{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T02:02:22Z","timestamp":1794276142775,"version":"4.9.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Vet Res"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Streptococcus equi<\/jats:italic>subsp.<jats:italic>zooepidemicus<\/jats:italic>is the pathogen most commonly isolated from the uterus of mares.<jats:italic>S. zooepidemicus<\/jats:italic>is an opportunistic pathogen and part of the resident flora in the caudal reproductive tract. The aim of this study was to investigate whether a genotypically distinct subpopulation of<jats:italic>S. zooepidemicus<\/jats:italic>is associated with endometritis in the mare, by genotyping and comparing uterine<jats:italic>S. zooepidemicus<\/jats:italic>strains with isolates from the vagina and clitoral fossa. Mares with (<jats:italic>n<\/jats:italic>\u2009=\u200918) or without (<jats:italic>n<\/jats:italic>\u2009=\u200911) clinical symptoms of endometritis were included. Uterine samples were obtained using a guarded endometrial biopsy punch, whereas a swab was used to recover samples from the cranial vagina and the clitoral fossa. If<jats:italic>S. zooepidemicus<\/jats:italic>was present, up to three colonies were selected from each anatomical location (max. 9 isolates per mare). Bacterial isolates were characterized by pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST).<jats:italic>S. zooepidemicus<\/jats:italic>was isolated from the endometrium of 12 mares. A total of 88 isolates were analyzed by PFGE: 31 from the endometrium, 26 from the cranial vagina and 31 isolates from the clitoral fossa. For MLST 21 isolates were chosen. Results demonstrated a higher genetic similarity of the isolates obtained from infectious endometritis compared to isolates obtained from the caudal reproductive tract. In conclusion, we demonstrate for the first time that a genetically distinct group of<jats:italic>S. zooepidemicus<\/jats:italic>is associated with infectious endometritis in the mare.<\/jats:p>","DOI":"10.1186\/1297-9716-44-26","type":"journal-article","created":{"date-parts":[[2013,4,18]],"date-time":"2013-04-18T16:44:28Z","timestamp":1366303468000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Streptococcus equi subsp. zooepidemicus isolates from equine infectious endometritis belong to a distinct genetic group"],"prefix":"10.1186","volume":"44","author":[{"given":"Camilla Dooleweerdt","family":"Rasmussen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Mathilde","family":"Haugaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten Roenn","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper M\u00f8ller","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanne Gervi","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders Miki","family":"Bojesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,4,18]]},"reference":[{"key":"233_CR1","first-page":"181","volume-title":"Hagan and Bruner's microbiology and infectious diseases of domestic animals","author":"JF Timoney","year":"1998","unstructured":"Timoney JF, Gillespie JH, Scott FW, Barlough JE: The genus streptococcus. 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