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With a mouse model, the present study showed that myelin-specific antibodies appeared in sera, particularly in those mice with evident symptoms. Meanwhile, specific T cells proliferating in response to stimulation by myelin basic protein (MBP) was also shown in these mice. Taken together, our results suggest that autoimmunity may play an important role in the destruction of components, <jats:italic>e.g<\/jats:italic>., MBP, of axon-surrounding myelin, resulting in demyelination in the mouse brain after infection with the JE virus.<\/jats:p>","DOI":"10.1186\/1423-0127-18-20","type":"journal-article","created":{"date-parts":[[2011,3,2]],"date-time":"2011-03-02T00:03:48Z","timestamp":1299024228000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Autoimmunity-related demyelination in infection by Japanese encephalitis virus"],"prefix":"10.1186","volume":"18","author":[{"given":"Yu-Fen","family":"Tseng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chien-Chih","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuen-Kuei","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching-Kai","family":"Chuang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-June","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,2,28]]},"reference":[{"key":"272_CR1","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1056\/NEJMra030476","volume":"351","author":"T Solomon","year":"2004","unstructured":"Solomon T: Flavivirus encephalitis. 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