1017\/S1464793106007081","volume":"81","author":"JM Smith","year":"2006","unstructured":"Smith JM, Bradley DP, James MF, Huang CL: Physiological studies of cortical spreading depression. Biol Rev Camb Philos Soc 2006, 81: 457\u2013481. 10.1017\/S1464793106007081","journal-title":"Biol Rev Camb Philos Soc"},{"key":"306_CR11","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1586\/14737175.8.5.759","volume":"8","author":"JM Smith","year":"2008","unstructured":"Smith JM, James MF, Fraser JA, Huang CL: Translational imaging studies of cortical spreading depression in experimental models for migraine aura. Expert Rev Neurother 2008, 8: 759\u2013768. 10.1586\/14737175.8.5.759","journal-title":"Expert Rev Neurother"},{"key":"306_CR12","doi-asserted-by":"publisher","first-page":"8807","DOI":"10.1523\/JNEUROSCI.0511-10.2010","volume":"30","author":"X Zhang","year":"2010","unstructured":"Zhang X, Levy D, Noseda R, Kainz V, Jakubowski M, Burstein R: Activation of meningeal nociceptors by cortical spreading depression: implications for migraine with aura. J Neurosci 2010, 30: 8807\u20138814. 10.1523\/JNEUROSCI.0511-10.2010","journal-title":"J Neurosci"},{"key":"306_CR13","first-page":"B4183","volume":"57","author":"JM Hansen","year":"2010","unstructured":"Hansen JM: Familial hemiplegic migraine. Dan Med Bull 2010, 57: B4183.","journal-title":"Dan Med Bull"},{"key":"306_CR14","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1111\/j.1526-4610.2011.01903.x","volume":"51","author":"H Bolay","year":"2011","unstructured":"Bolay H, Berman NE, Akcali D: Sex-related differences in animal models of migraine headache. Headache 2011, 51: 891\u2013904. 10.1111\/j.1526-4610.2011.01903.x","journal-title":"Headache"},{"issue":"Suppl 2","key":"306_CR15","doi-asserted-by":"crossref","first-page":"S79","DOI":"10.1111\/j.1526-4610.2007.00818.x","volume":"47","author":"K Eikermann-Haerter","year":"2007","unstructured":"Eikermann-Haerter K, Kudo C, Moskowitz MA: Cortical spreading depression and estrogen. Headache 2007,47(Suppl 2):S79-S85.","journal-title":"Headache"},{"key":"306_CR16","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1007\/s11910-010-0099-1","volume":"10","author":"K Eikermann-Haerter","year":"2010","unstructured":"Eikermann-Haerter K, Ayata C: Cortical spreading depression and migraine. Curr Neurol Neurosci Rep 2010, 10: 167\u2013173. 10.1007\/s11910-010-0099-1","journal-title":"Curr Neurol Neurosci Rep"},{"key":"306_CR17","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1586\/ern.12.13","volume":"12","author":"K Eikermann-Haerter","year":"2012","unstructured":"Eikermann-Haerter K, Can A, Ayata C: Pharmacological targeting of spreading depression in migraine. Expert Rev Neurother 2012, 12: 297\u2013306. 10.1586\/ern.12.13","journal-title":"Expert Rev Neurother"},{"key":"306_CR18","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1111\/head.12038","volume":"53","author":"KR Merikangas","year":"2013","unstructured":"Merikangas KR: Contributions of epidemiology to our understanding of migraine. Headache 2013, 53: 230\u2013246. 10.1111\/head.12038","journal-title":"Headache"},{"issue":"1","key":"306_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1468-2982.2004.00711.x","volume":"24","author":"Headache Classification Committee of The International Headache Society","year":"2004","unstructured":"Headache Classification Committee of The International Headache Society: The International Classification of Headache Disorders: 2nd edition. Cephalalgia 2004,24(1):1\u2013160. 10.1111\/j.1468-2982.2004.00711.x","journal-title":"Cephalalgia"},{"key":"306_CR20","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1586\/14737175.8.9.1321","volume":"8","author":"P Montagna","year":"2008","unstructured":"Montagna P: Migraine genetics. Expert Rev Neurother 2008, 8: 1321\u20131330. 10.1586\/14737175.8.9.1321","journal-title":"Expert Rev Neurother"},{"key":"306_CR21","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.nurt.2007.01.008","volume":"4","author":"D Pietrobon","year":"2007","unstructured":"Pietrobon D: Familial hemiplegic migraine. Neurotherapeutics 2007, 4: 274\u2013284. 10.1016\/j.nurt.2007.01.008","journal-title":"Neurotherapeutics"},{"key":"306_CR22","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1001\/archneurpsyc.1941.02280200137007","volume":"46","author":"KS Lashley","year":"1941","unstructured":"Lashley KS: Patterns of cerebral integration indicated by the scotomas of migraine. Arch Neurol Psychiatry 1941, 46: 331\u2013339. 10.1001\/archneurpsyc.1941.02280200137007","journal-title":"Arch Neurol Psychiatry"},{"key":"306_CR23","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1152\/jn.1944.7.6.359","volume":"7","author":"AAP Le\u00e3o","year":"1944","unstructured":"Le\u00e3o AAP: Spreading depression of activity in the cerebral cortex. J Neurophysiol 1944, 7: 359\u2013390.","journal-title":"J Neurophysiol"},{"key":"306_CR24","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1152\/jn.1944.7.6.391","volume":"7","author":"AAP Le\u00e3o","year":"1944","unstructured":"Le\u00e3o AAP: Pial circulation and spreading depression of activity in the cerebral cortex. J Neurophysiol 1944, 7: 391\u2013396.","journal-title":"J Neurophysiol"},{"key":"306_CR25","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1152\/jn.1947.10.6.409","volume":"10","author":"AAP Le\u00e3o","year":"1947","unstructured":"Le\u00e3o AAP: Further observations on the spreading depression of activity in the cerebral cortex. J Neurophysiol 1947, 10: 409\u2013414.","journal-title":"J Neurophysiol"},{"key":"306_CR26","first-page":"641","volume":"8","author":"HG Wolff","year":"1948","unstructured":"Wolff HG: Headache mechanisms. Bull U S Army Med Dep 1948, 8: 641\u2013653.","journal-title":"Bull U S Army Med Dep"},{"key":"306_CR27","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1002\/ana.410090406","volume":"9","author":"J Olesen","year":"1981","unstructured":"Olesen J, Larsen B, Lauritzen M: Focal hyperemia followed by spreading oligemia and impaired activation of rCBF in classic migraine. Ann Neurol 1981, 9: 344\u2013352. 10.1002\/ana.410090406","journal-title":"Ann Neurol"},{"key":"306_CR28","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1093\/brain\/117.1.199","volume":"117","author":"M Lauritzen","year":"1994","unstructured":"Lauritzen M: Pathophysiology of the migraine aura. The spreading depression theory. Brain 1994, 117: 199\u2013210. 10.1093\/brain\/117.1.199","journal-title":"Brain"},{"key":"306_CR29","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1002\/ana.410280610","volume":"28","author":"J Olesen","year":"1990","unstructured":"Olesen J, Friberg L, Olsen TS, Iversen HK, Lassen NA, Andersen AR, Karle A: Timing and topography of cerebral blood flow, aura, and headache during migraine attacks. Ann Neurol 1990, 28: 791\u2013798. 10.1002\/ana.410280610","journal-title":"Ann Neurol"},{"key":"306_CR30","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1002\/ana.410430108","volume":"43","author":"FM Cutrer","year":"1998","unstructured":"Cutrer FM, Sorensen AG, Weisskoff RM, Ostergaard L, Sanchez del Rio M, Lee EJ, Rosen BR, Moskowitz MA: Perfusion-weighted imaging defects during spontaneous migrainous aura. Ann Neurol 1998, 43: 25\u201331. 10.1002\/ana.410430108","journal-title":"Ann Neurol"},{"issue":"Suppl 2","key":"306_CR31","first-page":"S36","volume":"55","author":"FM Cutrer","year":"2000","unstructured":"Cutrer FM, O'Donnell A, Sanchez del Rio M: Functional neuroimaging: enhanced understanding of migraine pathophysiology. Neurology 2000,55(Suppl 2):S36-S45.","journal-title":"Neurology"},{"key":"306_CR32","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1001\/archneur.56.5.548","volume":"56","author":"Y Cao","year":"1999","unstructured":"Cao Y, Welch KM, Aurora S, Vikingstad EM: Functional MRI-BOLD of visually triggered headache in patients with migraine. Arch Neurol 1999, 56: 548\u2013554. 10.1001\/archneur.56.5.548","journal-title":"Arch Neurol"},{"key":"306_CR33","doi-asserted-by":"publisher","first-page":"4687","DOI":"10.1073\/pnas.071582498","volume":"98","author":"N Hadjikhani","year":"2001","unstructured":"Hadjikhani N, Sanchez Del Rio M, Wu O, Schwartz D, Bakker D, Fischl B, Kwong KK, Cutrer FM, Rosen BR, Tootell RB, Sorensen AG, Moskowitz MA: Mechanisms of migraine aura revealed by functional MRI in human visual cortex. Proc Natl Acad Sci USA 2001, 98: 4687\u20134692. 10.1073\/pnas.071582498","journal-title":"Proc Natl Acad Sci USA"},{"key":"306_CR34","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1111\/j.1468-2982.2003.00706.x","volume":"24","author":"S Oberndorfer","year":"2004","unstructured":"Oberndorfer S, W\u00f6ber C, Nasel C, Asenbaum S, Lahrmann H, Fueger B, Grisold W: Familial hemiplegic migraine: follow-up findings of diffusion-weighted magnetic resonance imaging (MRI), perfusion-MRI and [99mTc] HMPAO-SPECT in a patient with prolonged hemiplegic aura. Cephalalgia 2004, 24: 533\u2013539. 10.1111\/j.1468-2982.2003.00706.x","journal-title":"Cephalalgia"},{"key":"306_CR35","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1111\/j.1468-2982.2004.00858.x","volume":"25","author":"HR J\u00e4ger","year":"2005","unstructured":"J\u00e4ger HR, Giffin NJ, Goadsby PJ: Diffusion- and perfusion-weighted MR imaging in persistent migrainous visual disturbances. Cephalalgia 2005, 25: 323\u2013332. 10.1111\/j.1468-2982.2004.00858.x","journal-title":"Cephalalgia"},{"key":"306_CR36","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1111\/j.1526-4610.2010.01672.x","volume":"50","author":"R Belv\u00eds","year":"2010","unstructured":"Belv\u00eds R, Ramos R, Villa C, Segura C, Pagonabarraga J, Ormazabal I, Kulisevsky J: Brain apparent water diffusion coefficient magnetic resonance image during a prolonged visual aura. Headache 2010, 50: 1045\u20131049. 10.1111\/j.1526-4610.2010.01672.x","journal-title":"Headache"},{"key":"306_CR37","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/s00234-011-0946-z","volume":"54","author":"I Mourand","year":"2012","unstructured":"Mourand I, Menjot de Champfleur N, Carra-Dalli\u00e8re C, Le Bars E, Roubertie A, Bonaf\u00e9 A, Thouvenot E: Perfusion-weighted MR imaging in persistent hemiplegic migraine. Neuroradiology 2012, 54: 255\u2013260. 10.1007\/s00234-011-0946-z","journal-title":"Neuroradiology"},{"key":"306_CR38","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1111\/j.1526-4610.2008.01183.x","volume":"48","author":"D Bereczki","year":"2008","unstructured":"Bereczki D, Koll\u00e1r J, Koz\u00e1k N, Viszokay K, Barta Z, Sikula J, Magyar MT: Cortical spreading edema in persistent visual migraine aura. Headache 2008, 48: 1226\u20131229. 10.1111\/j.1526-4610.2008.01183.x","journal-title":"Headache"},{"key":"306_CR39","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1212\/WNL.58.8.1308-a","volume":"58","author":"M Smith","year":"2002","unstructured":"Smith M, Cros D, Sheen V: Hyperperfusion with vasogenic leakage by fMRI in migraine with prolonged aura. Neurology 2002, 58: 1308\u20131310.","journal-title":"Neurology"},{"key":"306_CR40","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1046\/j.1468-2982.1998.1809644.x","volume":"18","author":"G Arnold","year":"1998","unstructured":"Arnold G, Reuter U, Kinze S, Wolf T, Einh\u00e4upl KM: MWA shows gadolinium enhancement which is reversed following prophylactic treatment. Cephalalgia 1998, 18: 644\u2013646. 10.1046\/j.1468-2982.1998.1809644.x","journal-title":"Cephalalgia"},{"key":"306_CR41","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1002\/ana.1293","volume":"50","author":"SM Bowyer","year":"2001","unstructured":"Bowyer SM, Aurora KS, Moran JE, Tepley N, Welch KM: Magnetoencephalographic fields from patients with spontaneous and induced migraine aura. Ann Neurol 2001, 50: 582\u2013587. 10.1002\/ana.1293","journal-title":"Ann Neurol"},{"key":"306_CR42","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1111\/j.1526-4610.2004.04048.x","volume":"44","author":"SD Hall","year":"2004","unstructured":"Hall SD, Barnes GR, Hillebrand A, Furlong PL, Singh KD, Holliday IE: Spatio-temporal imaging of cortical desynchronization in migraine visual aura: a magnetoencephalography case study. Headache 2004, 44: 204\u2013208. 10.1111\/j.1526-4610.2004.04048.x","journal-title":"Headache"},{"key":"306_CR43","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1152\/jn.1956.19.2.154","volume":"19","author":"B Grafstein","year":"1956","unstructured":"Grafstein B: Mechanism of spreading cortical depression. J Neurophysiol 1956, 19: 154\u2013171.","journal-title":"J Neurophysiol"},{"key":"306_CR44","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1152\/classicessays.00032.2005","volume":"94","author":"AJ Strong","year":"2005","unstructured":"Strong AJ: Dr. Bernice Grafstein's paper on the mechanism of spreading depression. J Neurophysiol 2005, 94: 5\u20137. 10.1152\/classicessays.00032.2005","journal-title":"J Neurophysiol"},{"key":"306_CR45","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/S0165-0173(99)00083-1","volume":"32","author":"H Martins-Ferreira","year":"2000","unstructured":"Martins-Ferreira H, Nedergaard M, Nicholson C: Perspectives on spreading depression. Brain Res Brain Res Rev 2000, 32: 215\u2013234. 10.1016\/S0165-0173(99)00083-1","journal-title":"Brain Res Brain Res Rev"},{"key":"306_CR46","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/BF00999905","volume":"6","author":"FA de Azeredo","year":"1991","unstructured":"de Azeredo FA: Transient changes in energy metabolites and intracellular pH during spreading depression in the chick retina. Metab Brain Dis 1991, 6: 75\u201382. 10.1007\/BF00999905","journal-title":"Metab Brain Dis"},{"key":"306_CR47","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/0006-8993(94)91835-X","volume":"641","author":"LM Gault","year":"1994","unstructured":"Gault LM, Lin CW, LaManna JC, Lust WD: Changes in energy metabolites, cGMP and intracellular pH during cortical spreading depression. Brain Res 1994, 641: 176\u2013180. 10.1016\/0006-8993(94)91835-X","journal-title":"Brain Res"},{"key":"306_CR48","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/S0006-8993(97)01359-0","volume":"781","author":"DR Footitt","year":"1998","unstructured":"Footitt DR, Newberry NR: Cortical spreading depression induces an LTP-like effect in rat neocortex in vitro. Brain Res 1998, 781: 339\u2013342. 10.1016\/S0006-8993(97)01359-0","journal-title":"Brain Res"},{"key":"306_CR49","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/S0006-8993(01)02196-5","volume":"898","author":"I Vil\u00e1gi","year":"2001","unstructured":"Vil\u00e1gi I, Klapka N, Luhmann HJ: Optical recording of spreading depression in rat neocortical slices. Brain Res 2001, 898: 288\u2013296. 10.1016\/S0006-8993(01)02196-5","journal-title":"Brain Res"},{"key":"306_CR50","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1124\/jpet.106.117101","volume":"321","author":"M Peeters","year":"2007","unstructured":"Peeters M, Gunthorpe MJ, Strijbos PJ, Goldsmith P, Upton N, James MF: Effects of pan- and subtype-selective N-methyl-D-aspartate receptor antagonists on cortical spreading depression in the rat: therapeutic potential for migraine. J Pharmacol Exp Ther 2007, 321: 564\u2013572. 10.1124\/jpet.106.117101","journal-title":"J Pharmacol Exp Ther"},{"key":"306_CR51","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1161\/STROKEAHA.107.500710","volume":"39","author":"GC Petzold","year":"2008","unstructured":"Petzold GC, Haack S, von Bohlen Und Halbach O, Priller J, Lehmann TN, Heinemann U, Dirnagl U, Dreier JP: Nitric oxide modulates spreading depolarization threshold in the human and rodent cortex. Stroke 2008, 39: 1292\u20131299. 10.1161\/STROKEAHA.107.500710","journal-title":"Stroke"},{"key":"306_CR52","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1017\/S0317167100041688","volume":"19","author":"RS McLachlan","year":"1992","unstructured":"McLachlan RS: Suppression of spreading depression of Leao in neocortex by an N-methyl-D-aspartate receptor antagonist. Can J Neurol Sci 1992, 19: 487\u2013491.","journal-title":"Can J Neurol Sci"},{"key":"306_CR53","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1111\/j.1476-5381.1996.tb15283.x","volume":"117","author":"TP Obrenovitch","year":"1996","unstructured":"Obrenovitch TP, Zilkha E: Inhibition of cortical spreading depression by L-701,324, a novel antagonist at the glycine site of the N-methyl-D-aspartate receptor complex. Br J Pharmacol 1996, 117: 931\u2013937. 10.1111\/j.1476-5381.1996.tb15283.x","journal-title":"Br J Pharmacol"},{"key":"306_CR54","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/0006-8993(93)90376-X","volume":"604","author":"APG Jing","year":"1993","unstructured":"Jing APG, Somjen GG: Role of calcium channels in spreading depression in rat hippocampal slices. Brain Res 1993, 604: 251\u2013259. 10.1016\/0006-8993(93)90376-X","journal-title":"Brain Res"},{"key":"306_CR55","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/S0006-8993(97)01359-0","volume":"781","author":"DR Footitt","year":"1998","unstructured":"Footitt DR, Newberry NR: Cortical spreading depression induces an LTP-like effect in rat neocortex in vitro. Brain 1998, 781: 339\u2013342. 10.1016\/S0006-8993(97)01359-0","journal-title":"Brain"},{"key":"306_CR56","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/0006-8993(87)91652-0","volume":"437","author":"J Hern\u00e1nd\u00e9z-C\u00e1ceres","year":"1987","unstructured":"Hern\u00e1nd\u00e9z-C\u00e1ceres J, Macias-Gonz\u00e1lez R, Brozek G, Bures J: Systemic ketamine blocks cortical spreading depression but does not delay the onset of terminal anoxic depolarization in rats. Brain Res 1987, 437: 360\u2013364. 10.1016\/0006-8993(87)91652-0","journal-title":"Brain Res"},{"key":"306_CR57","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/0006-8993(88)90690-7","volume":"457","author":"R Marrannes","year":"1988","unstructured":"Marrannes R, Willems R, De Prins E, Wauquier A: Evidence for a role of the N-methyl-D-aspartate (NMDA) receptor in cortical spreading depression in the rat. Brain Res 1988, 457: 226\u2013240. 10.1016\/0006-8993(88)90690-7","journal-title":"Brain Res"},{"key":"306_CR58","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1038\/jcbfm.1992.32","volume":"12","author":"M Lauritzen","year":"1992","unstructured":"Lauritzen M, Hansen AJ: The effect of glutamate receptor blockade on anoxic depolarization and cortical spreading depression. J Cereb Blood Flow Metab 1992, 12: 223\u2013229. 10.1038\/jcbfm.1992.32","journal-title":"J Cereb Blood Flow Metab"},{"key":"306_CR59","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1111\/j.1748-1716.1992.tb09451.x","volume":"146","author":"B Nellg\u00e5rd","year":"1992","unstructured":"Nellg\u00e5rd B, Wieloch T: NMDA-receptor blockers but not NBQX, an AMPA-receptor antagonist, inhibit spreading depression in the rat brain. Acta Physiol Scand 1992, 146: 497\u2013503. 10.1111\/j.1748-1716.1992.tb09451.x","journal-title":"Acta Physiol Scand"},{"key":"306_CR60","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/S0006-8993(01)02557-4","volume":"906","author":"A Gorji","year":"2001","unstructured":"Gorji A, Scheller D, Straub H, Tegtmeier F, K\u00f6hling R, H\u00f6hling JM, Tuxhorn I, Ebner A, Wolf P, Werner Panneck H, Oppel F, Speckmann EJ: Spreading depression in human neocortical slices. Brain Res 2001, 906: 74\u201383. 10.1016\/S0006-8993(01)02557-4","journal-title":"Brain Res"},{"key":"306_CR61","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1111\/j.1468-2982.2008.01556.x","volume":"28","author":"M Berger","year":"2008","unstructured":"Berger M, Speckmann EJ, Pape HC, Gorji A: Spreading depression enhances human neocortical excitability in vitro. Cephalalgia 2008, 28: 558\u2013562. 10.1111\/j.1468-2982.2008.01556.x","journal-title":"Cephalalgia"},{"key":"306_CR62","doi-asserted-by":"publisher","first-page":"110","DOI":"10.4161\/chan.5.2.14149","volume":"5","author":"A Tottene","year":"2011","unstructured":"Tottene A, Urbani A, Pietrobon D: Role of different voltage-gated Ca2+ channels in cortical spreading depression: specific requirement of P\/Q-type Ca2+ channels. Channels (Austin) 2011, 5: 110\u2013114. 10.4161\/chan.5.2.14149","journal-title":"Channels (Austin)"},{"key":"306_CR63","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.brainres.2005.09.048","volume":"1063","author":"GC Petzold","year":"2005","unstructured":"Petzold GC, Scheibe F, Braun JS, Freyer D, Priller J, Dirnagl U, Dreier JP: Nitric oxide modulates calcium entry through P\/Q-type calcium channels and N-methyl-d-aspartate receptors in rat cortical neurons. Brain Res 2005, 1063: 9\u201314. 10.1016\/j.brainres.2005.09.048","journal-title":"Brain Res"},{"key":"306_CR64","doi-asserted-by":"publisher","first-page":"2614","DOI":"10.1093\/cercor\/bhq018","volume":"20","author":"N Zhou","year":"2010","unstructured":"Zhou N, Gordon GR, Feighan D, MacVicar BA: Transient swelling, acidification, and mitochondrial depolarization occurs in neurons but not astrocytes during spreading depression. Cereb Cortex 2010, 20: 2614\u20132624. 10.1093\/cercor\/bhq018","journal-title":"Cereb Cortex"},{"key":"306_CR65","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/0006-8993(93)91412-L","volume":"610","author":"O Herreras","year":"1993","unstructured":"Herreras O, Somjen GG: Analysis of potential shifts associated with recurrent spreading depression and prolonged unstable SD induced by microdyalisis of elevated K+ in hippocampus of anesthetized rats. Brain Res 1993, 610: 283\u2013294. 10.1016\/0006-8993(93)91412-L","journal-title":"Brain Res"},{"key":"306_CR66","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/S0304-3940(02)01120-5","volume":"334","author":"F Richter","year":"2002","unstructured":"Richter F, Ebersberger A, Schaible HG: Blockade of voltage-gated calcium channels in rat inhibits repetitive cortical spreading depression. Neurosci Lett 2002, 334: 123\u2013126. 10.1016\/S0304-3940(02)01120-5","journal-title":"Neurosci Lett"},{"issue":"4","key":"306_CR67","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1152\/jn.1975.38.4.822","volume":"38","author":"E Sugaya","year":"1975","unstructured":"Sugaya E, Takato M, Noda Y: Neuronal and glial activity during spreading depression in cerebral cortex of cat. J Neurophysiol 1975,38(4):822\u2013841.","journal-title":"J Neurophysiol"},{"key":"306_CR68","doi-asserted-by":"publisher","first-page":"109","DOI":"10.3109\/00207458108985795","volume":"12","author":"HC Tuckwell","year":"1981","unstructured":"Tuckwell HC, Hermansen CL: Ion and transmitter movements during spreading cortical depression. Int J Neurosci 1981, 12: 109\u2013135. 10.3109\/00207458108985795","journal-title":"Int J Neurosci"},{"issue":"4","key":"306_CR69","first-page":"495","volume":"56","author":"GG Somjen","year":"1984","unstructured":"Somjen GG, Aitken PG: The ionic and metabolic responses associated with neuronal depression of Le\u00e3o's type in cerebral cortex and in hippocampal formation. An Acad Bras Cienc 1984,56(4):495\u2013504.","journal-title":"An Acad Bras Cienc"},{"key":"306_CR70","doi-asserted-by":"publisher","first-page":"18985","DOI":"10.1073\/pnas.1215435109","volume":"109","author":"A Tozzi","year":"2012","unstructured":"Tozzi A, de Iure A, Di Filippo M, Costa C, Caproni S, Pisani A, Bonsi P, Picconi B, Cupini LM, Materazzi S, Geppetti P, Sarchielli P, Calabresi P: Critical role of calcitonin gene-related peptide receptors in cortical spreading depression. Proc Natl Acad Sci USA 2012, 109: 18985\u201318990. 10.1073\/pnas.1215435109","journal-title":"Proc Natl Acad Sci USA"},{"key":"306_CR71","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.brainres.2008.07.014","volume":"1229","author":"S Akerman","year":"2008","unstructured":"Akerman S, Holland PR, Goadsby PJ: Mechanically-induced cortical spreading depression associated regional cerebral blood flow changes are blocked by Na+ ion channel blockade. Brain Res 2008, 1229: 27\u201336.","journal-title":"Brain Res"},{"key":"306_CR72","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/S0006-8993(00)02233-2","volume":"869","author":"JI Addae","year":"2000","unstructured":"Addae JI, Evans SM, Ali N, Stone TW: NMDA-induced changes in a cortical network in vivo are prevented by AMPA. Brain Res 2000, 869: 211\u2013215. 10.1016\/S0006-8993(00)02233-2","journal-title":"Brain Res"},{"key":"306_CR73","doi-asserted-by":"publisher","first-page":"2713","DOI":"10.1152\/jn.00321.2002","volume":"88","author":"TR Anderson","year":"2002","unstructured":"Anderson TR, Andrew RD: Spreading depression: imaging and blockade in the rat neocortical brain slice. J Neurophysiol 2002, 88: 2713\u20132725. 10.1152\/jn.00321.2002","journal-title":"J Neurophysiol"},{"key":"306_CR74","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.ejphar.2010.11.021","volume":"653","author":"JI Addae","year":"2011","unstructured":"Addae JI, Ali N, Stone TW: Effects of AMPA and clomethiazole on spreading depression cycles in the rat neocortex in vivo. Eur J Pharmacol 2011, 653: 41\u201346. 10.1016\/j.ejphar.2010.11.021","journal-title":"Eur J Pharmacol"},{"key":"306_CR75","first-page":"519","volume":"30","author":"PR Holland","year":"2010","unstructured":"Holland PR, Akerman S, Goadsby PJ: Cortical spreading depression-associated cerebral blood flow changes induced by mechanical stimulation are modulated by AMPA and GABA receptors. Cephalalgia 2010, 30: 519\u2013527.","journal-title":"Cephalalgia"},{"key":"306_CR76","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1016\/j.neuroscience.2009.07.067","volume":"163","author":"H Haghir","year":"2009","unstructured":"Haghir H, Kovac S, Speckmann EJ, Zilles K, Gorji A: Patterns of neurotransmitter receptor distributions following cortical spreading depression. Neuroscience 2009, 163: 1340\u20131352. 10.1016\/j.neuroscience.2009.07.067","journal-title":"Neuroscience"},{"key":"306_CR77","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1152\/ajplegacy.1957.189.1.159","volume":"189","author":"A Van Harreveld","year":"1957","unstructured":"Van Harreveld A, Ochs S: Electrical and vascular concomitants of spreading depression. Am J Physiol 1957, 189: 159\u2013166.","journal-title":"Am J Physiol"},{"key":"306_CR78","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/0006-8993(87)90682-2","volume":"411","author":"M Wahl","year":"1987","unstructured":"Wahl M, Lauritzen M, Schilling L: Change of cerebrovascular reactivity after cortical spreading depression in cats and rats. Brain Res 1987, 411: 72\u201380. 10.1016\/0006-8993(87)90682-2","journal-title":"Brain Res"},{"key":"306_CR79","first-page":"H23","volume":"269","author":"M Fabricius","year":"1995","unstructured":"Fabricius M, Akgoren N, Lauritzen M: Arginine-nitric oxide pathway and cerebrovascular regulation in cortical spreading depression. Am J Physiol 1995, 269: H23-H29.","journal-title":"Am J Physiol"},{"key":"306_CR80","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1038\/jcbfm.1991.18","volume":"11","author":"RB Duckrow","year":"1991","unstructured":"Duckrow RB: Regional cerebral blood flow during spreading cortical depression in conscious rats. J Cereb Blood Flow Metab 1991, 11: 150\u2013154. 10.1038\/jcbfm.1991.18","journal-title":"J Cereb Blood Flow Metab"},{"key":"306_CR81","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/0006-8993(93)91265-T","volume":"618","author":"RB Duckrow","year":"1993","unstructured":"Duckrow RB: A brief hypoperfusion precedes spreading depression if nitric oxide synthesis is inhibited. Brain Res 1993, 618: 190\u2013195. 10.1016\/0006-8993(93)91265-T","journal-title":"Brain Res"},{"key":"306_CR82","first-page":"H96","volume":"261","author":"RD Piper","year":"1991","unstructured":"Piper RD, Lambert GA, Duckworth JW: Cortical blood flow changes during spreading depression in cats. Am J Physiol 1991, 261: H96-H102.","journal-title":"Am J Physiol"},{"key":"306_CR83","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1002\/ana.410120510","volume":"12","author":"M Lauritzen","year":"1982","unstructured":"Lauritzen M, J\u00f8rgensen MB, Diemer NH, Gjedde A, Hansen AJ: Persistent oligemia of rat cerebral cortex in the wake of spreading depression. Ann Neurol 1982, 12: 469\u2013474. 10.1002\/ana.410120510","journal-title":"Ann Neurol"},{"key":"306_CR84","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/0006-8993(92)91353-G","volume":"588","author":"PJ Goadsby","year":"1992","unstructured":"Goadsby PJ: The oligemic phase of cortical spreading depression is not blocked by tirilazad mesylate (U-74006F). Brain Res 1992, 588: 140\u2013143. 10.1016\/0006-8993(92)91353-G","journal-title":"Brain Res"},{"key":"306_CR85","doi-asserted-by":"publisher","first-page":"2726","DOI":"10.1152\/jn.00729.2001","volume":"88","author":"AM Ba","year":"2002","unstructured":"Ba AM, Guiou M, Pouratian N, Muthialu A, Rex DE, Cannestra AF, Chen JW, Toga AW: Multiwavelength optical intrinsic signal imaging of cortical spreading depression. J Neurophysiol 2002, 88: 2726\u20132735. 10.1152\/jn.00729.2001","journal-title":"J Neurophysiol"},{"issue":"1","key":"306_CR86","doi-asserted-by":"publisher","first-page":"11004","DOI":"10.1117\/1.1852556","volume":"10","author":"M Guiou","year":"2005","unstructured":"Guiou M, Sheth S, Nemoto M, Walker M, Pouratian N, Ba A, Toga AW: Cortical spreading depression produces long-term disruption of activity-related changes in cerebral blood volume and neurovascular coupling. J Biomed Opt 2005,10(1):11004. 10.1117\/1.1852556","journal-title":"J Biomed Opt"},{"key":"306_CR87","doi-asserted-by":"publisher","first-page":"2121","DOI":"10.1097\/00001756-200007140-00013","volume":"11","author":"AM O'Farrell","year":"2000","unstructured":"O'Farrell AM, Rex DE, Muthialu A, Pouratian N, Wong GK, Cannestra AF, Chen JW, Toga AW: Characterization of optical intrinsic signals and blood volume during cortical spreading depression. Neuroreport 2000, 11: 2121\u20132125. 10.1097\/00001756-200007140-00013","journal-title":"Neuroreport"},{"key":"306_CR88","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1097\/01.WCB.0000137057.92786.F3","volume":"24","author":"C Ayata","year":"2004","unstructured":"Ayata C, Shin HK, Salomone S, Ozdemir-Gursoy Y, Boas DA, Dunn AK, Moskowitz MA: Pronounced hypoperfusion during spreading depression in mouse cortex. J Cereb Blood Flow Metab 2004, 24: 1172\u20131182.","journal-title":"J Cereb Blood Flow Metab"},{"key":"306_CR89","doi-asserted-by":"publisher","first-page":"4143","DOI":"10.1152\/jn.00028.2007","volume":"97","author":"KC Brennan","year":"2007","unstructured":"Brennan KC, Beltr\u00e1n-Parrazal L, L\u00f3pez-Vald\u00e9s HE, Theriot J, Toga AW, Charles AC: Distinct vascular conduction with cortical spreading depression. J Neurophysiol 2007, 97: 4143\u20134151. 10.1152\/jn.00028.2007","journal-title":"J Neurophysiol"},{"key":"306_CR90","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1093\/brain\/awp338","volume":"133","author":"JC Chang","year":"2010","unstructured":"Chang JC, Shook LL, Biag J, Nguyen EN, Toga AW, Charles AC, Brennan KC: Biphasic direct current shift, haemoglobin desaturation and neurovascular uncoupling in cortical spreading depression. Brain 2010, 133: 996\u20131012. 10.1093\/brain\/awp338","journal-title":"Brain"},{"key":"306_CR91","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1016\/S0028-3908(03)00082-0","volume":"44","author":"M Wang","year":"2003","unstructured":"Wang M, Obrenovich TP, Ureniak J: Effects of the nitric oxide donor, DEA\/NO on cortical spreading depression. Neuropharmacology 2003, 44: 949\u2013957. 10.1016\/S0028-3908(03)00082-0","journal-title":"Neuropharmacology"},{"key":"306_CR92","doi-asserted-by":"crossref","first-page":"H1339","DOI":"10.1152\/ajpheart.00227.2003","volume":"286","author":"J Kleeberg","year":"2004","unstructured":"Kleeberg J, Petzold GC, Major S, Dirnagl U, Dreier JP: ET-1 induces cortical spreading depression via activation of the ETA receptor\/phospholipase C pathway in vivo. Am J Physiol Heart Circ Physiol 2004, 286: H1339-H1346.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"306_CR93","first-page":"204","volume":"232","author":"JP Dreier","year":"2007","unstructured":"Dreier JP, Kleeberg J, Alam M, Major S, Kohl-Bareis M, Petzold GC, Victorov I, Dirnagl U, Obrenovitch TP, Priller J: Endothelin-1-induced spreading depression in rats is associated with a microarea of selective neuronal necrosis. Exp Biol Med (Maywood) 2007, 232: 204\u2013213.","journal-title":"Exp Biol Med (Maywood)"},{"key":"306_CR94","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1016\/S0092-8674(00)81373-2","volume":"87","author":"RA Ophoff","year":"1996","unstructured":"Ophoff RA, Terwindt GM, Vergouwe MN, van Eijk R, Oefner PJ, Hoffman SM, Lamerdin JE, Mohrenweiser HW, Bulman DE, Ferrari M, Haan J, Lindhout D, van Ommen GJ, Hofker MH, Ferrari MD, Frants RR: Familial hemiplegic migraine and episodic ataxia type-2 are caused by mutations in the Ca2+ channel gene CACNL1A4. Cell 1996, 87: 543\u2013552. 10.1016\/S0092-8674(00)81373-2","journal-title":"Cell"},{"key":"306_CR95","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1016\/S0896-6273(04)00085-6","volume":"41","author":"AM van den Maagdenberg","year":"2004","unstructured":"van den Maagdenberg AM, Pietrobon D, Pizzorusso T, Kaja S, Broos LA, Cesetti T, van de Ven RC, Tottene A, van der Kaa J, Plomp JJ, Frants RR, Ferrari MD: A Cacna1a knockin migraine mouse model with increased susceptibility to cortical spreading depression. Neuron 2004, 41: 701\u2013710. 10.1016\/S0896-6273(04)00085-6","journal-title":"Neuron"},{"key":"306_CR96","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.conb.2005.05.010","volume":"15","author":"D Pietrobon","year":"2005","unstructured":"Pietrobon D: Function and dysfunction of synaptic calcium channels: insights from mouse models. Curr Opin Neurobiol 2005, 15: 257\u2013265. 10.1016\/j.conb.2005.05.010","journal-title":"Curr Opin Neurobiol"},{"key":"306_CR97","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1111\/j.1468-2982.2009.01940.x","volume":"29","author":"AH Stam","year":"2009","unstructured":"Stam AH, Haan J, van den Maagdenberg AM, Ferrari MD, Terwindt GM: Migraine and genetic and acquired vasculopathies. Cephalalgia 2009, 29: 1006\u20131017. 10.1111\/j.1468-2982.2009.01940.x","journal-title":"Cephalalgia"},{"key":"306_CR98","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.jphysparis.2011.10.004","volume":"106","author":"OD Uchitel","year":"2012","unstructured":"Uchitel OD, Inchauspe CG, Urbano FJ, Di Guilmi MN: CaV2.1 voltage activated calcium channels and synaptic transmission in familial hemiplegic migraine pathogenesis. J Physiol Paris 2012, 106: 12\u201322. 10.1016\/j.jphysparis.2011.10.004","journal-title":"J Physiol Paris"},{"key":"306_CR99","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1152\/jn.00034.2010","volume":"104","author":"CG Inchauspe","year":"2010","unstructured":"Inchauspe CG, Urbano FJ, Di Guilmi MN, Forsythe ID, Ferrari MD, van den Maagdenberg AM, Uchitel OD: Gain of function in FHM-1 Cav 2.1 knock-in mice is related to the shape of the action potential. J Neurophysiol 2010, 104: 291\u2013299. 10.1152\/jn.00034.2010","journal-title":"J Neurophysiol"},{"key":"306_CR100","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1007\/s00424-010-0802-8","volume":"460","author":"D Pietrobon","year":"2010","unstructured":"Pietrobon D: Cav2.1 channelopathies. Pflugers Arch 2010, 460: 375\u2013393. 10.1007\/s00424-010-0802-8","journal-title":"Pflugers Arch"},{"key":"306_CR101","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.1113\/jphysiol.2010.188003","volume":"588","author":"D Pietrobon","year":"2010","unstructured":"Pietrobon D: Insights into migraine mechanisms and CaV2.1 calcium channel function from mouse models of familial hemiplegic migraine. J Physiol 2010, 588: 1871\u20131878. 10.1113\/jphysiol.2010.188003","journal-title":"J Physiol"},{"key":"306_CR102","doi-asserted-by":"publisher","first-page":"13284","DOI":"10.1073\/pnas.192242399","volume":"99","author":"A Tottene","year":"2002","unstructured":"Tottene A, Fellin T, Pagnutti S, Luvisetto S, Striessnig J, Fletcher C, Pietrobon D: Familial hemiplegic migraine mutations increase Ca2+ influx through single human Cav2.1 channels and decrease maximal Cav2.1 current density in neurons. Proc Natl Acad Sci USA 2002, 99: 13284\u201313289. 10.1073\/pnas.192242399","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5","key":"306_CR103","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1016\/j.neuron.2009.01.027","volume":"61","author":"A Tottene","year":"2009","unstructured":"Tottene A, Conti R, Fabbro A, Vecchia D, Shapovalova M, Santello M, van den Maagdenberg AM, Ferrari MD, Pietrobon D: Enhanced excitatory transmission at cortical synapses as the basis for facilitated spreading depression in Ca(v)2.1 knockin migraine mice. Neuron 2009,61(5):762\u2013773. 10.1016\/j.neuron.2009.01.027","journal-title":"Neuron"},{"key":"306_CR104","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1002\/ana.21815","volume":"67","author":"AM van den Maagdenberg","year":"2010","unstructured":"van den Maagdenberg AM, Pizzorusso T, Kaja S, Terpolilli N, Shapovalova M, Hoebeek FE, Barrett CF, Gherardini L, van de Ven RC, Todorov B, Broos LA, Tottene A, Gao Z, Fodor M, De Zeeuw CI, Frants RR, Plesnila N, Plomp JJ, Pietrobon D, Ferrari MD: High cortical spreading depression susceptibility and migraine-associated symptoms in Cav2.1 S218L mice. Ann Neurol 2010, 67: 85\u201398. 10.1002\/ana.21815","journal-title":"Ann Neurol"},{"key":"306_CR105","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0306-4522(99)00446-7","volume":"95","author":"C Ayata","year":"2000","unstructured":"Ayata C, Shimizu-Sasamata M, Lo EH, Noebels JL, Moskowitz MA: Impaired neurotransmitter release and elevated threshold for cortical spreading depression in mice with mutations in the \u03b11A subunit of P\/Q type calcium channels. Neuroscience 2000, 95: 639\u2013645.","journal-title":"Neuroscience"},{"issue":"6","key":"306_CR106","doi-asserted-by":"publisher","first-page":"e1002129","DOI":"10.1371\/journal.pgen.1002129","volume":"7","author":"L Leo","year":"2011","unstructured":"Leo L, Gherardini L, Barone V, De Fusco M, Pietrobon D, Pizzorusso T, Casari G: Increased susceptibility to cortical spreading depression in the mouse model of familial hemiplegic migraine type 2. PLoS Genet 2011,7(6):e1002129. 10.1371\/journal.pgen.1002129","journal-title":"PLoS Genet"},{"key":"306_CR107","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1002\/ana.22281","volume":"69","author":"K Eikermann-Haerter","year":"2011","unstructured":"Eikermann-Haerter K, Yuzawa I, Dilekoz E, Joutel A, Moskowitz MA, Ayata C: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy syndrome mutations increase susceptibility to spreading depression. Ann Neurol 2011, 69: 413\u2013418. 10.1002\/ana.22281","journal-title":"Ann Neurol"},{"key":"306_CR108","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1046\/j.1468-2982.1990.1003147.x","volume":"10","author":"S Nagel-Leiby","year":"1990","unstructured":"Nagel-Leiby S, Welch KM, Grunfeld S, D\u2019Andrea G: Ovarian steroid levels in migraine with and without aura. Cephalalgia 1990, 10: 147\u2013152. 10.1046\/j.1468-2982.1990.1003147.x","journal-title":"Cephalalgia"},{"key":"306_CR109","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/S1474-4422(04)00768-9","volume":"3","author":"EA MacGregor","year":"2004","unstructured":"MacGregor EA: Oestrogen and attacks of migraine with and without aura. Lancet Neurol 2004, 3: 354\u2013361. 10.1016\/S1474-4422(04)00768-9","journal-title":"Lancet Neurol"},{"key":"306_CR110","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1111\/j.1600-0404.2005.00350.x","volume":"111","author":"JM Ertresvag","year":"2005","unstructured":"Ertresvag JM, Zwart JA, Helde G, Johnsen HJ, Bovim G: Headache and transient focal neurological symptoms during pregnancy, a prospective cohort. Acta Neurol Scand 2005, 111: 233\u2013237. 10.1111\/j.1600-0404.2005.00350.x","journal-title":"Acta Neurol Scand"},{"key":"306_CR111","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1111\/j.1526-4610.1993.hed3307385.x","volume":"33","author":"F Granella","year":"1993","unstructured":"Granella F, Sances G, Zanferrari C, Costa A, Martignoni E, Manzoni GC: Migraine without aura and reproductive life events: a clinical epidemiological study in 1300 women. Headache 1993, 33: 385\u2013389. 10.1111\/j.1526-4610.1993.hed3307385.x","journal-title":"Headache"},{"key":"306_CR112","first-page":"721","volume":"310","author":"GJ Calton","year":"1984","unstructured":"Calton GJ, Burnett JW: Danazol and migraine. N Engl J Med 1984, 310: 721\u2013722.","journal-title":"N Engl J Med"},{"key":"306_CR113","first-page":"102","volume":"74","author":"B Jonsson","year":"1951","unstructured":"Jonsson B, Von Reis G, Sahlgren E: Testosterone therapy of headache. Acta Psychiatr Neurol Scand 1951, 74: 102\u2013105.","journal-title":"Acta Psychiatr Neurol Scand"},{"key":"306_CR114","first-page":"577","volume":"54","author":"RC Moehlig","year":"1955","unstructured":"Moehlig RC: Methyl testosterone for migraine of women; report of sixty cases. J Mich State Med Soc 1955, 54: 577\u2013579.","journal-title":"J Mich State Med Soc"},{"key":"306_CR115","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1212\/WNL.35.4.618","volume":"35","author":"FM Vincent","year":"1985","unstructured":"Vincent FM: Migraine responsive to danazol. Neurology 1985, 35: 618.","journal-title":"Neurology"},{"issue":"6","key":"306_CR116","first-page":"419","volume":"36","author":"EM Lichten","year":"1991","unstructured":"Lichten EM, Bennett RS, Whitty AJ, Daoud Y: Efficacy of danazol in the control of hormonal migraine. J Reprod Med 1991,36(6):419\u2013424.","journal-title":"J Reprod Med"},{"key":"306_CR117","first-page":"977","volume":"24","author":"O Arango","year":"1996","unstructured":"Arango O, Bielsa O, Pascual-Calvet J, Herrero M, Gelabert-Mas A: Disappearance of migraine crises in two patients with male infertility treated with human chorionic gonadotropin\/human menopausal gonadotrophin. Rev Neurol 1996, 24: 977\u2013979.","journal-title":"Rev Neurol"},{"key":"306_CR118","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1212\/01.WNL.0000130338.62037.CC","volume":"63","author":"T Pringsheim","year":"2004","unstructured":"Pringsheim T, Gooren L: Migraine prevalence in male to female transsexuals on hormone therapy. Neurology 2004, 63: 593\u2013594.","journal-title":"Neurology"},{"key":"306_CR119","first-page":"99","volume":"119","author":"K Eikermann-Haerter","year":"2009","unstructured":"Eikermann-Haerter K, Dilek\u00f6z E, Kudo C, Savitz SI, Waeber C, Baum MJ, Ferrari MD, van den Maagdenberg AM, Moskowitz MA, Ayata C: Genetic and hormonal factors modulate spreading depression and transient hemiparesis in mouse models of familial hemiplegic migraine type 1. J Clin Invest 2009, 119: 99\u2013109.","journal-title":"J Clin Invest"},{"key":"306_CR120","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1002\/ana.21779","volume":"66","author":"K Eikermann-Haerter","year":"2009","unstructured":"Eikermann-Haerter K, Baum MJ, Ferrari MD, van den Maagdenberg AM, Moskowitz MA, Ayata C: Androgenic suppression of spreading depression in familial hemiplegic migraine type 1 mutant mice. Ann Neurol 2009, 66: 564\u2013568. 10.1002\/ana.21779","journal-title":"Ann Neurol"},{"key":"306_CR121","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.4065\/80.10.1326","volume":"80","author":"EE Benarroch","year":"2005","unstructured":"Benarroch EE: Neuron-astrocyte interactions: partnership for normal function and disease in the central nervous system. Mayo Clin Proc 2005, 80: 1326\u20131338. 10.4065\/80.10.1326","journal-title":"Mayo Clin Proc"},{"key":"306_CR122","doi-asserted-by":"publisher","first-page":"2446","DOI":"10.1111\/j.0953-816X.2004.03289.x","volume":"19","author":"XY Lian","year":"2004","unstructured":"Lian XY, Stringer JL: Energy failure in astrocytes increases the vulnerability of neurons to spreading depression. Eur J Neurosci 2004, 19: 2446\u20132454. 10.1111\/j.0953-816X.2004.03289.x","journal-title":"Eur J Neurosci"},{"key":"306_CR123","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1124\/jpet.106.117101","volume":"321","author":"XY Lian","year":"2007","unstructured":"Lian XY, Stringer JL: Astrocytes contribute to regulation of extracellular calcium and potassium in the rat cerebral cortex during spreading depression. J Pharmacol Exp Ther 2007, 321: 564\u2013572. 10.1124\/jpet.106.117101","journal-title":"J Pharmacol Exp Ther"},{"key":"306_CR124","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/0166-2236(96)10046-1","volume":"19","author":"C Giaume","year":"1996","unstructured":"Giaume C, McCarthy KD: Control of gap-junctional communication in astrocytic networks. Trends Neurosci 1996, 19: 319\u2013325. 10.1016\/0166-2236(96)10046-1","journal-title":"Trends Neurosci"},{"key":"306_CR125","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1016\/j.tins.2003.09.008","volume":"26","author":"MVL Bennett","year":"2003","unstructured":"Bennett MVL, Contreras JE, Bukauskas FF, S\u00e1ez JC: New roles for astrocytes: gap junction hemichannels have something to communicate. Trends Neurosci 2003, 26: 610\u2013617. 10.1016\/j.tins.2003.09.008","journal-title":"Trends Neurosci"},{"key":"306_CR126","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.brainresrev.2004.05.005","volume":"47","author":"JI Nagy","year":"2004","unstructured":"Nagy JI, Dudek FE, Rash JE: Update on connexins and gap junctions in neurons and glia in the mammalian nervous system. Brain Res Rev 2004, 47: 191\u2013215. 10.1016\/j.brainresrev.2004.05.005","journal-title":"Brain Res Rev"},{"key":"306_CR127","doi-asserted-by":"crossref","first-page":"3588","DOI":"10.1523\/JNEUROSCI.23-09-03588.2003","volume":"23","author":"Z-C Ye","year":"2003","unstructured":"Ye Z-C, Wyeth MS, Baltan-Tekkok S, Ransom BR: Functional hemichannels in astrocytes: a novel mechanism of glutamate release. J Neurosci 2003, 23: 3588\u20133596.","journal-title":"J Neurosci"},{"issue":"30","key":"306_CR128","doi-asserted-by":"crossref","first-page":"9888","DOI":"10.1523\/JNEUROSCI.23-30-09888.2003","volume":"23","author":"O Peters","year":"2003","unstructured":"Peters O, Schipke CG, Hashimoto Y, Kettenmann H: Different mechanisms promote astrocyte Ca 2+ waves and spreading depression in the mouse neocortex. J Neurosci 2003,23(30):9888\u20139896.","journal-title":"J Neurosci"},{"key":"306_CR129","doi-asserted-by":"publisher","first-page":"10482","DOI":"10.1074\/jbc.M109902200","volume":"277","author":"CE Stout","year":"2002","unstructured":"Stout CE, Costantin JL, Naus CCG, Charles AC: Intercellular calcium signaling in astrocytes via ATP release through connexin hemichannels. J Biol Chem 2002, 277: 10482\u201310488. 10.1074\/jbc.M109902200","journal-title":"J Biol Chem"},{"key":"306_CR130","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1002\/1531-8249(200001)47:1<18::AID-ANA6>3.0.CO;2-N","volume":"47","author":"B Grafstein","year":"2000","unstructured":"Grafstein B, Liu S, Cotrina ML, Goldman SA, Nedergaard M: Meningeal cells can communicate with astrocytes by calcium signaling. Ann Neurol 2000, 47: 18\u201325. 10.1002\/1531-8249(200001)47:1<18::AID-ANA6>3.0.CO;2-N","journal-title":"Ann Neurol"},{"key":"306_CR131","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1172\/JCI200421227","volume":"113","author":"Y Gursoy-Ozdemir","year":"2004","unstructured":"Gursoy-Ozdemir Y, Qiu J, Matsuoka N, Bolay H, Bermpohl D, Jin H, Wang X, Rosenberg GA, Lo EH, Moskowitz MA: Cortical spreading depression activates and upregulates MMP-9. J Clin Invest 2004, 113: 1447\u20131455.","journal-title":"J Clin Invest"},{"key":"306_CR132","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.cca.2009.07.008","volume":"408","author":"A Martins-Oliveira","year":"2009","unstructured":"Martins-Oliveira A, Speciali JG, Dach F, Marcaccini AM, Gon\u00e7alves FM, Gerlach RF, Tanus-Santos JE: Different circulating metalloproteinases profiles in women with migraine with and without aura. Clin Chim Acta 2009, 408: 60\u201364. 10.1016\/j.cca.2009.07.008","journal-title":"Clin Chim Acta"},{"key":"306_CR133","first-page":"2559","volume":"123","author":"HM Gao","year":"2010","unstructured":"Gao HM, Li L, Zhang KL, Chen XH, Tian SQ, Zhang ZL: Impact of migraine attacks on the blood\u2013brain barrier. Chin Med J (Engl) 2010, 123: 2559\u20132561.","journal-title":"Chin Med J (Engl)"},{"key":"306_CR134","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.jneuroim.2012.07.016","volume":"252","author":"A Martins-Oliveira","year":"2012","unstructured":"Martins-Oliveira A, Gon\u00e7alves FM, Speciali JG, Fontana V, Izidoro-Toledo TC, Belo VA, Dach F, Tanus-Santos JE: Specific matrix metalloproteinase 9 (MMP-9) haplotype affect the circulating MMP-9 levels in women with migraine. J Neuroimmunol 2012, 252: 89\u201394. 10.1016\/j.jneuroim.2012.07.016","journal-title":"J Neuroimmunol"},{"key":"306_CR135","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.gene.2012.09.109","volume":"512","author":"FM Gon\u00e7alves","year":"2013","unstructured":"Gon\u00e7alves FM, Martins-Oliveira A, Lacchini R, Belo VA, Speciali JG, Dach F, Tanus-Santos JE: Matrix metalloproteinase (MMP)-2 gene polymorphisms affect circulating MMP-2 levels in patients with migraine with aura. Gene 2013, 512: 35\u201340. 10.1016\/j.gene.2012.09.109","journal-title":"Gene"},{"key":"306_CR136","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.1586\/ern.09.103","volume":"9","author":"VK Gupta","year":"2009","unstructured":"Gupta VK: CSD, BBB and MMP-9 elevations: animal experiments versus clinical phenomena in migraine. Expert Rev Neurother 2009, 9: 1595\u20131614. 10.1586\/ern.09.103","journal-title":"Expert Rev Neurother"},{"key":"306_CR137","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1007\/s11916-012-0255-1","volume":"16","author":"D Levy","year":"2012","unstructured":"Levy D: Endogenous mechanisms underlying the activation and sensitization of meningeal nociceptors: the role of immuno-vascular interactions and cortical spreading depression. Curr Pain Headache Rep 2012, 16: 270\u2013277. 10.1007\/s11916-012-0255-1","journal-title":"Curr Pain Headache Rep"},{"issue":"14","key":"306_CR138","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1177\/0333102411422383","volume":"31","author":"GA Lambert","year":"2011","unstructured":"Lambert GA, Truong L, Zagami AS: Effect of cortical spreading depression on basal and evoked traffic in the trigeminovascular sensory system. Cephalalgia 2011,31(14):1439\u20131451. 10.1177\/0333102411422383","journal-title":"Cephalalgia"},{"key":"306_CR139","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1016\/j.tins.2003.09.017","volume":"26","author":"R-R Ji","year":"2003","unstructured":"Ji R-R, Kohno T, Moore KA, Woolf CJ: Central sensitization and LTP: do pain and memory share similar mechanisms? Trends Neurosci 2003, 26: 696\u2013705. 10.1016\/j.tins.2003.09.017","journal-title":"Trends Neurosci"},{"key":"306_CR140","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1177\/0333102411430267","volume":"32","author":"PJ Goadsby","year":"2012","unstructured":"Goadsby PJ, Akerman S: The trigeminovascular system does not require a peripheral sensory input to be activated\u2013migraine is a central disorder. Focus on 'Effect of cortical spreading depression on basal and evoked traffic in the trigeminovascular sensory system'. Cephalalgia 2012, 32: 3\u20135. 10.1177\/0333102411430267","journal-title":"Cephalalgia"},{"key":"306_CR141","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1038\/384560a0","volume":"384","author":"AM Strassman","year":"1996","unstructured":"Strassman AM, Raimond SA, Burstein R: Sensitization of meningeal sensory neurons and the origin of headache. Nature 1996, 384: 560\u2013564. 10.1038\/384560a0","journal-title":"Nature"},{"key":"306_CR142","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1126\/science.1231897","volume":"339","author":"H Karatas","year":"2013","unstructured":"Karatas H, Erdener SE, Gursoy-Ozdemir Y, Lule S, Eren-Ko\u00e7ak E, Sen ZD, Dalkara T: Spreading depression triggers headache by activating neuronal Panx1 channels. Science 2013, 339: 1092\u20131095. 10.1126\/science.1231897","journal-title":"Science"},{"key":"306_CR143","doi-asserted-by":"publisher","first-page":"18143","DOI":"10.1074\/jbc.M109.004804","volume":"284","author":"WR Silverman","year":"2009","unstructured":"Silverman WR, de Rivero Vaccari JP, Locovei S, Qiu F, Carlsson SK, Scemes E, Keane RW, Dahl G: The pannexin 1 channel activates the inflammasome in neurons and astrocytes. J Biol Chem 2009, 284: 18143\u201318151. 10.1074\/jbc.M109.004804","journal-title":"J Biol Chem"},{"key":"306_CR144","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1111\/j.1365-2796.2003.01296.x","volume":"255","author":"S M\u00fcller","year":"2004","unstructured":"M\u00fcller S, Ronfani L, Bianchi ME: Regulated expression and subcellular localization of HMGB1, a chromatin protein with a cytokine function. J Intern Med 2004, 255: 332\u2013343. 10.1111\/j.1365-2796.2003.01296.x","journal-title":"J Intern Med"},{"key":"306_CR145","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1111\/j.1471-4159.2007.04788.x","volume":"103","author":"G Faraco","year":"2007","unstructured":"Faraco G, Fossati S, Bianchi ME, Patrone M, Pedrazzi M, Sparatore B, Moroni F, Chiarugi A: High mobility group box 1 protein is released by neural cells upon different stresses and worsens ischemic neurodegeneration in vitro and in vivo. J Neurochem 2007, 103: 590\u2013603. 10.1111\/j.1471-4159.2007.04788.x","journal-title":"J Neurochem"},{"key":"306_CR146","doi-asserted-by":"crossref","first-page":"8525","DOI":"10.4049\/jimmunol.179.12.8525","volume":"179","author":"S Pontremoli","year":"2007","unstructured":"Pontremoli S, Melloni E: Selective proinflammatory activation of astrocytes by high-mobility group box 1 protein signaling. J Immunol 2007, 179: 8525\u20138532.","journal-title":"J Immunol"},{"key":"306_CR147","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/S0006-8993(00)02400-8","volume":"870","author":"SJ Read","year":"2000","unstructured":"Read SJ, Parsons AA: Sumatriptan modifies cortical free radical release during cortical spreading depression. A novel antimigraine action for sumatriptan? Brain Res 2000, 870: 44\u201353. 10.1016\/S0006-8993(00)02400-8","journal-title":"Brain Res"},{"key":"306_CR148","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/S0006-8993(00)03191-7","volume":"891","author":"SJ Read","year":"2001","unstructured":"Read SJ, Hirst WD, Upton N, Parsons AA: Cortical spreading depression produces increased cGMP levels in cortex and brain stem that is inhibited by tonabersat (SB-220453) but not sumatriptan. Brain Res 2001, 891: 69\u201377. 10.1016\/S0006-8993(00)03191-7","journal-title":"Brain Res"},{"key":"306_CR149","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1111\/j.1468-2982.2009.01982.x","volume":"29","author":"C Ayata","year":"2009","unstructured":"Ayata C: Spreading depression: from serendipity to targeted therapy in migraine prophylaxis. Cephalalgia 2009, 29: 1095\u20131114. 10.1111\/j.1468-2982.2009.01982.x","journal-title":"Cephalalgia"},{"key":"306_CR150","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1159\/000117004","volume":"34","author":"H Kaube","year":"1994","unstructured":"Kaube H, Goadsby PJ: Anti-migraine compounds fail to modulate the propagation of cortical spreading depression in the cat. Eur Neurol 1994, 34: 30\u201335. 10.1159\/000117004","journal-title":"Eur Neurol"},{"key":"306_CR151","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1002\/ana.20778","volume":"59","author":"C Ayata","year":"2006","unstructured":"Ayata C, Jin H, Kudo C, Dalkara T, Moskowitz MA: Suppression of cortical spreading depression in migraine prophylaxis. Ann Neurol 2006, 59: 652\u2013661. 10.1002\/ana.20778","journal-title":"Ann Neurol"},{"key":"306_CR152","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1177\/0333102412444015","volume":"32","author":"M Unekawa","year":"2012","unstructured":"Unekawa M, Tomita Y, Toriumi H, Suzuki N: Suppressive effect of chronic peroral topiramate on potassium-induced cortical spreading depression in rats. Cephalalgia 2012, 32: 518\u2013527. 10.1177\/0333102412444015","journal-title":"Cephalalgia"},{"key":"306_CR153","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1097\/01.wnr.0000175250.33159.a9","volume":"16","author":"S Akerman","year":"2005","unstructured":"Akerman S, Goadsby PJ: Topiramate inhibits cortical spreading depression in rat and cat: impact in migraine aura. Neuroreport 2005, 16: 1383\u20131387. 10.1097\/01.wnr.0000175250.33159.a9","journal-title":"Neuroreport"},{"key":"306_CR154","doi-asserted-by":"publisher","first-page":"1588","DOI":"10.1038\/jcbfm.2010.92","volume":"30","author":"U Hoffmann","year":"2010","unstructured":"Hoffmann U, Dilek\u00f6z E, Kudo C, Ayata C: Gabapentin suppresses cortical spreading depression susceptibility. J Cereb Blood Flow Metab 2010, 30: 1588\u20131592. 10.1038\/jcbfm.2010.92","journal-title":"J Cereb Blood Flow Metab"},{"key":"306_CR155","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1111\/j.1468-2982.1999.1901064.x","volume":"19","author":"G D'Andrea","year":"1999","unstructured":"D'Andrea G, Granella F, Cadaldini M, Manzoni GC: Effectiveness of lamotrigine in the prophylaxis of migraine with aura: an open pilot study. Cephalalgia 1999, 19: 64\u201366. 10.1111\/j.1468-2982.1999.1901064.x","journal-title":"Cephalalgia"},{"key":"306_CR156","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1111\/j.1468-2982.1999.1901058.x","volume":"19","author":"C Lampl","year":"1999","unstructured":"Lampl C, Buzath A, Klinger D, Neumann K: Lamotrigine in the prophylactic treatment of migraine aura\u2013a pilot study. Cephalalgia 1999, 19: 58\u201363. 10.1111\/j.1468-2982.1999.1901058.x","journal-title":"Cephalalgia"},{"key":"306_CR157","doi-asserted-by":"publisher","first-page":"1730","DOI":"10.1136\/jnnp.2005.063750","volume":"76","author":"C Lampl","year":"2005","unstructured":"Lampl C, Katsarava Z, Diener HC, Limmroth V: Lamotrigine reduces migraine aura and migraine attacks in patients with migraine with aura. J Neurol Neurosurg Psychiatry 2005, 76: 1730\u20131732. 10.1136\/jnnp.2005.063750","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"306_CR158","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1046\/j.1468-2982.1997.1702109.x","volume":"17","author":"TJ Steiner","year":"1997","unstructured":"Steiner TJ, Findley LJ, Yuen AW: Lamotrigine versus placebo in the prophylaxis of migraine with and without aura. Cephalalgia 1997, 17: 109\u2013112. 10.1046\/j.1468-2982.1997.1702109.x","journal-title":"Cephalalgia"},{"key":"306_CR159","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1111\/j.1526-4610.2006.00599.x","volume":"47","author":"P Gupta","year":"2007","unstructured":"Gupta P, Singh S, Goyal V, Shukla G, Behari M: Low-dose topiramate versus lamotrigine in migraine prophylaxis (the Lotolamp study). Headache 2007, 47: 402\u2013412.","journal-title":"Headache"},{"key":"306_CR160","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/j.nbd.2010.10.014","volume":"41","author":"VB Bogdanov","year":"2011","unstructured":"Bogdanov VB, Multon S, Chauvel V, Bogdanova OV, Prodanov D, Makarchuk MY, Schoenen J: Migraine preventive drugs differentially affect cortical spreading depression in rat. Neurobiol Dis 2011, 41: 430\u2013435. 10.1016\/j.nbd.2010.10.014","journal-title":"Neurobiol Dis"},{"key":"306_CR161","first-page":"158","volume-title":"The Prelude to The Migraine Attack","author":"R Marrannes","year":"1986","unstructured":"Marrannes R, Wauquier A, Reid K, De Prins E: The Prelude to The Migraine Attack. UK: Effects of drugs on cortical spreading depression. Bailli\u00e8re Tindal Oxford; 1986:158\u2013173."},{"key":"306_CR162","first-page":"161","volume-title":"The Pharmacological Basis of Migraine Therapy","author":"A Hansen","year":"1984","unstructured":"Hansen A, Lauritzen M, Tfelt-Hansen P: Spreading cortical depression and antimigraine drugs. In The Pharmacological Basis of Migraine Therapy. Edited by: Amery WK, Nueten JM, Waquier A. London, UK: Putman; 1984:161\u2013170."},{"key":"306_CR163","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1002\/ddr.430100210","volume":"10","author":"KH Reid","year":"1987","unstructured":"Reid KH, Marrannes R, Wauquier A: Effects of flunarizine on rat cerebral cortex. Drug Dev Res 1987, 10: 107\u2013116. 10.1002\/ddr.430100210","journal-title":"Drug Dev Res"},{"issue":"2","key":"306_CR164","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1177\/03331024850050S222","volume":"5","author":"A Wauquier","year":"1985","unstructured":"Wauquier A, Ashton D, Marrannes R: The effects of flunarizine in experimental models related to the pathogenesis of migraine. Cephalalgia 1985,5(2):119\u2013123.","journal-title":"Cephalalgia"},{"key":"306_CR165","first-page":"431","volume-title":"Migraine: Basic Mechanisms and Treatment","author":"R Marrannes","year":"1993","unstructured":"Marrannes R, De Prins E, Fransen J, Clincke G: Neuropharmacology of spreading depression. In Migraine: Basic Mechanisms and Treatment. Edited by: Lehmenkuhler A, Grotemeyer KH, Tegtmeier F. Urban & Schwarzenberg: MD, USA; 1993:431\u2013443."},{"key":"306_CR166","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1111\/j.1476-5381.1995.tb16624.x","volume":"115","author":"M Shimazawa","year":"1995","unstructured":"Shimazawa M, Hara H, Watano T, Sukamoto T: Effects of Ca 2+ channel blockers on cortical hypoperfusion and expression of c-Fos-like immunoreactivity after cortical spreading depression in rats. Br J Pharmacol 1995, 115: 1359\u20131368. 10.1111\/j.1476-5381.1995.tb16624.x","journal-title":"Br J Pharmacol"},{"key":"306_CR167","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1046\/j.1468-2982.1992.1201021.x","volume":"12","author":"P Sarchielli","year":"1992","unstructured":"Sarchielli P, Coata G, Firenze C, Morucci P, Abbritti G, Gallai V: Serum and salivary magnesium levels in migraine and tension-type headache. Results in a group of adult patients. Cephalalgia 1992, 12: 21\u201327. 10.1046\/j.1468-2982.1992.1201021.x","journal-title":"Cephalalgia"},{"key":"306_CR168","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1111\/j.1526-4610.1994.hed3403160.x","volume":"34","author":"V Gallai","year":"1994","unstructured":"Gallai V, Sarchielli P, Morucci P, Abbritti G: Magnesium content of mononuclear blood cells in migraine patients. Headache 1994, 34: 160\u2013165. 10.1111\/j.1526-4610.1994.hed3403160.x","journal-title":"Headache"},{"key":"306_CR169","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1046\/j.1468-2982.1993.1302094.x","volume":"13","author":"V Gallai","year":"1993","unstructured":"Gallai V, Sarchielli P, Morucci P, Abbritti G: Red blood cell magnesium levels in migraine patients. Cephalalgia 1993, 13: 94\u2013101. 10.1046\/j.1468-2982.1993.1302094.x","journal-title":"Cephalalgia"},{"key":"306_CR170","first-page":"24","volume":"5","author":"A Mauskop","year":"1998","unstructured":"Mauskop A, Altura BM: Role of magnesium in the pathogenesis and treatment of migraines. Clin Neurosci 1998, 5: 24\u201327.","journal-title":"Clin Neurosci"},{"key":"306_CR171","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1111\/j.1526-4610.1989.hed2909590.x","volume":"29","author":"NM Ramadan","year":"1989","unstructured":"Ramadan NM, Halvorson H, Vande-Linde A, Levine SR, Helpern JA, Welch KM: Low brain magnesium in migraine. Headache 1989, 29: 590\u2013593. 10.1111\/j.1526-4610.1989.hed2909590.x","journal-title":"Headache"},{"key":"306_CR172","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1046\/j.1468-2982.2002.00364.x","volume":"22","author":"ME Bigal","year":"2002","unstructured":"Bigal ME, Bordini CA, Tepper SJ, Speciali JG: Intravenous magnesium sulphate in the acute treatment of migraine without aura and migraine with aura. A randomized, double-blind, placebo-controlled study. Cephalalgia 2002, 22: 345\u2013353. 10.1046\/j.1468-2982.2002.00364.x","journal-title":"Cephalalgia"},{"key":"306_CR173","doi-asserted-by":"publisher","first-page":"2179","DOI":"10.1097\/00001756-199807130-00006","volume":"9","author":"WS van der Hel","year":"1998","unstructured":"van der Hel WS, van den Bergh WM, Nicolay K, Tulleken KA, Dijkhuizen RM: Suppression of cortical spreading depressions after magnesium treatment in the rat. Neuroreport 1998, 9: 2179\u20132182. 10.1097\/00001756-199807130-00006","journal-title":"Neuroreport"},{"key":"306_CR174","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1212\/01.wnl.0000297551.27191.70","volume":"70","author":"S Silberstein","year":"2008","unstructured":"Silberstein S, Saper J, Berenson F, Somogyi M, McCague K, D\u2019Souza J: Oxcarbazepine in migraine headache: a double-blind, randomized, placebo-controlled study. Neurology 2008, 70: 548\u2013555. 10.1212\/01.wnl.0000297551.27191.70","journal-title":"Neurology"},{"issue":"Suppl 2","key":"306_CR175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1468-2982.2009.01976.x","volume":"29","author":"PL Durham","year":"2009","unstructured":"Durham PL, Garrett FG: Neurological mechanisms of migraine: potential of the gap-junction modulator tonabersat in prevention of migraine. Cephalalgia 2009,29(Suppl 2):1\u20136.","journal-title":"Cephalalgia"},{"issue":"Suppl 2","key":"306_CR176","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1468-2982.2009.01974.x","volume":"29","author":"SD Silberstein","year":"2009","unstructured":"Silberstein SD, Schoenen J, G\u00f6bel H, Diener HC, Elkind AH, Klapper JA, Howard RA: Tonabersat, a gap-junction modulator: efficacy and safety in two randomized, placebo-controlled, dose-ranging studies of acute migraine. Cephalalgia 2009,29(Suppl 2):17\u201327.","journal-title":"Cephalalgia"},{"key":"306_CR177","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1111\/j.1468-2982.2008.01804.x","volume":"29","author":"PJ Goadsby","year":"2009","unstructured":"Goadsby PJ, Ferrari MD, Csanyi A, Olesen J, Mills JG: Tonabersat TON-01\u201305 Study Group. Randomized, double-blind, placebo-controlled, proof-of-concept study of the cortical spreading depression inhibiting agent tonabersat in migraine prophylaxis. Cephalalgia 2009, 29: 742\u2013750. 10.1111\/j.1468-2982.2008.01804.x","journal-title":"Cephalalgia"},{"issue":"Suppl 2","key":"306_CR178","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1468-2982.2009.01975.x","volume":"29","author":"CG Dahl\u00f6f","year":"2009","unstructured":"Dahl\u00f6f CG, Hauge AW, Olesen J: Efficacy and safety of tonabersat, a gap-junction modulator, in the acute treatment of migraine: a double-blind, parallel-group, randomized study. Cephalalgia 2009,29(Suppl 2):7\u201316.","journal-title":"Cephalalgia"},{"key":"306_CR179","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1016\/S1474-4422(09)70135-8","volume":"8","author":"AW Hauge","year":"2009","unstructured":"Hauge AW, Asghar MS, Schytz HW, Christensen K, Olesen J: Effects of tonabersat on migraine with aura: a randomised, double-blind, placebo-controlled crossover study. Lancet Neurol 2009, 8: 718\u2013723. 10.1016\/S1474-4422(09)70135-8","journal-title":"Lancet Neurol"},{"key":"306_CR180","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1006\/exnr.2001.7809","volume":"172","author":"DP Bradley","year":"2001","unstructured":"Bradley DP, Smith MI, Netsiri C, Smith JM, Bockhorst KH, Hall LD, Huang CL, Leslie RA, Parsons AA, James MF: Diffusion-Weighted MRI Used to Detect in Vivo Modulation of Cortical Spreading Depression: Comparison of Sumatriptan and Tonabersat. Exp Neurol 2001, 172: 342\u2013353. 10.1006\/exnr.2001.7809","journal-title":"Exp Neurol"},{"key":"306_CR181","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/j.1526-4610.2008.01262.x","volume":"49","author":"S Damodaram","year":"2009","unstructured":"Damodaram S, Thalakoti S, Freeman SE, Garrett FG, Durham PL: Tonabersat inhibits trigeminal ganglion neuronal-satellite glial cell signaling. Headache 2009, 49: 5\u201320. 10.1111\/j.1526-4610.2008.01262.x","journal-title":"Headache"},{"key":"306_CR182","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1002\/ana.23653","volume":"72","author":"PR Holland","year":"2012","unstructured":"Holland PR, Akerman S, Andreou AP, Karsan N, Wemmie JA, Goadsby PJ: Acid-sensing ion channel 1: a novel therapeutic target for migraine with aura. Ann Neurol 2012, 72: 559\u2013563. 10.1002\/ana.23653","journal-title":"Ann Neurol"},{"key":"306_CR183","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1111\/j.1526-4610.2012.02262.x","volume":"53","author":"PL Durham","year":"2013","unstructured":"Durham PL, Masterson CG: Two mechanisms involved in trigeminal CGRP release: implications for migraine treatment. Headache 2013, 53: 67\u201380. 10.1111\/j.1526-4610.2012.02262.x","journal-title":"Headache"},{"key":"306_CR184","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.pain.2010.09.036","volume":"152","author":"J Yan","year":"2011","unstructured":"Yan J, Edelmayer RM, Wei X, De Felice M, Porreca F, Dussor G: Dural afferents express acid-sensing ion channels: A role for decreased meningeal pH in migraine headache. Pain 2011, 152: 106\u2013113. 10.1016\/j.pain.2010.09.036","journal-title":"Pain"},{"key":"306_CR185","doi-asserted-by":"crossref","first-page":"e36","DOI":"10.1017\/S1462399411002067","volume":"13","author":"AC Raddant","year":"2011","unstructured":"Raddant AC, Russo AF: Calcitonin gene-related peptide in migraine: intersection of peripheral inflammation and central modulation. Expert Rev Mol Med 2011, 13: e36.","journal-title":"Expert Rev Mol Med"},{"key":"306_CR186","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1007\/978-3-540-79090-7_13","volume":"194","author":"VS Seybold","year":"2009","unstructured":"Seybold VS: The role of peptides in central sensitization. Handb Exp Pharmacol 2009, 194: 451\u2013491. 10.1007\/978-3-540-79090-7_13","journal-title":"Handb Exp Pharmacol"},{"key":"306_CR187","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1016\/0006-8993(94)91234-3","volume":"637","author":"M Wahl","year":"1994","unstructured":"Wahl M, Schilling L, Parsons AA, Kaumann A: Involvement of calcitonin gene-related peptide (CGRP) and nitric oxide (NO) in the pial artery dilatation elicited by cortical spreading depression. Brain Res 1994, 637: 2004\u20132010.","journal-title":"Brain Res"},{"key":"306_CR188","first-page":"H1095","volume":"266","author":"DM Colonna","year":"1994","unstructured":"Colonna DM, Meng W, Deal DD, Busija DW: Calcitonin gene-related peptide promotes cerebrovascular dilation during cortical spreading depression in rabbits. Am J Physiol 1994, 266: H1095-H1102.","journal-title":"Am J Physiol"},{"key":"306_CR189","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.jneuroim.2011.05.013","volume":"237","author":"A De Corato","year":"2011","unstructured":"De Corato A, Lisi L, Capuano A, Tringali G, Tramutola A, Navarra P, Dello Russo C: Trigeminal satellite cells express functional calcitonin gene-related peptide receptors, whose activation enhances interleukin-1\u03b2 pro-inflammatory effects. J Neuroimmunol 2011, 237: 39\u201346. 10.1016\/j.jneuroim.2011.05.013","journal-title":"J Neuroimmunol"},{"key":"306_CR190","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1046\/j.1468-2982.1993.1303180.x","volume":"13","author":"P Piper RD","year":"1993","unstructured":"Piper RD P, Edvinsson L, Ekman R, Lambert GA: Cortical spreading depression does not result in the release of calcitonin gene-related peptide into the external jugular vein of the cat: relevance to human migraine. Cephalalgia 1993, 13: 180\u2013183. 10.1046\/j.1468-2982.1993.1303180.x","journal-title":"Cephalalgia"},{"key":"306_CR191","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1177\/0333102410368444","volume":"30","author":"JM Hansen","year":"2010","unstructured":"Hansen JM, Hauge AW, Olesen J, Ashina M: Calcitonin gene-related peptide triggers migraine-like attacks in patients with migraine with aura. Cephalalgia 2010, 30: 1179\u20131186. 10.1177\/0333102410368444","journal-title":"Cephalalgia"},{"key":"306_CR192","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1517\/13543784.2012.681044","volume":"21","author":"A Negro","year":"2012","unstructured":"Negro A, Lionetto L, Simmaco M, Martelletti P: CGRP receptor antagonists: an expanding drug class for acute migraine? Expert Opin Investig Drugs 2012, 21: 807\u2013818. 10.1517\/13543784.2012.681044","journal-title":"Expert Opin Investig Drugs"},{"key":"306_CR193","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1007\/s11940-011-0155-4","volume":"14","author":"J Hoffmann","year":"2012","unstructured":"Hoffmann J, Goadsby PJ: New Agents for Acute Treatment of Migraine: CGRP Receptor Antagonists, iNOS Inhibitors. Curr Treat Options Neurol 2012, 14: 50\u201359. 10.1007\/s11940-011-0155-4","journal-title":"Curr Treat Options Neurol"},{"key":"306_CR194","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1177\/0333102410388435","volume":"31","author":"HC Diener","year":"2011","unstructured":"Diener HC, Barbanti P, Dahl\u00f6f C, Reuter U, Habeck J, Podhorna J: BI 44370 TA, an oral CGRP antagonist for the treatment of acute migraine attacks: results from a phase II study. Cephalalgia 2011, 31: 573\u2013584. 10.1177\/0333102410388435","journal-title":"Cephalalgia"},{"key":"306_CR195","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.expneurol.2012.05.002","volume":"236","author":"V Chauvel","year":"2012","unstructured":"Chauvel V, Vamos E, Pardutz A, Vecsei L, Schoenen J, Multon S: Effect of systemic kynurenine on cortical spreading depression and its modulation by sex hormones in rat. Exp Neurol 2012, 236: 207\u2013214. 10.1016\/j.expneurol.2012.05.002","journal-title":"Exp Neurol"},{"key":"306_CR196","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/s005400050035","volume":"13","author":"K Hirota","year":"1999","unstructured":"Hirota K, Sikand KS, Lambert DG: Interaction of ketamine with mu2 opioid receptors in SH-SY5Y human neuroblastoma cells. J Anesth 1999, 13: 107\u2013109. 10.1007\/s005400050035","journal-title":"J Anesth"},{"key":"306_CR197","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1080\/13556210020077091","volume":"6","author":"M Narita","year":"2001","unstructured":"Narita M, Yoshizawa K, Aoki K, Takagi M, Miyatake M, Suzuki T: A putative sigma1 receptor antagonist NE-100 attenuates the discriminative stimulus effects of ketamine in rats. Addict Biol 2001, 6: 373\u2013376. 10.1080\/13556210020077091","journal-title":"Addict Biol"},{"key":"306_CR198","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/0013-4694(87)90213-6","volume":"66","author":"NA Gorelova","year":"1987","unstructured":"Gorelova NA, Koroleva VI, Amemori T, Pavl\u00edk V, Bur\u0115s J: Ketamine blockade of cortical spreading depression in rats. Electroencephalogr Clin Neurophysiol 1987, 66: 440\u2013447. 10.1016\/0013-4694(87)90213-6","journal-title":"Electroencephalogr Clin Neurophysiol"},{"key":"306_CR199","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/0006-8993(95)00692-J","volume":"693","author":"A Rashidy-Pour","year":"1995","unstructured":"Rashidy-Pour A, Motaghed-Larijani Z, Bures J: Tolerance to ketamine-induced blockade of cortical spreading depression transfers to MK-801 but not to AP5 in rats. Brain Res 1995, 693: 64\u201369. 10.1016\/0006-8993(95)00692-J","journal-title":"Brain Res"},{"key":"306_CR200","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1212\/WNL.55.1.139","volume":"55","author":"H Kaube","year":"2000","unstructured":"Kaube H, Herzog J, K\u00e4ufer T, Dichgans M, Diener HC: Aura in some patients with familial hemiplegic migraine can be stopped by intranasal ketamine. Neurology 2000, 55: 139\u2013141. 10.1212\/WNL.55.1.139","journal-title":"Neurology"},{"key":"306_CR201","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1212\/WNL.0b013e3182824e66","volume":"80","author":"SK Afridi","year":"2013","unstructured":"Afridi SK, Giffin NJ, Kaube H, Goadsby PJ: A randomized controlled trial of intranasal ketamine in migraine with prolonged aura. Neurology 2013, 80: 642\u2013647. 10.1212\/WNL.0b013e3182824e66","journal-title":"Neurology"},{"key":"306_CR202","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.neulet.2012.02.058","volume":"514","author":"A Dhir","year":"2012","unstructured":"Dhir A, Lossin C, Rogawski MA: Propofol hemisuccinate suppresses cortical spreading depression. Neurosci Lett 2012, 514: 67\u201370. 10.1016\/j.neulet.2012.02.058","journal-title":"Neurosci Lett"},{"key":"306_CR203","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.neuropharm.2012.10.018","volume":"67","author":"C Kudo","year":"2013","unstructured":"Kudo C, Toyama M, Boku A, Hanamoto H, Morimoto Y, Sugimura M, Niwa H: Anesthetic effects on susceptibility to cortical spreading depression. Neuropharmacol 2013, 67: 32\u201336.","journal-title":"Neuropharmacol"},{"key":"306_CR204","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.expneurol.2008.03.026","volume":"212","author":"C Kudo","year":"2008","unstructured":"Kudo C, Nozari A, Moskowitz MA, Ayata C: The impact of anesthetics and hyperoxia on cortical spreading depression. Exp Neurol 2008, 212: 201\u2013206. 10.1016\/j.expneurol.2008.03.026","journal-title":"Exp Neurol"},{"key":"306_CR205","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1177\/0333102410375626","volume":"31","author":"O Summ","year":"2011","unstructured":"Summ O, Holland PR, Akerman S, Goadsby PJ: TRPV1 receptor blockade is ineffective in different in vivo models of migraine. Cephalalgia 2011, 31: 172\u2013180. 10.1177\/0333102410375626","journal-title":"Cephalalgia"},{"key":"306_CR206","first-page":"926","volume":"15","author":"H Kazemi","year":"2012","unstructured":"Kazemi H, Rahgozar M, Speckmann EJ, Gorji A: Effect of cannabinoid receptor activation on spreading depression. Iran J Basic Med Sci 2012, 15: 926\u2013936.","journal-title":"Iran J Basic Med Sci"}],"container-title":["The Journal of Headache and Pain"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1129-2377-14-62\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1129-2377-14-62.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1129-2377-14-62.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T07:01:13Z","timestamp":1715756473000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejournalofheadacheandpain.biomedcentral.com\/articles\/10.1186\/1129-2377-14-62"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,23]]},"references-count":206,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["306"],"URL":"https:\/\/doi.org\/10.1186\/1129-2377-14-62","relation":{},"ISSN":["1129-2369","1129-2377"],"issn-type":[{"value":"1129-2369","type":"print"},{"value":"1129-2377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,23]]},"assertion":[{"value":"5 June 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 July 2013","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 July 2013","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"62"}}