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Control sheep were SRLV-seropositive asymptomatic (<jats:italic>n<\/jats:italic>\u2009=\u20093), seronegative (<jats:italic>n<\/jats:italic>\u2009=\u20093) or with chronic listeriosis, pseudotuberculosis or parasitic cysts (<jats:italic>n<\/jats:italic>\u2009=\u20091 in each case). MR expression and proviral load increased with the severity of lesions in most analyzed organs of the SRLV infected sheep and was detected in the affected tissue involved in the corresponding clinical disease (CNS, lung and carpal joint in neurological disease, pneumonia and arthritis animal groups, respectively). The increased MR expression appeared to be SRLV specific and may have a role in lentiviral pathogenesis.<\/jats:p>","DOI":"10.1186\/1297-9716-43-43","type":"journal-article","created":{"date-parts":[[2012,5,16]],"date-time":"2012-05-16T15:44:49Z","timestamp":1337183089000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Mannose receptor may be involved in small ruminant lentivirus pathogenesis"],"prefix":"10.1186","volume":"43","author":[{"given":"Helena","family":"Crespo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Jauregui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Idoia","family":"Glaria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia","family":"Sanjos\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Polledo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan F","family":"Garc\u00eda-Mar\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Llu\u00eds","family":"Luj\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dami\u00e1n","family":"de Andr\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Amorena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rams\u00e9s","family":"Reina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,5,16]]},"reference":[{"key":"188_CR1","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1136\/vr.129.3.51","volume":"129","author":"L Lujan","year":"1991","unstructured":"Lujan L, Garcia Marin JF, Fernandez de Luco D, Vargas A, Badiola JJ: Pathological changes in the lungs and mammary glands of sheep and their relationship with maedi-visna infection. 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