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The aim of this study was to investigate whether Arm could exert anti-hepatic fibrogenic effects <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic>. A cell line of rat HSCs (HSC-T6) was stimulated with tumor necrosis factor-\u03b1 (TNF-\u03b1) or lipopolysaccharide (LPS) to evaluate the inhibitory effects of Arm. An <jats:italic>in vivo<\/jats:italic> therapeutic study was conducted in bile duct-ligated (BDL) rats. BDL rats were given Arm (3 or 10 mg\/kg) by gavage twice daily for 3 weeks starting from the onset of BDL. Liver sections were taken for fibrosis scoring, immuno-fluorescence staining and quantitative real-time mRNA measurements. <jats:italic>In vitro<\/jats:italic>, Arm (1-10 \u03bcM) concentration-dependently attenuated TNF-\u03b1- and LPS-stimulated \u03b1-SMA protein expression and AP-1 activation by HSC-T6 cells without adverse cytotoxicity. Arm also suppressed TNF-\u03b1-induced collagen collagen deposition, NF\u03baB activation and MAPK (p38, ERK1\/2, and JNK) phosphorylations. <jats:italic>In vivo<\/jats:italic>, Arm treatment significantly reduced plasma AST and ALT levels, hepatic \u03b1-SMA expression and collagen contents, and fibrosis scores of BDL rats as compared with vehicle treatment. Moreover, Arm attenuated the mRNA expression levels of <jats:italic>col 1\u03b12, TGF-\u03b21<\/jats:italic>, <jats:italic>TIMP-1, ICAM-1<\/jats:italic>, <jats:italic>iNOS<\/jats:italic>, and <jats:italic>IL-6<\/jats:italic> genes, but up-regulated <jats:italic>metallothionein<\/jats:italic> genes. Our study results showed that Arm exerted both <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> antifibrotic effects in rats, possibly through anti-NF-\u03baB activation pathways.<\/jats:p>","DOI":"10.1186\/1423-0127-16-78","type":"journal-article","created":{"date-parts":[[2009,9,2]],"date-time":"2009-09-02T06:27:17Z","timestamp":1251872837000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Inhibitory effects of armepavine against hepatic fibrosis in rats"],"prefix":"10.1186","volume":"16","author":[{"given":"Ting-Chun","family":"Weng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Chang","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung-Tsung","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Lian","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Deng","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Tsau","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,9,2]]},"reference":[{"key":"78_CR1","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1053\/j.gastro.2008.03.003","volume":"134","author":"SL Friedman","year":"2008","unstructured":"Friedman SL: Mechanisms of hepatic fibrogenesis. 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