{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T03:03:57Z","timestamp":1789787037210,"version":"4.0.1"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Biomed Sci"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>The apolipoprotein E4 (apoE4) genotype is a major risk factor for developing late-onset Alzheimer\u2019s disease (AD). Inheritance of apoE4 is also associated with impairments in olfactory function in early stages of AD. In this project we examined the effects of the three common isoforms of human apoE (apoE2, apoE3, and apoE4) on neuronal differentiation and neurite outgrowth in explant cultures of mouse olfactory epithelium (OE).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The OE cultures derived from apoE-deficient\/knockout (KO) mice have significantly fewer neurons with shorter neurite outgrowth than cultures from wild-type (WT) mice. Treatment of the apoE KO culture with either purified human apoE2 or with human apoE3 significantly increased neurite outgrowth. In contrast, treatment with apoE4 did not have an effect on neurite outgrowth. The differential effects of human apoE isoforms on neurite outgrowth were abolished by blocking the low-density lipoprotein receptor-related protein (LRP) with lactoferrin and receptor-associated protein (RAP).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>ApoE2 and apoE3 stimulate neurite outgrowth in OE cultures by interacting with the lipoprotein receptor, LRP. ApoE4, the isoform associated with AD, failed to promote neurite outgrowth, suggesting a potential mechanism whereby apoE4 may lead to olfactory dysfunction in AD patients.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1423-0127-20-49","type":"journal-article","created":{"date-parts":[[2013,7,12]],"date-time":"2013-07-12T00:14:14Z","timestamp":1373588054000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Isoform-specific effects of ApoE on neurite outgrowth in Olfactory Epithelium culture"],"prefix":"10.1186","volume":"20","author":[{"given":"Aseem","family":"Hussain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minh","family":"Luong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apryl","family":"Pooley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britto P","family":"Nathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,7,12]]},"reference":[{"key":"497_CR1","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1126\/science.3283935","volume":"240","author":"RW Mahley","year":"1988","unstructured":"Mahley RW: Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science. 1988, 240: 622-630. 10.1126\/science.3283935.","journal-title":"Science"},{"key":"497_CR2","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1126\/science.3513311","volume":"232","author":"MS Brown","year":"1986","unstructured":"Brown MS, Goldstein JL: A receptor-mediated pathway for cholesterol homeostasis. Science. 1986, 232: 34-47. 10.1126\/science.3513311.","journal-title":"Science"},{"key":"497_CR3","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/S0065-3233(08)60642-7","volume":"45","author":"KH Weisgraber","year":"1994","unstructured":"Weisgraber KH: Apolipoprotein E: structure-function relationships. Adv Protein Chem. 1994, 45: 249-302.","journal-title":"Adv Protein Chem"},{"key":"497_CR4","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/S0022-2275(20)38094-9","volume":"23","author":"VI Zannis","year":"1982","unstructured":"Zannis VI, Breslow JL, Utermann G, Mahley RW, Weisgraber KH, Havel RJ, Goldstein JL, Brown MS, Schonfeld G, Hazzard WR, Blum C: Proposed nomenclature of apoE isoproteins, apoE genotypes, and phenotypes. J Lipid Res. 1982, 23: 911-914.","journal-title":"J Lipid Res"},{"key":"497_CR5","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1007\/s000180050223","volume":"54","author":"EH Corder","year":"1998","unstructured":"Corder EH, Lannfelt L, Bogdanovic N, Fratiglioni L, Mori H: The role of APOE polymorphisms in late-onset dementias. Cell Mol Life Sci. 1998, 54: 928-934. 10.1007\/s000180050223.","journal-title":"Cell Mol Life Sci"},{"key":"497_CR6","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1038\/ng0694-180","volume":"7","author":"EH Corder","year":"1994","unstructured":"Corder EH, Saunders AM, Risch NJ, Strittmatter WJ, Schmechel DE, Gaskell PC, Rimmler JB, Locke PA, Conneally PM, Schmader KE: Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease. Nat Genet. 1994, 7: 180-184. 10.1038\/ng0694-180.","journal-title":"Nat Genet"},{"key":"497_CR7","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1001\/jama.1995.03520290025013","volume":"273","author":"EH Corder","year":"1995","unstructured":"Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Roses AD, Pericak-Vance MA, Small GW, Haines JL: The apolipoprotein E E4 allele and sex-specific risk of Alzheimer's disease. JAMA. 1995, 273: 373-374. 10.1001\/jama.1995.03520290025013.","journal-title":"JAMA"},{"key":"497_CR8","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1126\/science.8346443","volume":"261","author":"EH Corder","year":"1993","unstructured":"Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, Roses AD, Haines JL, Pericak-Vance MA: Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science. 1993, 261: 921-923. 10.1126\/science.8346443.","journal-title":"Science"},{"key":"497_CR9","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1212\/WNL.43.8.1467","volume":"43","author":"AM Saunders","year":"1993","unstructured":"Saunders AM, Strittmatter WJ, Schmechel D, George-Hyslop PH, Pericak-Vance MA, Joo SH, Rosi BL, Gusella JF, Crapper-MacLachlan DR, Alberts MJ: Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease. Neurology. 1993, 43: 1467-1472. 10.1212\/WNL.43.8.1467.","journal-title":"Neurology"},{"key":"497_CR10","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1001\/jama.1997.03550160069041","volume":"278","author":"LA Farrer","year":"1997","unstructured":"Farrer LA, Cupples LA, Haines JL, Hyman B, Kukull WA, Mayeux R, Myers RH, Pericak-Vance MA, Risch N, van-Duijn CM: Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. JAMA. 1997, 278: 1349-1356. 10.1001\/jama.1997.03550160069041.","journal-title":"JAMA"},{"key":"497_CR11","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1007\/s004010051080","volume":"98","author":"TG Ohm","year":"1999","unstructured":"Ohm TG, Scharnagl H, Marz W, Bohl J: Apolipoprotein E isoforms and the development of low and high Braak stages of Alzheimer's disease-related lesions. Acta Neuropathol (Berl). 1999, 98: 273-280. 10.1007\/s004010051080.","journal-title":"Acta Neuropathol (Berl)"},{"key":"497_CR12","doi-asserted-by":"publisher","first-page":"9649","DOI":"10.1073\/pnas.90.20.9649","volume":"90","author":"DE Schmechel","year":"1993","unstructured":"Schmechel DE, Saunders AM, Strittmatter WJ, Crain BJ, Hulette CM, Joo SH, Pericak-Vance MA, Goldgaber D, Roses AD: Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease. Proc Natl Acad Sci USA. 1993, 90: 9649-9653. 10.1073\/pnas.90.20.9649.","journal-title":"Proc Natl Acad Sci USA"},{"key":"497_CR13","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1523\/JNEUROSCI.17-02-00516.1997","volume":"17","author":"T Arendt","year":"1997","unstructured":"Arendt T, Schindler C, Bruckner MK, Eschrich K, Bigl V, Zedlick D, Marcova L: Plastic neuronal remodeling is impaired in patients with Alzheimer's disease carrying apolipoprotein epsilon 4 allele. J Neurosci. 1997, 17: 516-529.","journal-title":"J Neurosci"},{"key":"497_CR14","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1111\/j.1749-6632.1998.tb10651.x","volume":"855","author":"AW Bacon","year":"1998","unstructured":"Bacon AW, Bondi MW, Salmon DP, Murphy C: Very early changes in olfactory functioning due to Alzheimer's disease and the role of apolipoprotein E in olfaction. Ann N Y Acad Sci. 1998, 855: 723-731. 10.1111\/j.1749-6632.1998.tb10651.x.","journal-title":"Ann N Y Acad Sci"},{"key":"497_CR15","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.bandc.2004.10.004","volume":"58","author":"R Calhoun-Haney","year":"2005","unstructured":"Calhoun-Haney R, Murphy C: Apolipoprotein epsilon4 is associated with more rapid decline in odor identification than in odor threshold or Dementia Rating Scale scores. Brain Cogn. 2005, 58: 178-182. 10.1016\/j.bandc.2004.10.004.","journal-title":"Brain Cogn"},{"key":"497_CR16","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1080\/13803390490509439","volume":"26","author":"PE Gilbert","year":"2004","unstructured":"Gilbert PE, Murphy C: The effect of the ApoE epsilon4 allele on recognition memory for olfactory and visual stimuli in patients with pathologically confirmed Alzheimer's disease, probable Alzheimer's disease, and healthy elderly controls. J Clin Exp Neuropsychol. 2004, 26: 779-794. 10.1080\/13803390490509439.","journal-title":"J Clin Exp Neuropsychol"},{"key":"497_CR17","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1111\/j.1749-6632.1998.tb10654.x","volume":"855","author":"C Murphy","year":"1998","unstructured":"Murphy C, Bacon AW, Bondi MW, Salmon DP: Apolipoprotein E status is associated with odor identification deficits in nondemented older persons. Ann N Y Acad Sci. 1998, 855: 744-750. 10.1111\/j.1749-6632.1998.tb10654.x.","journal-title":"Ann N Y Acad Sci"},{"key":"497_CR18","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1111\/j.1749-6632.2009.04486.x","volume":"1170","author":"C Murphy","year":"2009","unstructured":"Murphy C, Solomon ES, Haase L, Wang M, Morgan CD: Olfaction in aging and Alzheimer's disease: event-related potentials to a cross-modal odor-recognition memory task discriminate ApoE epsilon4+ and ApoE epsilon 4- individuals. Ann N Y Acad Sci. 2009, 1170: 647-657. 10.1111\/j.1749-6632.2009.04486.x.","journal-title":"Ann N Y Acad Sci"},{"key":"497_CR19","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1016\/j.yhbeh.2008.05.007","volume":"54","author":"EE Sundermann","year":"2008","unstructured":"Sundermann EE, Gilbert PE, Murphy C: The effect of hormone therapy on olfactory sensitivity is dependent on apolipoprotein E genotype. Horm Behav. 2008, 54: 528-533. 10.1016\/j.yhbeh.2008.05.007.","journal-title":"Horm Behav"},{"key":"497_CR20","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1097\/JGP.0b013e318065415f","volume":"15","author":"EE Sundermann","year":"2007","unstructured":"Sundermann EE, Gilbert PE, Murphy C: Apolipoprotein E epsilon4 genotype and gender: effects on memory. Am J Geriatr Psychiatry. 2007, 15: 869-878. 10.1097\/JGP.0b013e318065415f.","journal-title":"Am J Geriatr Psychiatry"},{"key":"497_CR21","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1016\/j.neurobiolaging.2005.08.001","volume":"27","author":"OJ Handley","year":"2006","unstructured":"Handley OJ, Morrison CM, Miles C, Bayer AJ: ApoE gene and familial risk of Alzheimer's disease as predictors of odour identification in older adults. Neurobiol Aging. 2006, 27: 1425-1430. 10.1016\/j.neurobiolaging.2005.08.001.","journal-title":"Neurobiol Aging"},{"key":"497_CR22","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.brainres.2006.12.036","volume":"1137","author":"BP Nathan","year":"2007","unstructured":"Nathan BP, Nannapaneni S, Gairhe S, Nwosu I, Struble RG: The distribution of apolipoprotein E in mouse olfactory epithelium. Brain Res. 2007, 1137: 78-83.","journal-title":"Brain Res"},{"key":"497_CR23","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.brainres.2005.02.011","volume":"1041","author":"BP Nathan","year":"2005","unstructured":"Nathan BP, Nisar R, Short J, Randall S, Grissom E, Griffin G, Switzer PV, Struble RG: Delayed olfactory nerve regeneration in ApoE-deficient mice. Brain Res. 2005, 1041: 87-94. 10.1016\/j.brainres.2005.02.011.","journal-title":"Brain Res"},{"key":"497_CR24","doi-asserted-by":"publisher","first-page":"3065","DOI":"10.1210\/en.2003-1707","volume":"145","author":"BP Nathan","year":"2004","unstructured":"Nathan BP, Barsukova AG, Shen F, McAsey M, Struble RG: Estrogen facilitates neurite extension via apolipoprotein E in cultured adult mouse cortical neurons. Endocrinology. 2004, 145: 3065-3073. 10.1210\/en.2003-1707.","journal-title":"Endocrinology"},{"key":"497_CR25","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/S0006-8993(01)03367-4","volume":"928","author":"BP Nathan","year":"2002","unstructured":"Nathan BP, Jiang Y, Wong GK, Shen F, Brewer GJ, Struble RG: Apolipoprotein E4 inhibits, and apolipoprotein E3 promotes neurite outgrowth in cultured adult mouse cortical neurons through the low- density lipoprotein receptor-related protein. Brain Res. 2002, 928: 96-105. 10.1016\/S0006-8993(01)03367-4.","journal-title":"Brain Res"},{"key":"497_CR26","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1111\/j.1460-9568.2005.04355.x","volume":"22","author":"RD McCurdy","year":"2005","unstructured":"McCurdy RD, Feron F, McGrath JJ, Mackay-Sim A: Regulation of adult olfactory neurogenesis by insulin-like growth factor-I. Eur J Neurosci. 2005, 22: 1581-1588. 10.1111\/j.1460-9568.2005.04355.x.","journal-title":"Eur J Neurosci"},{"key":"497_CR27","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1001\/archotol.124.8.861","volume":"124","author":"F Feron","year":"1998","unstructured":"Feron F, Perry C, McGrath JJ, Mackay-Sim A: New techniques for biopsy and culture of human olfactory epithelial neurons. Arch Otolaryngol Head Neck Surg. 1998, 124: 861-866. 10.1001\/archotol.124.8.861.","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"497_CR28","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1002\/(SICI)1096-9861(19981102)400:4<469::AID-CNE3>3.0.CO;2-8","volume":"400","author":"JM Huard","year":"1998","unstructured":"Huard JM, Youngentob SL, Goldstein BJ, Luskin MB, Schwob JE: Adult olfactory epithelium contains multipotent progenitors that give rise to neurons and non-neural cells. J Comp Neurol. 1998, 400: 469-486. 10.1002\/(SICI)1096-9861(19981102)400:4<469::AID-CNE3>3.0.CO;2-8.","journal-title":"J Comp Neurol"},{"key":"497_CR29","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1002\/cne.10642","volume":"460","author":"W Jang","year":"2003","unstructured":"Jang W, Youngentob SL, Schwob JE: Globose basal cells are required for reconstitution of olfactory epithelium after methyl bromide lesion. J Comp Neurol. 2003, 460: 123-140. 10.1002\/cne.10642.","journal-title":"J Comp Neurol"},{"key":"497_CR30","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1007\/BF01191683","volume":"21","author":"GJ Ramakers","year":"1992","unstructured":"Ramakers GJ, Verhaagen J, Oestreicher AB, Margolis FL, van-Bergen en Henegouwen PM, Gispen WH: Immunolocalization of B-50 (GAP-43) in the mouse olfactory bulb: predominant presence in preterminal axons. J Neurocytol. 1992, 21: 853-869. 10.1007\/BF01191683.","journal-title":"J Neurocytol"},{"key":"497_CR31","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1111\/j.1460-9568.1990.tb00432.x","volume":"2","author":"J Verhaagen","year":"1990","unstructured":"Verhaagen J, Greer CA, Margolis FL: B-50\/GAP43 Gene Expression in the Rat Olfactory System During Postnatal Development and Aging. Eur J Neurosci. 1990, 2: 397-407. 10.1111\/j.1460-9568.1990.tb00432.x.","journal-title":"Eur J Neurosci"},{"key":"497_CR32","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1523\/JNEUROSCI.09-02-00683.1989","volume":"9","author":"J Verhaagen","year":"1989","unstructured":"Verhaagen J, Oestreicher AB, Gispen WH, Margolis FL: The expression of the growth associated protein B50\/GAP43 in the olfactory system of neonatal and adult rats. J Neurosci. 1989, 9: 683-691.","journal-title":"J Neurosci"},{"key":"497_CR33","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1073\/pnas.69.5.1221","volume":"69","author":"FL Margolis","year":"1972","unstructured":"Margolis FL: A brain protein unique to the olfactory bulb. Proc Natl Acad Sci USA. 1972, 69: 1221-1224. 10.1073\/pnas.69.5.1221.","journal-title":"Proc Natl Acad Sci USA"},{"key":"497_CR34","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1111\/j.1471-4159.1975.tb03883.x","volume":"24","author":"A Keller","year":"1975","unstructured":"Keller A, Margolis FL: Immunological studies of the rat olfactory marker protein. J Neurochem. 1975, 24: 1101-1106. 10.1111\/j.1471-4159.1975.tb03883.x.","journal-title":"J Neurochem"},{"key":"497_CR35","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1002\/j.1460-2075.1988.tb03074.x","volume":"7","author":"RD Burgoyne","year":"1988","unstructured":"Burgoyne RD, Cambray-Deakin MA, Lewis SA, Sarkar S, Cowan NJ: Differential distribution of beta-tubulin isotypes in cerebellum. EMBO J. 1988, 7: 2311-2319.","journal-title":"EMBO J"},{"key":"497_CR36","doi-asserted-by":"publisher","first-page":"2011","DOI":"10.1083\/jcb.106.6.2011","volume":"106","author":"W Gu","year":"1988","unstructured":"Gu W, Lewis SA, Cowan NJ: Generation of antisera that discriminate among mammalian alpha-tubulins: introduction of specialized isotypes into cultured cells results in their coassembly without disruption of normal microtubule function. J Cell Biol. 1988, 106: 2011-2022. 10.1083\/jcb.106.6.2011.","journal-title":"J Cell Biol"},{"key":"497_CR37","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1083\/jcb.106.6.2023","volume":"106","author":"SA Lewis","year":"1988","unstructured":"Lewis SA, Cowan NJ: Complex regulation and functional versatility of mammalian alpha- and beta-tubulin isotypes during the differentiation of testis and muscle cells. J Cell Biol. 1988, 106: 2023-2033. 10.1083\/jcb.106.6.2023.","journal-title":"J Cell Biol"},{"key":"497_CR38","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.neulet.2007.03.039","volume":"418","author":"DC Morris","year":"2007","unstructured":"Morris DC, Zhang ZG, Wang Y, Zhang RL, Gregg S, Liu XS, Chopp M: Wnt expression in the adult rat subventricular zone after stroke. Neurosci Lett. 2007, 418: 170-174. 10.1016\/j.neulet.2007.03.039.","journal-title":"Neurosci Lett"},{"key":"497_CR39","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1262\/jrd.18108","volume":"53","author":"S Chiba","year":"2007","unstructured":"Chiba S, Suzuki M, Yamanouchi K, Nishihara M: Involvement of granulin in estrogen-induced neurogenesis in the adult rat hippocampus. J Reprod Dev. 2007, 53: 297-307. 10.1262\/jrd.18108.","journal-title":"J Reprod Dev"},{"key":"497_CR40","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1002\/jnr.21036","volume":"84","author":"T Sasaki","year":"2006","unstructured":"Sasaki T, Kitagawa K, Yagita Y, Sugiura S, Omura-Matsuoka E, Tanaka S, Matsushita K, Okano H, Tsujimoto Y, Hori M: Bcl2 enhances survival of newborn neurons in the normal and ischemic hippocampus. J Neurosci Res. 2006, 84: 1187-1196. 10.1002\/jnr.21036.","journal-title":"J Neurosci Res"},{"key":"497_CR41","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1046\/j.1471-4159.1997.68020587.x","volume":"68","author":"M Narita","year":"1997","unstructured":"Narita M, Bu G, Holtzman DM, Schwartz AL: The low-density lipoprotein receptor-related protein, a multifunctional apolipoprotein E receptor, modulates hippocampal neurite development. J Neurochem. 1997, 68: 587-595.","journal-title":"J Neurochem"},{"key":"497_CR42","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1126\/science.8171342","volume":"264","author":"BP Nathan","year":"1994","unstructured":"Nathan BP, Bellosta S, Sanan DA, Weisgraber KH, Mahley RW, Pitas RE: Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro. Science. 1994, 264: 850-852. 10.1126\/science.8171342.","journal-title":"Science"},{"key":"497_CR43","doi-asserted-by":"publisher","first-page":"27063","DOI":"10.1074\/jbc.270.45.27063","volume":"270","author":"S Bellosta","year":"1995","unstructured":"Bellosta S, Nathan BP, Orth M, Dong LM, Mahley RW, Pitas RE: Stable expression and secretion of apolipoproteins E3 and E4 in mouse neuroblastoma cells produces differential effects on neurite outgrowth. J Biol Chem. 1995, 270: 27063-27071. 10.1074\/jbc.270.45.27063.","journal-title":"J Biol Chem"},{"key":"497_CR44","doi-asserted-by":"publisher","first-page":"19791","DOI":"10.1074\/jbc.270.34.19791","volume":"270","author":"BP Nathan","year":"1995","unstructured":"Nathan BP, Chang KC, Bellosta S, Brisch E, Ge N, Mahley RW, Pitas RE: The inhibitory effect of apolipoprotein E4 on neurite outgrowth is associated with microtubule depolymerization. J Biol Chem. 1995, 270: 19791-19799. 10.1074\/jbc.270.34.19791.","journal-title":"J Biol Chem"},{"key":"497_CR45","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1172\/JCI200113992","volume":"108","author":"J Herz","year":"2001","unstructured":"Herz J, Strickland DK: LRP: a multifunctional scavenger and signaling receptor. J Clin Invest. 2001, 108: 779-784.","journal-title":"J Clin Invest"},{"key":"497_CR46","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/S0006-8993(96)01321-2","volume":"747","author":"MD Brown","year":"1997","unstructured":"Brown MD, Banker GA, Hussaini IM, Gonias SL, VandenBerg SR: Low density lipoprotein receptor-related protein is expressed early and becomes restricted to a somatodendritic domain during neuronal differentiation in culture. Brain Res. 1997, 747: 313-317. 10.1016\/S0006-8993(96)01321-2.","journal-title":"Brain Res"},{"key":"497_CR47","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1111\/j.1749-6632.1994.tb44298.x","volume":"737","author":"J Herz","year":"1994","unstructured":"Herz J, Willnow TE: Functions of the LDL receptor gene family. Ann N Y Acad Sci. 1994, 737: 14-19. 10.1111\/j.1749-6632.1994.tb44298.x.","journal-title":"Ann N Y Acad Sci"},{"key":"497_CR48","first-page":"343","volume":"8","author":"MZ Kounnas","year":"1994","unstructured":"Kounnas MZ, Haudenschild CC, Strickland DK, Argraves WS: Immunological localization of glycoprotein 330, low density lipoprotein receptor related protein and 39 kDa receptor associated protein in embryonic mouse tissues. In Vivo. 1994, 8: 343-351.","journal-title":"In Vivo"},{"key":"497_CR49","doi-asserted-by":"crossref","first-page":"9035","DOI":"10.1016\/S0021-9258(19)50384-2","volume":"267","author":"SE Williams","year":"1992","unstructured":"Williams SE, Ashcom JD, Argraves WS, Strickland DK: A novel mechanism for controlling the activity of alpha 2-macroglobulin receptor\/low density lipoprotein receptor-related protein. Multiple regulatory sites for 39-kDa receptor-associated protein. J Biol Chem. 1992, 267: 9035-9040.","journal-title":"J Biol Chem"},{"key":"497_CR50","doi-asserted-by":"crossref","first-page":"26172","DOI":"10.1016\/S0021-9258(18)35732-6","volume":"267","author":"TE Willnow","year":"1992","unstructured":"Willnow TE, Goldstein JL, Orth K, Brown MS, Herz J: Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance. J Biol Chem. 1992, 267: 26172-26180.","journal-title":"J Biol Chem"},{"key":"497_CR51","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1111\/j.1749-6632.1996.tb34412.x","volume":"777","author":"RW Mahley","year":"1996","unstructured":"Mahley RW, Nathan BP, Pitas RE: Apolipoprotein E. Structure, function, and possible roles in Alzheimer's disease. Ann N Y Acad Sci. 1996, 777: 139-145. 10.1111\/j.1749-6632.1996.tb34412.x.","journal-title":"Ann N Y Acad Sci"},{"key":"497_CR52","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1097\/00041433-199504000-00005","volume":"6","author":"RW Mahley","year":"1995","unstructured":"Mahley RW, Nathan BP, Bellosta S, Pitas RE: Apolipoprotein E: impact of cytoskeletal stability in neurons and the relationship to Alzheimer's disease. Curr Opin Lipidol. 1995, 6: 86-91. 10.1097\/00041433-199504000-00005.","journal-title":"Curr Opin Lipidol"},{"key":"497_CR53","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1111\/j.1532-5415.1998.tb01532.x","volume":"46","author":"R O'Hara","year":"1998","unstructured":"O'Hara R, Yesavage JA, Kraemer HC, Mauricio M, Friedman LF, Murphy GM: The APOE epsilon4 allele is associated with decline on delayed recall performance in community-dwelling older adults. J Am Geriatr Soc. 1998, 46: 1493-1498.","journal-title":"J Am Geriatr Soc"}],"container-title":["Journal of Biomedical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1423-0127-20-49.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T00:36:44Z","timestamp":1630543004000},"score":1,"resource":{"primary":{"URL":"https:\/\/jbiomedsci.biomedcentral.com\/articles\/10.1186\/1423-0127-20-49"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,12]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["497"],"URL":"https:\/\/doi.org\/10.1186\/1423-0127-20-49","relation":{},"ISSN":["1423-0127"],"issn-type":[{"value":"1423-0127","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,12]]},"assertion":[{"value":"10 May 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 July 2013","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 July 2013","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"49"}}